Oxytocin receptors in non-human primate brain visualized with monoclonal antibody
Abstract
The identity of putative oxytocin receptors visualized in autoradiographic studies of primate brain is unclear because the ligand used is much less selective in primate than rodent brains. This study tests the feasibility of utilizing a new monoclonal antibody (MoAb) developed against human uterine OTRs to visualize OTRs in primate brain. A block containing ventral hypothalamus of cynomolgus macaque brain, paraformaldehyde, glutaraldehyde-fixed and paraffin-embedded, and positive control tissue (human endometrium) were sectioned at 8 microm and studied with immunohistochemistry. OTRs were located in fibers in septal nucleus and in both cell bodies and fibers of preoptic area. These results indicate that OTRs in primate brain may be visualized with this MoAb, and are located in primate brain sites linked to the regulation of social behavior.
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Macaca OTR was less widely distributed in the social-decision making network compared to V1aR.
“Macaca OTR was less widely distributed in the social-decision making network compared to V1aR (Boccia et al., 2001; Freeman et al., 2014a).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Boccia et al., 2001
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The oxytocin receptor: from intracellular signaling to behavior
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Immunohistochemical localization of oxytocin receptors in human brain
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“Two publications have used immunohistochemistry (IHC) with an OXTR antibody to identify areas of OXTR expression in the macaque brain (Boccia et al., 2001) and in human brain tissue (Boccia et al., 2013).”
MethodBoccia, M. L., Goursaud, A.-P. S., Bachevalier, J., Anderson, K. D., & Pedersen, C. A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.009 · Cited by 136 · see citing works
Self-citationNeuropeptide diversity and the regulation of social behavior in New World primates
French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66 · see citing works
- Authors
- Boccia, M. L., Panicker, A. K., Pedersen, C., & Petrusz, P.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Neuroreport
- Published
- 2001-06
- Volume
- 12
- Issue
- 8
- Pages
- 1723-1726
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2045594740
- Cited by
- 21
- References
- 21
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh056243-03)
- National Institute of Mental Health (MH56243)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (#HD03110, P30HD003110)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin receptor, non-human primate brain, cynomolgus macaques, monoclonal antibodies, ventral hypothalamus, septal nuclei, preoptic area, social behavior regulation, receptor localization
- MeSH terms
- Animals, Antibodies, Monoclonal, Brain, Humans, Immunohistochemistry, Macaca fascicularis, Preoptic Area, Septum Pellucidum, Receptors, Oxytocin
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