GABA-A antagonist causes dramatic expansion of tuning in primary auditory cortex
Abstract
Responses from 80 neurons in primary auditory cortex of anesthetized chinchillas were investigated before and during iontophoresis of bicuculline (BIC), a GABA-A antagonist. BIC caused a significant increase in the spontaneous discharge rate (SR) and driven firing rate in most neurons. Threshold decreased in many neurons and the excitatory response area expanded significantly above and below the neuron's characteristic frequency (CF). These results indicate that many neurons in primary auditory cortex receive excitatory inputs from a much broader frequency range than previously believed. GABA-A mediated inhibition can significantly alter the excitability and tuning of auditory cortex and could contribute significantly to cortical plasticity due to experience and cochlear pathology.
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Reduced cortical GABA-A mediated inhibition in Fmr1 KO cortex may also contribute to broader tuning curves (Wang et al., 2000).
“Reduced cortical GABA-A mediated inhibition observed in Fmr1 KO cortex may also contribute to broader tuning curves in the Fmr1 KO mice (Wang et al., 2000).”
From Matrix metalloproteinase-9 deletion rescues auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome (2016) · cites this paper as Wang et al., 2000
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- Authors
- Wang, J., Caspary, D., & Salvi, R. J.
- Affiliations
- University at Buffalo, State University of New York (US)
- SIU Medicine (US)
- Venue
- NeuroReport
- Published
- 2000-04
- Volume
- 11
- Issue
- 5
- Pages
- 1137-1140
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1968519746
- Cited by
- 145
- References
- 12
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 4 · 2012: 4
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01dc003600-05)
- National Institute on Deafness and Other Communication Disorders (P01 DC 03600-01A1)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- primary auditory cortex, bicuculline, frequency tuning, characteristic frequency, spontaneous discharge rate, cortical inhibition, neuronal excitability, cortical plasticity, chinchilla
- MeSH terms
- Acoustic Stimulation, Animals, Auditory Cortex, Auditory Threshold, Bicuculline, Chinchilla, gamma-Aminobutyric Acid, Neuronal Plasticity, Neurons, Receptors, GABA-A, GABA Antagonists, GABA-A Receptor Antagonists
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