Effects of Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs on Biofilms and Planktonic Cells of Candida albicans
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Prostaglandins are now known to be produced by Candida albicans and may play an important role in fungal colonization. Their synthesis in mammalian cells is decreased by inhibitors of the cyclooxygenase isoenzymes required for prostaglandin formation. In the present study, a catheter disk model system was used to investigate the effects of nonsteroidal anti-inflammatory drugs (all cyclooxygenase inhibitors) on biofilm formation by three strains of C. albicans. Seven of nine drugs tested at a concentration of 1 mM inhibited biofilm formation. Aspirin, etodolac, and diclofenac produced the greatest effects, with aspirin causing up to 95% inhibition. Celecoxib, nimesulide, ibuprofen, and meloxicam also inhibited biofilm formation, but to a lesser extent. Aspirin was active against growing and fully mature (48-h) biofilms; its effect was dose related, and it produced significant inhibition (20 to 80%) at pharmacological concentrations. Simultaneous addition of prostaglandin E(2) abolished the inhibitory effect of 25 or 50 micro M aspirin. At 1 mM, aspirin reduced the viability of biofilm organisms to 1.9% of that of controls. Surviving cells had a wrinkled appearance, as judged by scanning electron microscopy, and consisted of both yeasts and hyphae. Treatment with other cyclooxygenase inhibitors, such as etodolac, resulted in biofilms that consisted almost entirely of yeast cells. In conventional assays for germ tube formation, these drugs produced significant inhibition, whereas aspirin had little effect. Our findings suggest that cyclooxygenase-dependent synthesis of fungal prostaglandin(s) is important for both biofilm development and morphogenesis in C. albicans and may act as a regulator in these physiological processes. Our results also demonstrate that aspirin possesses potent antibiofilm activity in vitro and could be useful in combined therapy with conventional antifungal agents in the management of some biofilm-associated Candida infections.
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Non-steroidal anti-inflammatory drugs (NSAIDs) have been discovered to possess potent antibacterial activities.
“Furthermore, there has been increasing attention to drugs belonging to different pharmacological classes for possible antimicrobial activity, including a number of non-steroidal anti-inflammatory drugs (NSAIDs), which have been discovered to possess potent antibacterial activities [4,5].”
From In vitro analysis of flufenamic acid activity against Candida albicans biofilms (2014) · cites this paper as [4]
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- Authors
- Alem, M. A. S., & Douglas, L. J.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Douglas, L. Julia
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2004-01
- Volume
- 48
- Issue
- 1
- Pages
- 41-47
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC310207
- OpenAlex
- W2153164648
- Cited by
- 205
- References
- 36
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 13 · 2020: 18 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 13 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 7
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida albicans, biofilm formation, aspirin, nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibitors, prostaglandins, prostaglandin E2, antibiofilm activity, germ tube formation, fungal morphogenesis, planktonic cells, etodolac, diclofenac, celecoxib, nimesulide, ibuprofen, meloxicam
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Candida albicans, Culture Media, Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Microscopy, Electron, Scanning, Prostaglandin-Endoperoxide Synthases, Dinoprostone, Cyclooxygenase Inhibitors, Biofilms
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