Cited by 1,099Wound Healing and TreatmentsBacterial biofilms and quorum sensingSurgical site infection prevention

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Bacteria and wound healing

Edwards, Ruth, Harding, Keith G·2004·Current Opinion in Infectious Diseases

DOI 10.1097/00001432-200404000-00004

Open this paper in CoChat — free account

Abstract

PURPOSE OF REVIEW: Wound healing is a complex process with many potential factors that can delay healing. There is increasing interest in the effects of bacteria on the processes of wound healing. All chronic wounds are colonized by bacteria, with low levels of bacteria being beneficial to the wound healing process. Wound infection is detrimental to wound healing, but the diagnosis and management of wound infection is controversial, and varies between clinicians. RECENT FINDINGS: There is increasing recognition of the concept of critical colonization or local infection, when wound healing may be delayed in the absence of the typical clinical features of infection. The progression from wound colonization to infection depends not only on the bacterial count or the species present, but also on the host immune response, the number of different species present, the virulence of the organisms and synergistic interactions between the different species. There is increasing evidence that bacteria within chronic wounds live within biofilm communities, in which the bacteria are protected from host defences and develop resistance to antibiotic treatment. SUMMARY: An appreciation of the factors affecting the progression from colonization to infection can help clinicians with the interpretation of clinical findings and microbiological investigations in patients with chronic wounds. An understanding of the physiology and interactions within multi-species biofilms may aid the development of more effective methods of treating infected and poorly healing wounds. The emergence of consensus guidelines has helped to optimize clinical management.

Integrity signals

Registry

Crossref · 10.1097/00001432-200404000-00004

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators
Fuqua, W. C., Winans, S. C., & Greenberg, E. P. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.2.269-275.1994 · Cited by 2,941
The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms
Ceri, H., Olson, M. E., Stremick, C., Read, R. R., Morck, D., & Buret, A. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.6.1771-1776.1999 · Cited by 2,155
Wound Microbiology and Associated Approaches to Wound Management
Bowler, P. G., Duerden, B. I., & Armstrong, D. G. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.2.244-269.2001 · Cited by 1,634
Wound bed preparation: a systematic approach to wound management
Schultz, G. S., Sibbald, R. G., Falanga, V., Ayello, E. A., Dowsett, C., Harding, K. G., Romanelli, M., Stacey, M. C., Téot, L., & Vanscheidt, W. (2003) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.11.s2.1.x · Cited by 1,440
Self-citation
A component of innate immunity prevents bacterial biofilm development
Singh, P. K., Parsek, M. R., Greenberg, E. P., & Welsh, M. J. (2002) · Nature · doi:10.1038/417552a · Cited by 1,026
Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomised controlled trial
Melling, A. C., Ali, B., Scott, E. M., & Leaper, D. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06071-8 · Cited by 712
WOUND INFECTION
Robson, M. C. (1997) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70572-7 · Cited by 643
The validity of the clinical signs and symptoms used to identify localized chronic wound infection
Gardner, S. E., Frantz, R. A., & Doebbeling, B. N. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00178.x · Cited by 415
Biochemical analysis of acute and chronic wound environments
Tarnuzzer, R. W., & Schultz, G. S. (1996) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1996.40307.x · Cited by 372

Show all 43 references

Research works printed but not linked: 9

Dow, 1999, Ostomy/Wound Manage, 45, 23
Krizek, 1967, Surg Forum, 18, 518
Bowler, 2003, Ostomy/Wound Manage, 49, 44
Wall, 2003, Wound Repair Regen, 20, 346
DeBeer, 1994, ioeng, 44, 636
Mertz, 2003, Wounds, 15, 129
Serralta, 2001, Wounds, 13, 29
Harrison-Balestra, 2003, Dermatol Surg, 29, 631
Geronemus, 1975, Arch Dermatol, 111, 1311

