The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Multiple Organ Failure Pathophysiology and Potential Future Therapy
Open accessAbstract
Multiple organ failure (MOF) has reached epidemic proportions in most intensive care units and is fast becoming the most common cause of death in the surgical intensive care unit. Furthermore, in spite of the development of successive generations of new and more powerful antibiotics and increasing sophisticated techniques of organ support, our ability to salvage patients once MOF has become established has not appreciably improved over the last two decades. Clearly, new therapeutic strategies aimed at preventing or limiting the development of the physiologic abnormalities that induce organ failure are needed to improve survival in these critically ill patients. Based on our rapidly increasing knowledge of the mechanisms of MOF and the fruits of molecular biology, a number of new therapeutic approaches are in various stages of development. To effectively use these new therapeutic options as they become available, it is necessary to have a clear understanding of the pathophysiology of MOF. Thus, the goals of this review are to integrate the vast amount of new information on the basic biology of MOF and to focus special attention on the potential therapeutic consequences of these recent advances in our understanding of this complex and perplexing syndrome.
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Cites
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Cited by
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients
Ferreira, F. L. (2001) · JAMA · doi:10.1001/jama.286.14.1754 · Cited by 2,862
Lactoferrin as a natural immune modulator
Actor, J., Hwang, S.-A., & Kruzel, M. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788453202 · Cited by 455
Multiple organ dysfunction syndrome: exploring the paradigm of complex nonlinear systems
Seely, A. J. E., & Christou, N. V. (2000) · Critical Care Medicine · doi:10.1097/00003246-200007000-00003 · Cited by 287
Rupani, B., Caputo, F. J., Watkins, A. C., Vega, D., Magnotti, L. J., Lu, Q., Xu, D. Z., & Deitch, E. A. (2007) · Surgery · doi:10.1016/j.surg.2006.10.008 · Cited by 102
Self-citation
Metadata
- Authors
- DEITCH, E. A.
- Venue
- Annals of Surgery
- Published
- 1992-08
- Volume
- 216
- Issue
- 2
- Pages
- 117-134
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2002008524
- Cited by
- 1,380
- References
- 5
- FWCI
- 34.58
- Type
- journal article
- Language
- en
- Open access
- green
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