Tracking Alzheimerʼs disease in transgenic mice using fluorodeoxyglucose autoradiography

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123

Cingulate cortex of the rhesus monkey: I. Cytoarchitecture and thalamic afferents

Vogt, B. A., Pandya, D. N., & Rosene, D. L. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902620207 · Cited by 604

Distribution of cerebral degeneration in Alzheimer's disease: A clinico-pathological study

Brun, A., & Gustafson, L. (1976) · Archiv f�r Psychiatrie und Nervenkrankheiten · doi:10.1007/bf00367450 · Cited by 397

Posterior cingulate cortex in Alzheimer's disease

MINOSHIMA, S. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92871-1 · Cited by 316

Cellular Bases of Brain Energy Metabolism and Their Relevance to Functional Brain Imaging: Evidence for a Prominent Role of Astrocytes

Magistretti, P. J., & Pellerin, L. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.1.50 · Cited by 243

Prenatal exposure to moderate levels of ethanol can have long-lasting effects on hippocampal synaptic plasticity in adult offspring

Sutherland, R. J., McDonald, R. J., & Savage, D. D. (1997) · Hippocampus · doi:10.1002/(sici)1098-1063(1997)7:2 · Cited by 178

Hippocampal control of cingulate cortical and anterior thalamic information processing during learning in rabbits

Gabriel, M., Sparenborg, S., & Stolar, N. (1987) · Experimental Brain Research · doi:10.1007/bf00269462 · Cited by 99

Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease

Gonzalez-Lima, F. (2013) · Medical Entomology and Zoology · Cited by 74

Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease

Vogt, B. A., Hoesen, G. W. V., & Vogt, L. J. (1990) · Acta Neuropathologica · doi:10.1007/bf00307624 · Cited by 74

Functional mapping of the rat brain during drinking behavior: A fluorodeoxyglucose study

Gonzalez-Lima, F., Helmstetter, F. J., & Agudo, J. A. G. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90256-f · Cited by 58

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052

Prediction of cognitive decline in normal elderly subjects with 2-[ 18 F]fluoro-2-deoxy- d -glucose/positron-emission tomography (FDG/PET)

de Leon, M. J., Convit, A., Wolf, O. T., Tarshish, C. Y., DeSanti, S., Rusinek, H., Tsui, W., Kandil, E., Scherer, A. J., Roche, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191044198 · Cited by 629

Declining brain activity in cognitively normal apolipoprotein E ɛ4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease

Reiman, E. M., Caselli, R. J., Chen, K., Alexander, G. E., Bandy, D., & Frost, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061509598 · Cited by 467

The role of glucose transporters in brain disease: Diabetes and Alzheimer’s disease

Shah, K., DeSilva, S., & Abbruscato, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012629 · Cited by 288

Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Valla, J., Schneider, L., Niedzielko, T., Coon, K. D., Caselli, R., Sabbagh, M. N., Ahern, G. L., Baxter, L., Alexander, G., Walker, D. G., et al. (2006) · Mitochondrion · doi:10.1016/j.mito.2006.10.004 · Cited by 159

Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer’s disease

Dickerson, B. C., & Sperling, R. A. (2005) · Neurotherapeutics · doi:10.1602/neurorx.2.2.348 · Cited by 159

Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer’s disease

Robinson, S. R., & Bishop, G. M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00342-6 · Cited by 155

Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease

Poisnel, G., Hérard, A., Tayara, N. E. T. E., Bourrin, E., Volk, A., Kober, F., Delatour, B., Delzescaux, T., Debeir, T., Rooney, T., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.026 · Cited by 123

VECTor: A Preclinical Imaging System for Simultaneous Submillimeter SPECT and PET

Goorden, M. C., van der Have, F., Kreuger, R., Ramakers, R. M., Vastenhouw, B., Burbach, J. P. H., Booij, J., Molthoff, C. F. M., & Beekman, F. J. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.109538 · Cited by 115

Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models

Nicholson, R. M., Kusne, Y., Nowak, L. A., LaFerla, F. M., Reiman, E. M., & Valla, J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.084 · Cited by 107

Preclinical Evidence of Alzheimer Changes

Petrie, E. C., Cross, D. J., Galasko, D. R., Schellenberg, G. D., Raskind, M. A., Peskind, E. R., & Minoshima, S. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.59 · Cited by 102

Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease

Kuntner, C., Kesner, A., Bauer, M., Kremslehner, R., Wanek, T., Mandler, M., Karch, R., Stanek, J., Wolf, T., Müller, M., et al. (2009) · Molecular Imaging and Biology · doi:10.1007/s11307-009-0198-z · Cited by 90

Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer's disease

Luo, F. R., Rustay, N. R., Ebert, U., Hradil, V. P., Cole, T. B., Llano, D. A., Mudd, S. R., Zhang, Y., Fox, G. B., & Day, M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.08.005 · Cited by 89

In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography

Rojas, S., Herance, J. R., Gispert, J. D., Abad, S., Llongarriu, È. T., Jiménez, X., Pareto, D., Perpiñá, U., Sarroca, S., Rodrı́guez, E., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.027 · Cited by 88

Metabolic Dysfunction in Alzheimer’s Disease: From Basic Neurobiology to Clinical Approaches

Clarke, J. R., Ribeiro, F. C., Frozza, R. L., Felice, F. G. D., & Lourenco, M. V. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179911 · Cited by 93

Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse

Macdonald, I. R., DeBay, D. R., Reid, G. A., O’Leary, T. P., Jollymore, C. T., Mawko, G., Burrell, S., Martin, E., Bowen, C. V., Brown, R. E., et al. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140505111354 · Cited by 79

Reduction of Glucose Metabolism in Olfactory Bulb is an Earlier Alzheimer's Disease-related Biomarker in 5XFAD Mice

Xiao, N., Zhang, J., Zhou, M., Wei, Z., Wu, X., Dai, X., Zhu, Y., & Chen, X. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.162507 · Cited by 69

Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18 F-FDG and 18 F-DPA-714 PET imaging

Helin, J. S., Lopez‐Picon, F. R., Majidi, R. A., Eskola, O., Krzyczmonik, A., Keller, T., Löyttyniemi, E., Solin, O. H., Rinne, J. O., & Haaparanta‐Solin, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16677990 · Cited by 66

Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease

Gonzalez-Lima, F., Berndt, J. D., Valla, J. E., Games, D., & Reiman, E. M. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00018 · Cited by 62

Regional hypometabolism in the 3xTg mouse model of Alzheimer's disease

Adlimoghaddam, A., Snow, W. M., Stortz, G., Perez, C., Djordjevic, J., Goertzen, A. L., Ko, J. H., & Albensi, B. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.03.008 · Cited by 61

Beneficial network effects of methylene blue in an amnestic model

Riha, P. D., Rojas, J. C., & Gonzalez-Lima, F. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.023 · Cited by 60

Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation

Schöll, M., Almkvist, O., Axelman, K., Stefanova, E. D., Wall, A. E., Westman, E., Långström, B., Lannfelt, L., Graff, C., & Nordberg, A. K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.016 · Cited by 57

Water maze training in aged rats: effects on brain metabolic capacity and behavior

Villarreal, J., Gonzalez-Lima, F., Berndt, J. D., & Barea-Rodrı́guez, E. J. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02545-3 · Cited by 53

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

Giuffrida, M. L., Tomasello, M. F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Di Pietro, P., Pappalardo, G., Attanasio, F., Chiechio, S., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00297 · Cited by 52

Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease

Dubois, A., Hérard, A., Delatour, B., Hantraye, P., Bonvento, G., Dhénain, M., & Delzescaux, T. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.074 · Cited by 57

Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer’s disease

Cisternas, P., & Inestrosa, N. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.004 · Cited by 52

Drug Access to the Central Nervous System in Alzheimer’s Disease: Preclinical and Clinical Insights

Mehta, D. C., Short, J. L., Hilmer, S. N., & Nicolazzo, J. A. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1522-0 · Cited by 47

Linking Brain Imaging and Genomics in the Study of Alzheimer's Disease and Aging

Reiman, E. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.011 · Cited by 39

Age- and transgene-related changes in regional cerebral metabolism in PSAPP mice

Valla, J., Schneider, L. E., & Reiman, E. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.097 · Cited by 38

In vivo molecular neuroimaging of glucose utilization and its association with fibrillar amyloid-β load in aged APPPS1-21 mice