Sorted by citations

Items 401–500 of 1,000

The effect of clary sage oil on staphylococci responsible for wound infections
Sienkiewicz, M., Głowacka, A., Poznańska-Kurowska, K., Kaszuba, A., Urbaniak, A., & Kowalczyk, E. (2015) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2014.40957 · Cited by 31
In vitro activity of a polyhexanide–betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens
López-Rojas, R., Fernández-Cuenca, F., Serrano, L., & Pascual, Á. (2016) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2016.02.008 · Cited by 31
Periprosthetic Joint Infection of the Hip and Knee
Springer, B. D., & Parvizi, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7928-4 · Cited by 30
Staphylococcus aureus impairs cutaneous wound healing by activating the expression of a gap junction protein, connexin-43 in keratinocytes
Xu, W., Dielubanza, E. J., Maisel-Campbell, A. L., Leung, K. P., Mustoe, T. A., Hong, S. J., & Galiano, R. D. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03545-4 · Cited by 31
Understanding the host inflammatory response to wound infection: An in vivo study of K lebsiella pneumoniae in a rabbit ear wound model
Seth, A. K., Geringer, M. R., Gurjala, A. N., Abercrombie, J. J., Chen, P., You, T., Hong, S. J., Galiano, R. D., Mustoe, T. A., & Leung, K. P. (2012) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2012.00764.x · Cited by 31
Topical application of the lectin A rtin M accelerates wound healing in rat oral mucosa by enhancing TGF ‐β and VEGF production
Kim, Y. J., Carvalho, F. C., de Souza, J. A. C., Gonçalves, P. C. G., Nogueira, A. V. B., Spolidório, L. C., Roque‐Barreira, M. C., & Cirelli, J. A. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12041 · Cited by 35
Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration
Rai, R., Roether, J. A., Knowles, J. C., Mordan, N. J., Salih, V. M., Locke, I. C., Gordge, M. P., McCormick, A. N., Mohn, D., Stark, W. J., et al. (2016) · International Journal of Polymeric Materials · doi:10.1080/00914037.2016.1217530 · Cited by 31
A Randomized, Placebo-controlled, Double-blind Clinical Trial of Bacteriophage Cocktails in Chronic Wound Infections
Karn, S. L., Bhartiya, S. K., Pratap, A., Saroj, S. K., Kumar, R., Sahu, M., Gangwar, M., & Nath, G. (2024) · The International Journal of Lower Extremity Wounds · doi:10.1177/15347346231226342 · Cited by 34
Clinical management of non-healing wounds
Chamanga, E. T. (2018) · Nursing Standard · doi:10.7748/ns.2018.e10829 · Cited by 30
Silica-Based Nanosystems for Therapeutic Applications in the Skin
Arriagada, F., Nonell, S., & Morales, J. O. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0052 · Cited by 31
Rapid enzyme analysis as a diagnostic tool for wound infection: Comparison between clinical judgment, microbiological analysis, and enzyme analysis
Blokhuis‐Arkes, M. H. E., Haalboom, M., van der Palen, J. A. M., Heinzle, A., Sigl, E., Guebitz, G. M., & Beuk, R. J. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12282 · Cited by 30
A Paradigm of Fibroblast Activation and Dermal Wound Contraction to Guide the Development of Therapies for Chronic Wounds and Pathologic Scars
Levinson, H. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0389 · Cited by 30
Wound outcome in combat injuries is associated with a unique set of protein biomarkers
Chromy, B. A., Eldridge, A., Forsberg, J. A., Brown, T. S., Kirkup, B. C., Jaing, C. J., Be, N. A., Elster, E. A., & Luciw, P. A. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-281 · Cited by 30
Treatment of Infected Soft Tissue Blast Injury in Swine by Regulated Negative Pressure Wound Therapy
