Nicotine infusion into rat ventromedial nuclei and effects on monoaminergic system
Abstract
Nicotine increases satiety and reduces food intake (FI). We hypothesize that nicotine influences FI via alteration of serotonin (5HT) and dopamine (DA) concentration in ventromedial nucleus (VMN) and lateral hypothalamic area (LHA). Microdialysis cannulas were implanted into ipsilateral VMN and contralateral LHA. Nicotine or vehicle was infused for 60 min into VMN of overnight food-deprived rats, followed by ad lib food for 40 min. Hypothalamic changes in 5HT and DA concentrations were measured every 20 min. Intra-VMN nicotine induced a long-lasting increase in 5HT concentration and an increase in DA for a short duration in the VMN, associated with an increase in 5HT in the LHA. Our data suggest that the nicotine-induced hypophagia correlates with VMN and LHA monoaminergic changes.
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Nicotine, signaling through nAChRs, can influence serotonergic transmission in a complex manner, generally acting to increase serotonin release in many brain regions, including the hypothalamus.
“Nicotine, signaling through nAChRs, can influence serotonergic transmission in a complex manner, generally acting to increase serotonin release in many brain regions (reviewed in Seth et al., 2002), including the hypothalamus (Ramos et al., 2004).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Ramos et al., 2004
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Picciotto, M. R., Lewis, A. S., van Schalkwyk, G. I., & Mineur, Y. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.028 · Cited by 157 · see citing works
- Authors
- Ramos, E. J. B., Meguid, M. M., Zhang, L., Miyata, G., Fetissov, S. O., Chen, C., Suzuki, S., & Laviano, A.
- Affiliations
- SUNY Upstate Medical University (US)
- Venue
- Neuroreport
- Published
- 2004-10
- Volume
- 15
- Issue
- 14
- Pages
- 2293-2297
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1975680543
- Cited by
- 16
- References
- 22
- Citations by year
- 2025: 1 · 2018: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- U.S. Public Health Service (003568)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, ventromedial hypothalamus, lateral hypothalamus, serotonin, dopamine, dietary intake, satiety, hypophagia, monoaminergic systems, hypothalamus, food deprivation
- MeSH terms
- Animals, Dopamine, Injections, Intraventricular, Male, Nicotine, Rats, Inbred F344, Serotonin, Ventromedial Hypothalamic Nucleus, Biogenic Monoamines, Rats
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