Waldron, A., Wintmolders, C., Bottelbergs, A., Kelley, J. B., Schmidt, M. E., Stroobants, S. G., Langlois, X., & Staelens, S. G. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0158-6 · Cited by 34

Imaging-Based Measures of Disease Progression in Clinical Trials of Disease-Modifying Drugs for Alzheimer Disease

Matthews, B. R., Siemers, E., & Mozley, P. D. (2003) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200303000-00005 · Cited by 34

FDG autoradiography reveals developmental and pathological effects of mutant amyloid in PDAPP transgenic mice

Valla, J., Gonzalez-Lima, F., & Reiman, E. M. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.02.003 · Cited by 37

Effects of Image Resolution on Autoradiographic Measurements of Posterior Cingulate Activity in PDAPP Mice: Implications for Functional Brain Imaging Studies of Transgenic Mouse Models of Alzheimer's Disease

Valla, J. E., Chen, K., Berndt, J. D., Gonzalez-Lima, F., Cherry, S. R., Games, D., & Reiman, E. M. (2002) · NeuroImage · doi:10.1006/nimg.2002.1080 · Cited by 32

Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression

Teipel, S. J., Buchert, R., Thome, J., Hampel, H. J., & Pahnke, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.004 · Cited by 31

Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice

Poirier, G. L., Amin, E., Good, M. A., & Aggleton, J. P. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.025 · Cited by 30

Tracking the decline in cerebral glucose metabolism in persons and laboratory animals at genetic risk for Alzheimer's disease

Reiman, E. M., Caselli, R. J., Alexander, G. E., & Chen, K. (2001) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(01)00006-8 · Cited by 28

Prediction of Progression in Patients with Mild Cognitive Impairment Using IMP-SPECT.

Okamura, N., Shinkawa, M., Arai, H., Matsui, T., Nakajo, K., Maruyama, M., Hu, X. S., & Sasaki, H. (2000) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.37.974 · Cited by 29

Use of Genetically Engineered Mice in Drug Discovery and Development: Wielding Occam's Razor to Prune the Product Portfolio

Bolon, B. N., & Galbreath, E. J. (2002) · International Journal of Toxicology · doi:10.1080/10915810252826019 · Cited by 30

Alzheimer's disease biomarkers: correspondence between human studies and animal models

Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.010 · Cited by 27

Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease

Armstrong, P., Güngör, H., Anongjanya, P., Tweedy, C., Parkin, E. T., Johnston, J., Carr, I., Dawson, N., & Clapcote, S. J. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01852-z · Cited by 25

Alzheimer's disease biomarkers in animal models: closing the translational gap.

Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Europe PMC (PubMed Central) · Cited by 24

Significant Reduction of the GLUT3 Level, but not GLUT1 Level, Was Observed in the Brain Tissues of Several Scrapie Experimental Animals and Scrapie-Infected Cell Lines

Yan, Y., Zhang, J., Wang, K., Xu, Y., Ren, K., Zhang, B., Shi, M., Chen, C., Shi, Q., Tian, C., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8574-8 · Cited by 18

Broad-Based Nutritional Supplementation in 3xTg Mice Corrects Mitochondrial Function and Indicates Sex-Specificity in Response to Alzheimer's Disease Intervention

Wolf, A. B., Braden, B. B., Bimonte‐Nelson, H. A., Kusne, Y. N., Young, N., Engler-Chiurazzi, E. B., Garcia, A. N., Walker, D. G., Moses, G. S. D., Tran, V.-H., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120478 · Cited by 16

In Vivo Imaging Biomarkers in Mouse Models of Alzheimer's Disease: Are We Lost in Translation or Breaking Through?

Delatour, B., Epelbaum, S., Petiet, A., & Dhénain, M. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/604853 · Cited by 18

Longitudinal Assessment of a Transgenic Animal Model of Tauopathy by FDG-PET Imaging

de Cristóbal, J., García‐García, L., Delgado, M., Pérez, M., Pozo, M. A., & Medina, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132276 · Cited by 11

Transgenic mice expressing the human C99 terminal fragment of βAPP: effects on cytochrome oxidase activity in skeletal muscle and brain

Strazielle, C., Dumont, M., Fukuchi, K.-I., & Lalonde, R. (2004) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2004.03.009 · Cited by 8

