The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Multiple Organ Failure Pathophysiology and Potential Future Therapy
Open accessAbstract
Multiple organ failure (MOF) has reached epidemic proportions in most intensive care units and is fast becoming the most common cause of death in the surgical intensive care unit. Furthermore, in spite of the development of successive generations of new and more powerful antibiotics and increasing sophisticated techniques of organ support, our ability to salvage patients once MOF has become established has not appreciably improved over the last two decades. Clearly, new therapeutic strategies aimed at preventing or limiting the development of the physiologic abnormalities that induce organ failure are needed to improve survival in these critically ill patients. Based on our rapidly increasing knowledge of the mechanisms of MOF and the fruits of molecular biology, a number of new therapeutic approaches are in various stages of development. To effectively use these new therapeutic options as they become available, it is necessary to have a clear understanding of the pathophysiology of MOF. Thus, the goals of this review are to integrate the vast amount of new information on the basic biology of MOF and to focus special attention on the potential therapeutic consequences of these recent advances in our understanding of this complex and perplexing syndrome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677
Gut Bacterial Translocation via the Portal Vein: A Clinical Perspective with Major Torso Trauma
MOORE, F. A., MOORE, E. E., POGGETTI, R., McANENA, O. J., PETERSON, V. M., ABERNATHY, C. M., & PARSONS, P. E. (1991) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199105000-00006 · Cited by 491
Cited by
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients
Ferreira, F. L. (2001) · JAMA · doi:10.1001/jama.286.14.1754 · Cited by 2,862
Lactoferrin as a natural immune modulator
Actor, J., Hwang, S.-A., & Kruzel, M. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788453202 · Cited by 455
Multiple organ dysfunction syndrome: exploring the paradigm of complex nonlinear systems
Seely, A. J. E., & Christou, N. V. (2000) · Critical Care Medicine · doi:10.1097/00003246-200007000-00003 · Cited by 287
Rupani, B., Caputo, F. J., Watkins, A. C., Vega, D., Magnotti, L. J., Lu, Q., Xu, D. Z., & Deitch, E. A. (2007) · Surgery · doi:10.1016/j.surg.2006.10.008 · Cited by 102
Self-citationTrauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice
Reino, D. C., Pisarenko, V., Palange, D., Doucet, D., Bonitz, R. P., Lu, Q., Colorado, I., Sheth, S. U., Chandler, B., Kannan, K. B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014829 · Cited by 97
Self-citationDiagnosis biomarkers in acute intestinal ischemic injury: so close, yet so far
Peoc’h, K., Nuzzo, A., Guedj, K., Paugam, C., & Corcos, O. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0291 · Cited by 86
Partrick, D. A., Moore, E. E., Fullerton, D. A., Barnett, C. C., Meldrum, D. R., & Silliman, C. C. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1999.5702 · Cited by 82
The immunological consequences of injury
Ni Choileain, N., & Redmond, H. P. (2006) · The Surgeon · doi:10.1016/s1479-666x(06)80018-1 · Cited by 73
Intestinal permeability is decreased in anorexia nervosa
Monteleone, P., Carratù, R., Cartenì, M., Generoso, M., Lamberti, M., Magistris, L. D., Brambilla, F., Colurcio, B., Secondulfo, M., & Maj, M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001374 · Cited by 64
Deitch, E. A., Xu, D.-Z., & Lu, Q. (2006) · Journal of Organ Dysfunction · doi:10.1080/17471060600551772 · Cited by 35
Lu, Q., Xu, D.-Z., Sharpe, S., Doucet, D., Pisarenko, V., Lee, M., & Deitch, E. A. (2011) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e3181e1221b · Cited by 26
Self-citation
Metadata
- Authors
- DEITCH, E. A.
- Venue
- Annals of Surgery
- Published
- 1992-08
- Volume
- 216
- Issue
- 2
- Pages
- 117-134
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2002008524
- Cited by
- 1,380
- References
- 5
- FWCI
- 34.58
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
