Prevention of catheter-associated urinary tract infection
Open accessAbstract
PURPOSE OF REVIEW: The underlying cause of catheter-associated urinary tract infection is biofilm formation by uropathogens on the urinary catheter. Biofilm is a relatively new concept in medicine, and current measures to prevent biofilm formation are inadequate. Considerable work is being done in this area, but little clinical progress has been made. The purpose of this review is to analyze recent publications concerning prevention of catheter-associated urinary tract infection. RECENT FINDINGS: Several recent studies have elucidated aspects of biofilm formation in catheter-associated urinary tract infection. Other researchers are working on methods to disrupt biofilm formation on catheter surfaces. At the same time, the magnitude of the problem of catheter-associated urinary tract infection has increased awareness of the effectiveness of basic infection control measures. A modern approach to infection control may include computerized ordering systems that minimize unnecessary days of catheterization. Finally, consumption of cranberry juice products and bacterial interference are two novel approaches to urinary tract infection prevention. SUMMARY: Biofilm-disrupting strategies offer promise for the future but have little immediate applicability. Implementation of infection control measures to improve catheter function and remove unnecessary catheters can be done at the present time. In general, prevention of catheter-associated urinary tract infection remains an elusive goal. More basic research at the level of pathogenesis is needed so that novel strategies can be designed.
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- Authors
- Trautner, B. W., Hull, R. A., & Darouiche, R. O.
- Affiliations
- Michael E. DeBakey VA Medical Center (US)
- Corresponding author
- Trautner, Barbara W
- ORCID
- Trautner, Barbara W
- Venue
- Current Opinion in Infectious Diseases
- Published
- 2005-02
- Volume
- 18
- Issue
- 1
- Pages
- 37-41
- ISSN
- 0951-7375 (ISSN-L)
- PMC
- PMC2955262
- OpenAlex
- W2111874187
- Cited by
- 99
- References
- 47
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 5 · 2012: 13
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD042014, HD42014)
- Topics
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- catheter-associated urinary tract infection, biofilm formation, urinary catheter, uropathogens, biofilm eradication, infection control, cranberry juice, bacterial interference, catheter dwell time
- MeSH terms
- Catheters, Indwelling, Humans, Urinary Catheterization, Urinary Tract Infections, Infection Control, Biofilms
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