Li, J., Topaz, M., Tan, H., Li, Y., Li, W., Xun, W., Yuan, Y., Chen, S., & Li, X. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e318269d1ca · Cited by 30
Volatile organic compound detection as a potential means of diagnosing cutaneous wound infections
Ashrafi, M. H., Bates, M., Baguneid, M. S., Alonso-Rasgado, T. A., Rautemaa‐Richardson, R., & Bayat, A. (2017) · Wound Repair and Regeneration · doi:10.1111/wrr.12563 · Cited by 30
Evaluation of wound healing effect of herbal lotion in albino rats and its antibacterial activities
Dons, T., & Soosairaj, S. (2018) · Clinical Phytoscience · doi:10.1186/s40816-018-0065-z · Cited by 30
Buruli Ulcer
Röltgen, K., & Pluschke, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-11114-4 · Cited by 32
Accelerated wound healing process in rat by probiotic Lactobacillus reuteri derived ointment
Khodaii, Z., Afrasiabi, S., Hashemi, S. A., Ardeshirylajimi, A., & Natanzi, M. M. (2019) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2018-0150 · Cited by 29
Gum acacia-PVA hydrogel blends for wound healing
Parwani, L., Bhatnagar, M., Bhatnagar, A., Sharma, V., & Sharma, V. (2019) · Vegetos · doi:10.1007/s42535-019-00009-4 · Cited by 29
Application of 3D printing & 3D bioprinting for promoting cutaneous wound regeneration
Sun, Y., Bombin, A. D. J., Boyd, P., Dunne, N., & McCarthy, H. O. (2022) · Bioprinting · doi:10.1016/j.bprint.2022.e00230 · Cited by 29
Chitosan/poly (3-hydroxy butyric acid-co-3-hydroxy valeric acid) electrospun nanofibers with cephradine for superficial incisional skin wound infection management
Song, J., Razzaq, A., Khan, N. U., Iqbal, H., & Ni, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126229 · Cited by 29
MgO@polydopamine Nanoparticle-Loaded Photothermal Microneedle Patches Combined with Chitosan Gel Dressings for the Treatment of Infectious Wounds
Zheng, G., Xie, J., Yao, Y., Shen, S., Weng, J., Yang, Q., & Yan, Q. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c16880 · Cited by 29
Integrins regulation of wound healing processes: insights for chronic skin wound therapeutics
Dong, Y., Lu, Z., Nie, F., & Chong, Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1324441 · Cited by 34
In Vitro and In Vivo Evaluation of Electrospun PVA Nanofiber Containing ZnO/Curcumin for Wound Healing Application
Nemati, M. M., Heidari, R., Keshavarzi, A., Ahmadi, A., Abedi, M., Ranjbar, S., & Ghasemi, Y. (2024) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-024-05018-x · Cited by 28
Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta‐analysis of comparative clinical trials
Woo, K. Y., Dowsett, C., Costa, B., Ebohon, S., Woodmansey, E. J., & Malone, M. (2021) · International Wound Journal · doi:10.1111/iwj.13560 · Cited by 28
Staphylococcus aureus impairs dermal fibroblast functions with deleterious effects on wound healing
Yokota, M., Häffner, N., Kassier, M., Brunner, M., Shambat, S. M., Brennecke, F., Gote-Schniering, J., Maggio, E. M., Distler, O., Zinkernagel, A. S., et al. (2021) · The FASEB Journal · doi:10.1096/fj.201902836r · Cited by 29
Light-Stimulated Carbon Dot Hydrogel: Targeting and Clearing Infectious Bacteria In Vivo
Lee, C. H., Song, S. Y., Chung, Y. J., Choi, E. K., Jang, J., Lee, D., Kim, H. D., Kim, D.-U., & Park, C. B. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c01157 · Cited by 28
Synthesis, characterization, and light‐controlled antibiotic application of a composite material derived from polyurethane and silica xerogel with embedded photoactive manganese nitrosyl
Heilman, B. J., Halpenny, G. M., & Mascharak, P. K. (2011) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31904 · Cited by 28
