The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Tracking Alzheimerʼs disease in transgenic mice using fluorodeoxyglucose autoradiography
Abstract
While transgenic mice have great promise in the study of Alzheimer's disease (AD), uncertainties remain about the extent to which they provide a model of the disorder or the best way to characterize disease progression. Using fluorodeoxyglucose (FDG) autoradiography, we found that transgenic mice over-expressing a mutant form of the human amyloid precursor protein have preferentially and progressively reduced activity in the posterior cingulate cortex and relatively spared activity in visual cortex, sensorimotor cortex, cerebellum and brain stem, a pattern previously demonstrated in FDG PET studies of persons with Alzheimer's disease, Brain imaging of posterior cingulate activity could provide an indicator of AD in suitable animals, helping to clarify disease mechanisms and screen candidate treatments.
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“This conjecture is supported further by the increased predilection in early AD for β-amyloid to accumulate in the neocortex rather than the hippocampal formation (2, 6) and by reductions in METglu observed in transgenic mouse models overproducing amyloid (44).”
From Prediction of cognitive decline in normal elderly subjects with 2-[ 18 F]fluoro-2-deoxy- d -glucose/positron-emission tomography (FDG/PET) (2001) · cites this paper as [44]
Citations
Cites
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Cingulate cortex of the rhesus monkey: I. Cytoarchitecture and thalamic afferents
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Posterior cingulate cortex in Alzheimer's disease
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Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease
Gonzalez-Lima, F. (2013) · Medical Entomology and Zoology · Cited by 74
Self-citationLaminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease
Vogt, B. A., Hoesen, G. W. V., & Vogt, L. J. (1990) · Acta Neuropathologica · doi:10.1007/bf00307624 · Cited by 74
Functional mapping of the rat brain during drinking behavior: A fluorodeoxyglucose study
Gonzalez-Lima, F., Helmstetter, F. J., & Agudo, J. A. G. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90256-f · Cited by 58
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- 1994, Lancet, 344, 895
- 1997, Hippocampus, 7, 146
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Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052
de Leon, M. J., Convit, A., Wolf, O. T., Tarshish, C. Y., DeSanti, S., Rusinek, H., Tsui, W., Kandil, E., Scherer, A. J., Roche, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191044198 · Cited by 629
Reiman, E. M., Caselli, R. J., Chen, K., Alexander, G. E., Bandy, D., & Frost, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061509598 · Cited by 467
Self-citationThe role of glucose transporters in brain disease: Diabetes and Alzheimer’s disease
Shah, K., DeSilva, S., & Abbruscato, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012629 · Cited by 288
Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment
Valla, J., Schneider, L., Niedzielko, T., Coon, K. D., Caselli, R., Sabbagh, M. N., Ahern, G. L., Baxter, L., Alexander, G., Walker, D. G., et al. (2006) · Mitochondrion · doi:10.1016/j.mito.2006.10.004 · Cited by 159
Metadata
- Authors
- Reiman, E. M., Uecker, A., Gonzalez-Lima, F., Minear, D., Chen, K., Callaway, N. L., Berndt, J. D., & Games, D.
- Affiliations
- University of Arizona (US)
- The University of Texas at Austin (US)
- Venue
- NeuroReport
- Published
- 2000-04
- Volume
- 11
- Issue
- 5
- Pages
- 987-991
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2061253981
- Cited by
- 62
- References
- 12
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, transgenic mice, amyloid precursor protein, brain glucose metabolism, posterior cingulate cortex, visual cortex, disease progression, animal models of Alzheimer's disease, neuroimaging
- MeSH terms
- Age Factors, Alzheimer Disease, Animals, Brain, Carbon Radioisotopes, Energy Metabolism, Glucose, Gyrus Cinguli, Mice, Transgenic, Radionuclide Imaging, Fluorodeoxyglucose F18, Mice
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