Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment
Open accessAbstract
Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.
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Activity of mitochondrial respiratory complexes is decreased in platelet and lymphocyte mitochondria, with significant changes in Cx IV (COX) activity, decreased in cells from advanced AD patients and MCI individuals.
“the activity of mitochondrial respiratory complexes was also demonstrated to be decreased in platelet and lymphocyte mitochondria, evidencing significative changes in Cx IV (or COX) activity, that is not only decreased in cells derived from advanced AD patients, but also from MCI individuals [61].”
From Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic Strategies (2023) · cites this paper as [61]
COX activity is lower in MCI subject platelet mitochondria than in control subject platelet mitochondria.
“COX activity is lower in MCI subject platelet mitochondria than it is in platelet mtiochondria from control subjects [130].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [130]
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- Authors
- Valla, J., Schneider, L., Niedzielko, T., Coon, K. D., Caselli, R., Sabbagh, M. N., Ahern, G. L., Baxter, L., Alexander, G., Walker, D. G., & Reiman, E. M.
- Affiliations
- Barrow Neurological Institute (US)
- Translational Genomics Research Institute (US)
- Mayo Clinic in Arizona (US)
- University of Arizona (US)
- Arizona State University (US)
- Arizona Alzheimer’s Consortium (US)
- Corresponding author
- Valla, Jon
- ORCID
- Venue
- Mitochondrion
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 6
- Issue
- 6
- Pages
- 323-330
- ISSN
- 1567-7249 (ISSN-L)
- PMC
- PMC1864936
- OpenAlex
- W2037103764
- Cited by
- 159
- References
- 57
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 12 · 2020: 11 · 2019: 3 · 2018: 13 · 2017: 10 · 2016: 14 · 2015: 4 · 2014: 5 · 2013: 14 · 2012: 17
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Mitochondrion (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mayo Clinic
- National Institute on Aging (P30AG019610)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, mild cognitive impairment, platelet mitochondria, mitochondrial dysfunction, respiratory chain complexes, cytochrome bc1 complex, cytochrome c oxidase, early-stage dementia
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Blood Platelets, Cognition Disorders, Female, Humans, Male, Mitochondria
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