Reduced cytotoxicity of polyhexamethylene biguanide hydrochloride (PHMB) by egg phosphatidylcholine while maintaining antimicrobial efficacy
Müller, G., Krämer, A., Schmitt, J., Harden, D., & Koburger, T. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.02.024 · Cited by 28
Antimicrobial activity of a chlorhexidine intravascular catheter site gel dressing
Karpanen, T. J., Casey, A. L., Conway, B. R., Lambert, P. A., & Elliott, T. S. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr191 · Cited by 28
AgNPs loaded adenine-modified chitosan composite POSS-PEG hybrid hydrogel with enhanced antibacterial and cell proliferation properties for promotion of infected wound healing
Zhou, C., Jiang, T., Liu, S., He, Y., Yang, G., Nie, J., Wang, F., Yang, X., Chen, Z., & Lu, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131575 · Cited by 27
Antibacterial activity of medicinal plants and their role in wound healing
Breijyeh, Z., & Karaman, R. (2024) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-024-00634-0 · Cited by 39
In Situ Formation of Hydrogels Loaded with ZnO Nanoparticles Promotes Healing of Diabetic Wounds in Rats
Wang, J., Zhang, C.-N., Xu, X., Sun, T., Kong, L.-C., & Ning, R. (2024) · ACS Omega · doi:10.1021/acsomega.4c08537 · Cited by 27
Nitric oxide releasing two-part creams containing S-nitrosoglutathione and zinc oxide for potential topical antimicrobial applications
Doverspike, J. C., Zhou, Y., Wu, J., Tan, X., Xi, C., & Meyerhoff, M. E. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.05.009 · Cited by 28
Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay
Brunauer, A., Verboket, R. D., Kainz, D. M., von Stetten, F., & Früh, S. M. (2021) · Biosensors · doi:10.3390/bios11030074 · Cited by 27
A novel wound dressing based on a gold nanoparticle self-assembled hydrogel to promote wound healing
Chen, W., Chu, R., Li, H., Hua, T., Chen, H., Li, R., Zhou, D., Cao, S., Ye, S., & Li, H. (2023) · Materials Advances · doi:10.1039/d3ma00130j · Cited by 29
Clinical efficacy of a silver‐releasing foam dressing in venous leg ulcer healing: a randomised controlled trial
Senet, P., Bause, R., Jørgensen, B., & Fogh, K. (2013) · International Wound Journal · doi:10.1111/iwj.12022 · Cited by 27
The Correlation Between Time to Skin Grafting and Hypertrophic Scarring Following an Acute Contact Burn in a Porcine Model
Chan, Q. E., Harvey, J. G., Graf, N. S., Godfrey, C., & Holland, A. J. A. (2011) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31823356ce · Cited by 27
Anti-pseudomonal and anti-endotoxic effects of surfactin-stabilized biogenic silver nanocubes ameliorated wound repair in streptozotocin-induced diabetic mice
Krishnan, N., Velramar, B., Pandiyan, R., & Velu, R. K. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1324461 · Cited by 27
Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing – A feasibility study
Kalan, L., Zhou, M., Labbie, M., & Willing, B. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187728 · Cited by 26
Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model
Guoqi, W., Li, Z., Wang, S., Tongtong, L., Lihai, Z., Zhang, L., & Peifu, T. (2018) · Antonie van Leeuwenhoek · doi:10.1007/s10482-018-1045-5 · Cited by 26
The Bacterial Metabolite Indole Inhibits Regeneration of the Planarian Flatworm Dugesia japonica
Lee, F. J., Williams, K. B., Levin, M. G., & Wolfe, B. E. (2018) · iScience · doi:10.1016/j.isci.2018.11.021 · Cited by 26
Dual effective core-shell electrospun scaffolds: Promoting osteoblast maturation and reducing bacteria activity
de Paula, M. M. M., Afewerki, S., Viana, B. C., Webster, T. J., Lobo, A. O., & Marciano, F. R. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109778 · Cited by 26
