Molecular aspects of monogamy
Abstract
Comparative studies of monogamous and nonmonogamous voles demonstrate species differences in the regional expression of oxytocin (OT) receptors in the brain. These species differences have not been observed with other neurotransmitter receptors (except vasopressin). Species differences for OT receptor distribution were also observed in other microtine and murine species selected as monogamous or promiscuous. These chemical neuroanatomic differences appear to be functionally relevant, as treatments with selective OT agonists and antagonists influence those behaviors that appear critical to pair bonding in the monogamous prairie vole. To investigate the mechanism controlling tissue-specific expression of OT receptors, we sequenced the OT receptor gene in both prairie voles and montane voles. The findings are inconclusive. Although both species differ markedly from rat and human in their regulatory (but not their coding) sequences, the species show very subtle differences from each other. Ongoing studies are investigating the consequences of these subtle differences between prairie and montane voles. At the same time, several transactivating factors that might influence OT receptor expression need to be explored. NOTE ADDED IN PROOF: The rat oxytocin receptor gene sequence, cited in FIGURES 4 and 5, was based on an error published in ref. 22. The corrected sequence has now been published (Rosen et al. 1996. Proc. Natl. Acad. Sci USA 93: 12501). The correct sequence shows greater homology with the vole oxytocin receptor gene sequences, but the remaining differences support the argument made herein for species differences in regional receptor expression.
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Oxytocin is a nonapeptide hormone associated with affiliative bonding in mammals and mediates social behavior, pair-bonding, and parental attachment across species.
“OT is a nonapeptide hormone associated with affiliative bonding in mammals (Insel et al., 1997) that is known to mediate social behavior, pair-bonding, and parental attachment across a variety of species (Carter, 1998).”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Insel et al., 1997
Cites
Kleiman, D. G. (1977) · The Quarterly Review of Biology · doi:10.1086/409721 · Cited by 1,436 · see citing works
Swanson, L. W., & Kuypers, H. G. J. M. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901940306 · Cited by 1,413 · see citing works
Synthesis, transport, and release of posterior pituitary hormones
Brownstein, M. J., Russell, J. T., & Gainer, H. (1980) · Science · doi:10.1126/science.6153132 · Cited by 838 · see citing works
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833 · see citing works
Self-citationStructure and expression of a human oxytocin receptor
Kimura, T., Tanizawa, O., Mori, K., Brownstein, M., & Okayama, H. (1992) · Nature · doi:10.1038/356526a0 · Cited by 631 · see citing works
Physiological substrates of mammalian monogamy: The prairie vole model
Sue Carter, C., Courtney Devries, A., & Getz, L. L. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00070-h · Cited by 615 · see citing works
Insel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528 · see citing works
Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487 · see citing works
Self-citationWILLIAMS, J. (1992) · Hormones and Behavior · doi:10.1016/0018-506x(92)90004-f · Cited by 471 · see citing works
Insel, T., Wang, Z., & Ferris, C. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05381.1994 · Cited by 454 · see citing works
Self-citationCarter, C. S. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80176-9 · Cited by 417 · see citing works
Social organization of the prairie vole (Microtus ochrogaster)
Getz, L. L., McGuire, B., Pizzuto, T., Hofmann, J. E., & Frase, B. (1993) · Journal of Mammalogy · doi:10.2307/1381904 · Cited by 350 · see citing works
Social organization in free-living prairie voles, Microtus ochrogaster
Getz, L. L., & Hofmann, J. E. (1986) · Behavioral Ecology and Sociobiology · doi:10.1007/bf00300004 · Cited by 239 · see citing works
Tol, H. H. M. V., Bolwerk, E., LlU, B., & Burbach, J. P. H. (1988) · Endocrinology · doi:10.1210/endo-122-3-945 · Cited by 226 · see citing works
Vasopressin and oxytocin release in the brain – a synaptic event
Buijs, R. M., & Heerikhuize, J. J. V. (1982) · Brain Research · doi:10.1016/0006-8993(82)90979-9 · Cited by 218 · see citing works
Mating in the monogamous male: Behavioral consequences
Insel, T. R., Preston, S., & Winslow, J. T. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00362-9 · Cited by 215 · see citing works
Self-citationInsel, T. R., Gelhard, R., & Shapiro, L. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90321-e · Cited by 209 · see citing works
Self-citationTribollet, E., Audigier, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90232-z · Cited by 203 · see citing works
Structure, characterization, and expression of the rat oxytocin receptor gene.
Rozen, F., Russo, C., Banville, D. L., & Zingg, H. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.1.200 · Cited by 191 · see citing works
Kendrick, K. M., Keverne, E. B., Baldwin, B. A., & Sharman, D. F. (2008) · Neuroendocrinology · doi:10.1159/000124638 · Cited by 187 · see citing works
Insel, T. R. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00445.x · Cited by 164 · see citing works
Self-citationShapiro, L. E., & Insel, T. R. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230502 · Cited by 128 · see citing works
Self-citationThe comparative psychology of monogamy.
