The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Amygdala core nuclei volumes are decreased in recurrent major depression
Abstract
The amygdala is a key structure in the brain's integration of emotional meaning with perception and experience. Patients with depression have impaired functioning in emotional tasks involving the amygdala, and have abnormal resting amygdala blood flow. To better understand the anatomical basis for these functional changes we measured the volumes of the total amygdala and of the core amygdala nuclei in 20 patients with a history of depression and 20 pair-wise matched controls. Depressed subjects had bilaterally reduced amygdala core nuclei volumes and no significant differences in total amygdala volumes or in whole brain volumes. Since patients with a depression history have bilateral hippocampal volume reduction the volume loss in this closely related structure suggests a shared effect on both structures, potentially glucocorticoid-induced neurotoxicity mediated by the extensive reciprocal glutamatergic connections.
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“Dysfunction in the activity of these regions is strongly implicated in major depressive disorder (Sheline et al., 1998; Videbech and Ravnkilde, 2004).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Sheline et al., 1998
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Cites
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MORPHOMETRY OF THE SYLVIAN FISSURE AND THE CORPUS CALLOSUM, WITH EMPHASIS ON SEX DIFFERENCES
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The Neurophysiology of Glial Cells
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Research works printed but not linked: 1
- 1997, Abstr Soc Neurosci, 23, 588.8 8
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Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
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The Corticosteroid Receptor Hypothesis of Depression
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Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Metadata
- Authors
- Sheline, Y. I., Gado, M. H., & Price, J. L.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Sheline, Yvette I.
- Venue
- NeuroReport
- Published
- 1998-06
- Volume
- 9
- Issue
- 9
- Pages
- 2023-2028
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2048738245
- Semantic Scholar
- a28790d3fb604932494489fedfac499bb0911161
- Cited by
- 472
- References
- 7
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 14 · 2020: 8 · 2019: 12 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 27 · 2013: 13 · 2012: 29
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, recurrent major depressive disorder, brain atrophy, hippocampus, emotional processing
- MeSH terms
- Adult, Aged, Aged, 80 and over, Amygdala, Brain, Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Recurrence
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