Effectiveness of a single treatment of photodynamic therapy using topical administration of 5-aminolevulinic acid on methicillin-resistant Staphylococcus aureus-infected wounds of diabetic mice
Huang, J., Guo, M., Wu, M., Shen, S., Shi, L., Cao, Z. W., Wang, X., & Wang, H. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101748 · Cited by 26
The Ambivalent Role of Skin Microbiota and Adrenaline in Wound Healing and the Interplay between Them
Luqman, A., & Götz, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094996 · Cited by 30
Willow Bark-Derived Material with Antibacterial and Antibiofilm Properties for Potential Wound Dressing Applications
Dou, J., Ilina, P., Cruz, C. D., Nurmi, D., Vidarte, P. Z., Rissanen, M., Tammela, P., & Vuorinen, T. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00849 · Cited by 26
Bioactive doped metals: high synergism in the bactericidal activity of chlorhexidine@silver towards wound pathogenic bacteria
Ben‐Knaz, R., Pedahzur, R., & Avnir, D. (2013) · RSC Advances · doi:10.1039/c3ra41196f · Cited by 26
The Role of a Silver Releasing Lipido-colloid Contact Layer in Venous Leg Ulcers Presenting Inflammatory Signs Suggesting Heavy Bacterial Colonization: Results of a Randomized Controlled Study.
Lazareth, I., Meaume, S., Sigal-Grinberg, M., Combemale, P., Guyadec, T. L., Zagnoli, A., Perrot, J., Sauvadet, A., & Bohbot, S. (2008) · PubMed · Cited by 26
Toxicity of silver nanoparticles released by Hancornia speciosa (Mangabeira) biomembrane
Almeida, L. M., Magno, L. N., Canedo, A., Guidelli, É. J., Filho, O. B., Kinoshita, Â., & Gonçalves, P. J. (2018) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2018.11.050 · Cited by 26
A Double-Edged Sword: The Role of VEGF in Wound Repair and Chemoattraction of Opportunist Pathogens
Birkenhauer, E., & Neethirajan, S. R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047159 · Cited by 25
Chemical composition of Moringa oleifera ethyl acetate fraction and its biological activity in diabetic human dermal fibroblasts
Arulselvan, P., Gothai, S., Muniandy, K., Zarin, M., Sean, T., Kumar, S., Munusamy, M., & Fakurazi, S. (2017) · Pharmacognosy Magazine · doi:10.4103/pm.pm_368_16 · Cited by 25
Charge-Mediated Co-assembly of Amphiphilic Peptide and Antibiotics Into Supramolecular Hydrogel With Antibacterial Activity
Xu, L., Shen, Q., Huang, L., Xu, X., & He, H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.629452 · Cited by 25
Fig latex inhibits the growth of pathogenic bacteria invading human diabetic wounds and accelerates wound closure in diabetic mice
Salah, M. J., Badr, G., Hetta, ‏. F., Khalifa, W. A. M., & Shoreit, A. A. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-26338-0 · Cited by 25
Critical colonisation of chronic wounds: microbial mechanisms
White, R. J., & CUTTING, K. F. (2008) · Bucks New University Repository (Bucks New University) · Cited by 25
9. The Antimicrobial Activity of Medicinal Maggots
Nigam, Y., & Wilson, M. R. (2022) · Open Book Publishers · doi:10.11647/obp.0300.09 · Cited by 23
14. Medicinal Maggot Production
Stadler, F., & Takáč, P. (2022) · Open Book Publishers · doi:10.11647/obp.0300.14 · Cited by 23
Wound healing potential of human umbilical cord mesenchymal stem cell conditioned medium: An in vitro and in vivo study in diabetes-induced rats
Hendrawan, S., Kusnadi, Y., Lagonda, C. A., Fauza, D., Lheman, J., Budi, E., Manurung, B. S., Baer, H. U., & Tan, S. T. (2021) · Veterinary World · doi:10.14202/vetworld.2021.2109-2117 · Cited by 29
An antibacterial and anti-oxidant hydrogel containing hyperbranched poly-l-lysine and tea polyphenols accelerates healing of infected wound