Dewsbury, D. A. (1987) · PubMed · Cited by 121 · see citing works
Gonadal steroids have paradoxical effects on brain oxytocin receptors
Insel, T. R., Young, L., Witt, D. M., & Crews, D. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00531.x · Cited by 113 · see citing works
Self-citationVoorn, P., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90809-0 · Cited by 112 · see citing works
Central Nervous System Distribution of Vasopressin, Oxytocin, and Neurophysin
Sofroniew, M. V., & Weindl, A. (1981) · Elsevier eBooks · doi:10.1016/b978-0-12-474980-1.50022-2 · Cited by 110 · see citing works
Perlow, M. J., Reppert, S. M., Artman, H. A., Fisher, D. A., Self, S. M., & Robinson, A. G. (1982) · Science · doi:10.1126/science.7201163 · Cited by 105 · see citing works
Shapiro, L. E., & Dewsbury, D. A. (1990) · Journal of comparative psychology · doi:10.1037/0735-7036.104.3.268 · Cited by 95 · see citing works
Oxytocin Receptor Binding in Female Prairie Voles: Endogenous and Exogenous Oestradiol Stimulation
Witt, D. M., Carter, C. S., & Lnsel, T. R. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00258.x · Cited by 91 · see citing works
Johnson, A. E., Ball, G. F., Coirini, H., Harbaugh, C. R., McEwen, B. S., & Insel, T. R. (1989) · Endocrinology · doi:10.1210/endo-125-3-1414 · Cited by 87 · see citing works
Self-citationOxytocin and complex social behavior: species comparisons.
Winslow, J. T., Shapiro, L., Carter, C. S., & Insel, T. R. (1993) · PubMed · Cited by 80 · see citing works
Self-citationJOHNSON, A. E., COIRINI, H., INSEL, T. R., & McEWEN, B. S. (1991) · Endocrinology · doi:10.1210/endo-128-2-891 · Cited by 71 · see citing works
Hnatczuk, O. C., Lisciotto, C. A., DonCarlos, L. L., Carter, C. S., & Morrell, J. I. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00558.x · Cited by 56 · see citing works
Witt, D. M., Carter, C. S., Carlstead, K., & Read, L. D. (1988) · Animal Behaviour · doi:10.1016/s0003-3472(88)80217-3 · Cited by 54 · see citing works
Simmons, C. F., Clancy, T. E., Quan, R., & Knoll, J. H. M. (1995) · Genomics · doi:10.1016/0888-7543(95)80188-r · Cited by 42 · see citing works
Wang (1996) · doi:10.1002/(sici)1096-9861(19960318)366:4
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Neuroendocrine perspectives on social attachment and love
Sue Carter, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00055-9 · Cited by 1,425 · see citing works
depue, R. A., & morrone-strupinsky, J. V. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000063 · Cited by 958 · see citing works
Graustella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.002 · Cited by 379 · see citing works
Schneiderman, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.021 · Cited by 317 · see citing works
“OT is a nonapeptide hormone associated with affiliative bonding in mammals (Insel et al., 1997) that is known to mediate social behavior, pair-bonding, and parental attachment across a variety of species (Carter, 1998).”
Feldman, R., Weller, A., Leckman, J. F., Kuint, J., & Eidelman, A. I. (1999) · Journal of Child Psychology and Psychiatry · doi:10.1017/s0021963099004308 · Cited by 317 · see citing works
Romantic love and sexual desire in close relationships
Gonzaga, G. C., Turner, R. A., Keltner, D., Campos, B., & Altemus, M. (2006) · Emotion · doi:10.1037/1528-3542.6.2.163 · Cited by 292 · see citing works
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162 · see citing works
Ismail, N., Gelez, H., Lachapelle, I., & Pfaus, J. G. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.09.013 · Cited by 38 · see citing works
Oxytocin receptors in non-human primate brain visualized with monoclonal antibody
Boccia, M. L., Panicker, A. K., Pedersen, C., & Petrusz, P. (2001) · Neuroreport · doi:10.1097/00001756-200106130-00041 · Cited by 21 · see citing works
- Authors
- INSEL, T. R., YOUNG, L., & WANG, Z.
- Affiliations
- Emory University (US)
- Corresponding author
- INSEL, THOMAS R.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1997-01
- Volume
- 807
- Issue
- 1
- Pages
- 302-316
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2000118536
- Cited by
- 56
- References
- 36
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2014: 1 · 2013: 2 · 2012: 6
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- monogamy, oxytocin receptor, Microtus ochrogaster, montane vole, pair bonding, species differences, regulatory elements, voles, microtines, vasopressin, social behavior genetics
- MeSH terms
- Animals, Base Sequence, Brain, Arvicolinae, Female, Humans, Male, Maternal Behavior, Molecular Sequence Data, Object Attachment, Oxytocin, Paternal Behavior, Sequence Homology, Nucleic Acid, Sexual Behavior, Animal, Social Behavior, Species Specificity, Receptors, Oxytocin, Rats
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