Cited by 278Treatment of Major DepressionStress Responses and CortisolNeural and Behavioral Psychology Studies

Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects

Frodl, Thomas, Meisenzahl, Eva Maria, Zetzsche, Thomas, Born, Christine, Jäger, Markus, Groll, Constanze, Bottlender, Ronald, Leinsinger, Gerda +1 more·2003·Biological Psychiatry

Abstract

Background The aim of our study was to test the hypothesis that amygdala volumes are reduced in patients with recurrent major depression compared with first episode patients.Methods Using structural magnetic resonance imaging, we compared 30 inpatients with first-episode depression and 27 inpatients with recurrent major depression (DSM-IV) with healthy volunteer subjects from the local community matched for age, gender, and handedness.Results Patients with first-episode depression showed enlarged amygdala volumes compared with patients with recurrent major depression and healthy control subjects. No significant differences were found between patients with recurrent depression and healthy control subjects. No significant correlations were found between amygdala volumes and age of onset, illness duration, or severity of depression.Conclusions Larger amygdala volumes in patients with first-episode depression may result from higher amygdala metabolism and blood flow. Additionally, disease progression with stress-related excitotoxic processes during recurrent depressive episodes might result in decreased amygdala volumes. Prospective investigations to investigate amygdala changes during the course of depression are needed.

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Crossref · 10.1016/s0006-3223(02)01474-9

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Authors
Frodl, T., Meisenzahl, E. M., Zetzsche, T., Born, C., Jäger, M., Groll, C., Bottlender, R., Leinsinger, G., & Möller, H.-J.
Affiliations
Ludwig-Maximilians-Universität München (DE)
Corresponding author
Meisenzahl, Eva Maria
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2003-02
Volume
53
Issue
4
Pages
338-344
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2009782994
Cited by
278
References
41
Citations by year
2026: 7 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 13 · 2020: 18 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 8 · 2015: 11 · 2014: 24 · 2013: 9 · 2012: 13
FWCI
6.64
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
amygdala volume, first-episode depression, recurrent major depressive disorder, brain structural changes, blood flow, excitotoxicity, age of onset, disease duration, depression severity
MeSH terms
Adult, Aging, Amygdala, Major Depressive Disorder, Depressive Disorder, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Recurrence, Age of Onset, Disease Progression

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