Wang, J., Sun, Y., Liu, X., Kang, Y., Cao, W., Ye, J., & Gao, C. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213755 · Cited by 24
Beneficial and deleterious bacterial–host interactions in chronic wound pathophysiology
Rumbaugh, K. P., Watters, C., & Yuan, T. (2015) · Chronic Wound Care Management and Research · doi:10.2147/cwcmr.s60317 · Cited by 25
Anaerobes in Biofilm-Based Healthcare-Associated Infections
Vuotto, C., & Donelli, G. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-11038-7_6 · Cited by 24
Effcacy of a silver lipidocolloid dressing on heavily colonised wounds: a republished RCT
Lazareth, I., Meaume, S., Sigal-Grinberg, M., Combemale, P., Guyadec, T. L., Zagnoli, A., Perrot, J., Sauvadet, A., & Bohbot, S. (2012) · Journal of Wound Care · doi:10.12968/jowc.2012.21.2.96 · Cited by 24
Efficacy of topical pale sulfonated shale oil in the treatment of venous leg ulcers: A randomized, controlled, multicenter study
Beckert, S., Warnecke, J., Zelenková, H., Kovnerystyy, O., Stege, H., Cholcha, W., Königsrainer, A., & Coerper, S. (2006) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.09.028 · Cited by 24
5. Medicinal Maggot Application and Maggot Therapy Dressing Technology
Sherman, R. A. (2022) · Open Book Publishers · doi:10.11647/obp.0300.05 · Cited by 22
Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine)
Knopf‐Marques, H., Barthès, J., Lachaal, S., Mutschler, A., Muller, C. B., Dufour, F., Rabineau, M., Courtial, E., Bystroňová, J., Marquette, C. A., et al. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109898 · Cited by 23
Real-time detection of volatile metabolites enabling species-level discrimination of bacterial biofilms associated with wound infection
Slade, E. A., Thorn, R. M. S., Young, A. E., & Reynolds, D. M. (2021) · Journal of Applied Microbiology · doi:10.1111/jam.15313 · Cited by 23
In vitro antistaphylococcal effects of a novel 45S5 bioglass/agar- gelatin biocomposite films
Rivadeneira, J., Audisio, M. C., Boccaccini, A. R., & Gorustovich, A. A. (2013) · Journal of Applied Microbiology · doi:10.1111/jam.12254 · Cited by 23
Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?
Ryck, T. D., Vanlancker, E., Grootaert, C., Roman, B. I., Coen, L. M. D., Vandenberghe, I. H. M., Stevens, C. V., Bracke, M., de Wiele, T. V., & Vanhoecke, B. W. A. (2015) · AMB Express · doi:10.1186/s13568-015-0116-5 · Cited by 23
Enhancing effect of γ-cyclodextrin on wound dressing properties of sacran hydrogel film
Wathoni, N., Motoyama, K., Higashi, T., Okajima, M. K., Kaneko, T., & Arima, H. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.09.093 · Cited by 23
Cold atmospheric plasma (CAP) differently affects migration and differentiation of keratinocytes via hydrogen peroxide and nitric oxide-related products
Balzer, J., Demir, E., Kogelheide, F., Fuchs, P. C., Stapelmann, K., & Opländer, C. (2018) · Clinical Plasma Medicine · doi:10.1016/j.cpme.2018.11.001 · Cited by 25
A review on wound healing
Karunagaran, M., & Visha, M. (2019) · International Journal of Clinicopathological Correlation · doi:10.4103/ijcpc.ijcpc_13_19 · Cited by 23
Phytochemical and Antibacterial Evaluations of the Stem Bark of Newbouldia laevis against Isolates from Infected Wounds and Eyes
Akerele, J., Ayinde, B., & Ngiagah, J. (2011) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v10i2.66566 · Cited by 23
PHMB and its potential contribution to wound management
Gray, D., Barrett, S., Battacharyya, M., Butcher, M., Enoch, S., Fumerola, S., Stephen‐Haynes, J., Edwards-Jones, V., Leaper, D. J., Strohal, R., et al. (2010) · Cited by 23
The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice
Borkow, G., & Melamed, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030562 · Cited by 24
