Comorbidity of psychiatric and substance abuse disorders
Abstract
Comorbid substance abuse is a common problem in psychiatric patients, and may contribute to treatment refractoriness, noncompliance with treatment, and increased health services utilization and expenditure. Rates of substance abuse are highest in patients with schizophrenia and bipolar disorder. This review discusses recent findings with regard to the epidemiology, neurobiology, treatment, and health services delivery for comorbid psychiatric and substance abuse disorders.
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People with psychotic disorders have high rates of nicotine dependence.
“it is well-known that people with psychotic disorders have high rates of nicotine dependence (George and Krystal, 2000).”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as George and Krystal, 2000
Cites
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Co‐Morbidity of Smoking in Patients with Psychiatric and Substance Use Disorders
Kalman, D., Morissette, S. B., & George, T. P. (2005) · The American Journal on Addictions · doi:10.1080/10550490590924728 · Cited by 594 · see citing works
Self-citationNicotinic acetylcholine receptors in neurological and psychiatric diseases
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“Finally, it is well-known that people with psychotic disorders have high rates of nicotine dependence (George and Krystal, 2000).”
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- Authors
- George, T. P., & Krystal, J. H.
- Affiliations
- Yale University (US)
- Corresponding author
- George, Tony P.
- Venue
- Current Opinion in Psychiatry
- Published
- 2000-05
- Volume
- 13
- Issue
- 3
- Pages
- 327-331
- ISSN
- 0951-7367 (ISSN-L)
- OpenAlex
- W2317429493
- Cited by
- 106
- References
- 6
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 56 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 1 · 2012: 4
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- psychiatric comorbidity, substance abuse, schizophrenia, bipolar disorder, treatment refractoriness, treatment non-adherence, health care utilization, health care costs, addiction treatment, health care delivery
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