Acute toxicity of two Alzheimer’s disease radiopharmaceuticals: FDDNP and IMPY

Chang, K., Chen, C., Lee, S.-Y., & Wang, H.-E. (2009) · Drug and Chemical Toxicology · doi:10.1080/01480540903127324 · Cited by 7

Construction of mouse brain MRI templates using SPM 99

Lin, L., Chen, K., Alexander, G. E., He, J., Valla, J. E., Galons, J., Hauss‐Wegrzyniak, B., & Reiman, E. M. (2003) · IFAC Proceedings Volumes · doi:10.1016/s1474-6670(17)33484-5 · Cited by 6

Cerebral lactate metabolism and memory: Implications for Alzheimer's disease

Harris, R. A. (2017) · Scholarship@Western (Western University) · Cited by 3

Transport of Glucose by the Plasma Membrane Affects the Removal and Concentration of Ca2+ at Rest in Neurons – Implications of a Condition Prior to Alzheimer’s Disease?

Alves, V. S., Arcísio-Miranda, M., Carrettiero, D. C., & Oliveira, F. A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.01.048 · Cited by 3

Positron Emission Tomography and Magnetic Resonance Imaging in the Study of Cognitively Normal Persons at Differential Genetic Risk for Alzheimer’s Dementia

Reiman, E. M., Caselli, R. J., Chen, K., & Alexander, G. E. (2004) · Springer eBooks · doi:10.1007/978-3-642-59300-0_12 · Cited by 3

Genetically Engineered Animals

Bolon, B. N. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00081-x · Cited by 2

A Monte-Carlo Simulation Package, Multiple Comparison Corrections and Power Estimation Incorporating Secondary Supportive Evidence

Chen, K., Reiman, E. M., & Alexander, G. E. (2007) · ICME International Conference on Complex Medical Engineering (CME) · doi:10.1109/iccme.2007.4381872 · Cited by 1

Le diagnostic de la maladie d’Alzheimer : l’apport de la recherche préclinique

Delatour, B., & Dhénain, M. (2008) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)32835-3 · Cited by 2

A new paradigm for testing AD drugs – neuroimaging biomarkers as surrogate outcomes homologous in animals and humans

Marizzoni, M., Forloni, G., & Frisoni, G. B. (2013) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2013.09.003

Review Article Alzheimer's disease biomarkers in animal models: closing the translational gap

Sabbagh, J. J., Kinney, J. W., Cummings, J. L., & Ruvo, L. (2013)

Transgenic Mouse (Tg2576) Is an Ideal Model for the Biological Characterization of [18F]-FDDNP for Identifying Alzheimer’s Disease

Chang, K., Lee, S.-Y., & Chen, C.-C. (2015) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2015.312001

Age Related Changes in Cognition and Brain: A Focus on Progestogens

Braden, B. B. (2012)

Molecular Imaging in Alzheimer Clinical Trials

Schmidt, M. E., Matthews, D. C., & Staelens, S. G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00020-4

Epilepsy in Models of Alzheimer’s Disease

Tanila, H., & Pitkänen, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804066-9.00071-7 · Cited by 1

Imaging CNS Disease States: Alzheimer’s Disease

Dickerson, B. C. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0134-7_19

FDG autoradiography reveals developmental and pathological effects of mutant amyloid in PDAPP transgenic mice

Valla, J., Gonzalez-Lima, F., & Reiman, E. M. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.02.003 · Cited by 37

Effects of Image Resolution on Autoradiographic Measurements of Posterior Cingulate Activity in PDAPP Mice: Implications for Functional Brain Imaging Studies of Transgenic Mouse Models of Alzheimer's Disease

Valla, J. E., Chen, K., Berndt, J. D., Gonzalez-Lima, F., Cherry, S. R., Games, D., & Reiman, E. M. (2002) · NeuroImage · doi:10.1006/nimg.2002.1080 · Cited by 32

Age- and transgene-related changes in regional cerebral metabolism in PSAPP mice

Valla, J., Schneider, L. E., & Reiman, E. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.097 · Cited by 38

[P‐122]: Regional cerebral metabolism in PSAPP double‐transgenic mice changes with age and genotype

Valla, J., Schneider, L. E., & Reiman, E. M. (2005) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2005.06.195

Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models

Nicholson, R. M., Kusne, Y., Nowak, L. A., LaFerla, F. M., Reiman, E. M., & Valla, J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.084 · Cited by 107