4. Indications, Contraindications, Interactions, and Side-effects of Maggot Therapy
Sherman, R. A. (2022) · Open Book Publishers · doi:10.11647/obp.0300.04 · Cited by 22
3. Wound Aetiologies, Patient Characteristics, and Healthcare Settings Amenable to Maggot Therapy
Sherman, R. A., & Stadler, F. (2022) · Open Book Publishers · doi:10.11647/obp.0300.03 · Cited by 21
Fabrication of antimicrobial cationic hydrogels driven by physically and chemically crosslinking for wound healing
Wang, Z., Cheng, Q., Lu, B., Zhang, P., Zhang, L., Wu, W., Li, J., & Narain, R. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129213 · Cited by 22
Flaminal® versus Flamazine® in the treatment of partial thickness burns: A randomized controlled trial on clinical effectiveness and scar quality (FLAM study)
Rashaan, Z. M., Krijnen, P., Kwa, K. A. A., van der Vlies, C. H., Schipper, I. B., & Breederveld, R. S. (2019) · Wound Repair and Regeneration · doi:10.1111/wrr.12699 · Cited by 22
Er:YAG laser vs. sharp debridement in management of chronic wounds: Effects on pain and bacterial load
Hajhosseini, B., Chiou, G. J., Dori, G., Fukaya, E., Chandra, V., Meyer, S., & Gurtner, G. C. (2019) · Wound Repair and Regeneration · doi:10.1111/wrr.12764 · Cited by 22
Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions
Zhang, W., Xia, S.-Z., Weng, T.-T., Yang, M., Shao, J., Zhang, M., Wang, J.-L., Xu, P., Wei, J.-T., Jin, R.-H., et al. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100395 · Cited by 22
3D-printed wound dressing platform for protein administration based on alginate and zinc oxide tetrapods
Schadte, P., Rademacher, F., Andresen, G., Hellfritzsch, M., Qiu, H., Maschkowitz, G., Gläser, R., Heinemann, N., Drücke, D., Fickenscher, H., et al. (2023) · Nano Convergence · doi:10.1186/s40580-023-00401-6 · Cited by 24
Risk Factors for Non-Healing Wounds—A Single-Centre Study
Wolny, D., Štěpánek, L., Horáková, D., Thomas, J., Zapletalová, J., & Patel, M. S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041003 · Cited by 22
Light-based therapy on wound healing : a review
Suan, L. P., Bidin, N., Chong, J. C., & Hamid, A. (2014) · Laser Physics · doi:10.1088/1054-660x/24/8/083001 · Cited by 22
Epithelial Overexpression of SOCS-3 in Transgenic Mice Exacerbates Wound Inflammation in the Presence of Elevated TGF-β1
Linke, A., Goren, I., Bösl, M. R., Pfeilschifter, J. M., & Frank, S. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.345 · Cited by 22
Properties of honey: its mode of action and clinical outcomes
Stephen‐Haynes, J., & Callaghan, R. (2011) · Cited by 22
Effectiveness of a novel topical powder on the treatment of traumatic oral ulcers in orthodontic patients: A randomized controlled trial
Rennick, L. A., Campbell, P. M., Naidu, A., Taylor, R. W., & Buschang, P. H. (2015) · The Angle Orthodontist · doi:10.2319/050415-303.1 · Cited by 22
Pseudomonas aeruginosa biofilm hampers murine central wound healing by suppression of vascular epithelial growth factor
Trøstrup, H., Lerche, C. J., Christophersen, L., Thomsen, K., Jensen, P. Ø., Hougen, H. P., Høiby, N., & Moser, C. E. (2017) · International Wound Journal · doi:10.1111/iwj.12846 · Cited by 22
Electrospun gelatin–arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application
Aduba, D. C., An, S., Selders, G. S., Yeudall, W. A., Bowlin, G. L., Kitten, T. O., & Yang, H. (2018) · International Journal of Polymeric Materials · doi:10.1080/00914037.2018.1482466 · Cited by 22
Hydrogen-peroxide generating electrochemical bandage is active in vitro against mono- and dual-species biofilms
