Cited by 1,099Wound Healing and TreatmentsBacterial biofilms and quorum sensingSurgical site infection prevention

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Bacteria and wound healing

Edwards, Ruth, Harding, Keith G·2004·Current Opinion in Infectious Diseases

DOI 10.1097/00001432-200404000-00004

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Abstract

PURPOSE OF REVIEW: Wound healing is a complex process with many potential factors that can delay healing. There is increasing interest in the effects of bacteria on the processes of wound healing. All chronic wounds are colonized by bacteria, with low levels of bacteria being beneficial to the wound healing process. Wound infection is detrimental to wound healing, but the diagnosis and management of wound infection is controversial, and varies between clinicians. RECENT FINDINGS: There is increasing recognition of the concept of critical colonization or local infection, when wound healing may be delayed in the absence of the typical clinical features of infection. The progression from wound colonization to infection depends not only on the bacterial count or the species present, but also on the host immune response, the number of different species present, the virulence of the organisms and synergistic interactions between the different species. There is increasing evidence that bacteria within chronic wounds live within biofilm communities, in which the bacteria are protected from host defences and develop resistance to antibiotic treatment. SUMMARY: An appreciation of the factors affecting the progression from colonization to infection can help clinicians with the interpretation of clinical findings and microbiological investigations in patients with chronic wounds. An understanding of the physiology and interactions within multi-species biofilms may aid the development of more effective methods of treating infected and poorly healing wounds. The emergence of consensus guidelines has helped to optimize clinical management.

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Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators
Fuqua, W. C., Winans, S. C., & Greenberg, E. P. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.2.269-275.1994 · Cited by 2,941
The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms
Ceri, H., Olson, M. E., Stremick, C., Read, R. R., Morck, D., & Buret, A. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.6.1771-1776.1999 · Cited by 2,155
Wound Microbiology and Associated Approaches to Wound Management
Bowler, P. G., Duerden, B. I., & Armstrong, D. G. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.2.244-269.2001 · Cited by 2,112
Wound bed preparation: a systematic approach to wound management
Schultz, G. S., Sibbald, R. G., Falanga, V., Ayello, E. A., Dowsett, C., Harding, K. G., Romanelli, M., Stacey, M. C., Téot, L., & Vanscheidt, W. (2003) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.11.s2.1.x · Cited by 1,440
Self-citation
A component of innate immunity prevents bacterial biofilm development
Singh, P. K., Parsek, M. R., Greenberg, E. P., & Welsh, M. J. (2002) · Nature · doi:10.1038/417552a · Cited by 1,026
Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomised controlled trial
Melling, A. C., Ali, B., Scott, E. M., & Leaper, D. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06071-8 · Cited by 712
WOUND INFECTION
Robson, M. C. (1997) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70572-7 · Cited by 643
The validity of the clinical signs and symptoms used to identify localized chronic wound infection
Gardner, S. E., Frantz, R. A., & Doebbeling, B. N. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00178.x · Cited by 415
Biochemical analysis of acute and chronic wound environments
Tarnuzzer, R. W., & Schultz, G. S. (1996) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1996.40307.x · Cited by 372

Show all 43 references

Research works printed but not linked: 9

Dow, 1999, Ostomy/Wound Manage, 45, 23
Krizek, 1967, Surg Forum, 18, 518
Bowler, 2003, Ostomy/Wound Manage, 49, 44
Wall, 2003, Wound Repair Regen, 20, 346
DeBeer, 1994, ioeng, 44, 636
Mertz, 2003, Wounds, 15, 129
Serralta, 2001, Wounds, 13, 29
Harrison-Balestra, 2003, Dermatol Surg, 29, 631
Geronemus, 1975, Arch Dermatol, 111, 1311

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Authors: Edwards, R., & Harding, K. G.
Affiliations: Cardiff University (GB)
Corresponding author: Edwards, Ruth
ORCID: Harding, Keith G
Venue: Current Opinion in Infectious Diseases
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-04
Volume: 17
Issue: 2
Pages: 91-96
ISSN: 0951-7375 (ISSN-L)
DOI: 10.1097/00001432-200404000-00004
OpenAlex: W2048602281
Cited by: 1,099
References: 43
Citations by year: 2026: 31 · 2025: 57 · 2024: 76 · 2023: 78 · 2022: 90 · 2021: 98 · 2020: 83 · 2019: 66 · 2018: 58 · 2017: 54 · 2016: 55 · 2015: 51 · 2014: 46 · 2013: 54 · 2012: 50
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Surgery › Surgical site infection prevention
Keywords: wound healing, chronic wounds, wound infection, bacterial colonization, local infection, biofilm, antibiotic resistance, host immune response, bacterial virulence, delayed wound healing
MeSH terms: Bacteria, Chronic Disease, Humans, Wound Healing, Wound Infection, Skin Diseases, Bacterial, Biofilms

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