Raval, Y. S., Mohamed, A. H., Flurin, L., Mandrekar, J. N., Greenwood‐Quaintance, K. E., Beyenal, H., & Patel, R. (2021) · Biofilm · doi:10.1016/j.bioflm.2021.100055 · Cited by 22
The extracellular adherence protein from Staphylococcus aureus abrogates angiogenic responses of endothelial cells by blocking Ras activation
Sobke, A., Selimovic, D., Orlova, V. V., Hassan, M., Chavakis, T., Athanasopoulos, A. N., Schubert, U., Hussain, M. S., Thiel, G., Preissner, K. T., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-5764fje · Cited by 22
13. Fly Colony Establishment, Quality Control and Improvement
Stadler, F., Johnston, N. P., Butterworth, N. J., & Wallman, J. F. (2022) · Open Book Publishers · doi:10.11647/obp.0300.13 · Cited by 20
11. Bioprospecting and Testing of New Fly Species for Maggot Therapy
Thyssen, P. J., Masiero, F. S., & Stadler, F. (2022) · Open Book Publishers · doi:10.11647/obp.0300.11 · Cited by 20
8. Maggot Debridement
Nigam, Y., & Wilson, M. R. (2022) · Open Book Publishers · doi:10.11647/obp.0300.08 · Cited by 20
17. Distribution Logistics
Stadler, F. (2022) · Open Book Publishers · doi:10.11647/obp.0300.17 · Cited by 20
7. The Natural History of Medicinal Flies
Harvey, M. (2022) · Open Book Publishers · doi:10.11647/obp.0300.07 · Cited by 21
19. The Ethics of Maggot Therapy
Stadler, F. (2022) · Open Book Publishers · doi:10.11647/obp.0300.19 · Cited by 20
6. Clinical Integration of Maggot Therapy
Bullen, B., Sherman, R. A., Chadwick, P. J., & Stadler, F. (2022) · Open Book Publishers · doi:10.11647/obp.0300.06 · Cited by 20
Exploring the therapeutic potential of recombinant human lysozyme: a review on wound management system with antibacterial
Zhao, M., Huang, M.-L., & Li, Z. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1292149 · Cited by 21
How effective is simple mechanical wound debridement in reducing bacterial colonisation? Results of a prospective clinical study
Moelleken, M., Krimphove, S. H., Krefting, F., Benson, S., Rammos, C., Cyrek, A., & Dissemond, J. (2024) · International Wound Journal · doi:10.1111/iwj.14824 · Cited by 21
Pseudomonas aeruginosa and Staphylococcus aureus virulence factors as biomarkers of infection
Sabat, A. J., Pantano, D., Akkerboom, V., Bathoorn, E., & Friedrich, A. W. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0243 · Cited by 21
A multifunctional black phosphorus-based adhesive patch intrinsically induces partial EMT for effective burn wound healing
Wang, X., Tang, X., Li, N., Sun, Y., Yu, R., Zhang, J., Li, D., Yang, B. J., & Sun, H. (2022) · Biomaterials Science · doi:10.1039/d2bm01625g · Cited by 21

Authors: Edwards, R., & Harding, K. G.
Affiliations: Cardiff University (GB)
Corresponding author: Edwards, Ruth
ORCID: Harding, Keith G
Venue: Current Opinion in Infectious Diseases
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-04
Volume: 17
Issue: 2
Pages: 91-96
ISSN: 0951-7375 (ISSN-L)
DOI: 10.1097/00001432-200404000-00004
OpenAlex: W2048602281
Cited by: 1,099
References: 43
Citations by year: 2026: 31 · 2025: 57 · 2024: 76 · 2023: 78 · 2022: 90 · 2021: 98 · 2020: 83 · 2019: 66 · 2018: 58 · 2017: 54 · 2016: 55 · 2015: 51 · 2014: 46 · 2013: 54 · 2012: 50
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Surgery › Surgical site infection prevention
Keywords: wound healing, chronic wounds, wound infection, bacterial colonization, local infection, biofilm, antibiotic resistance, host immune response, bacterial virulence, delayed wound healing
MeSH terms: Bacteria, Chronic Disease, Humans, Wound Healing, Wound Infection, Skin Diseases, Bacterial, Biofilms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bacteria and wound healing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks