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Cited by 323Regulation of Appetite and ObesityNicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Nicotinic receptor‐mediated effects on appetite and food intake

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Jo, Young‐Hwan, Talmage, David A., Role, Lorna W.·2002·Journal of Neurobiology
DOI 10.1002/neu.10147PMC PMC2367209
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Abstract

It is well known, although not well understood, that smoking and eating just do not go together. Smoking is associated with decreased food intake and lower body weight. Nicotine, administered either by smoking or by smokeless routes, is considered the major appetite‐suppressing component of tobacco. Perhaps the most renowned example of nicotine's influence on appetite and feeding behavior is the significant weight gain associated with smoking cessation. This article presents an overview of the literature at, or near, the interface of nicotinic receptors and appetite regulation. We first consider some of the possible sites of nicotine's action along the complex network of neural and non‐neural regulators of feeding. We then present the hypothesis that the lateral hypothalamus is a particularly important locus of the anorectic effects of nicotine. Finally, we discuss the potential role of endogenous cholinergic systems in motivational feeding, focusing on cholinergic pathways in the lateral hypothalamus. © 2002 Wiley Periodicals, Inc. J Neurobiol 53: 618–632, 2002

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  • Smoking significantly influences eating behavior through physiological mechanisms primarily mediated by nicotine, including appetite suppression, altered metabolism and energy balance, and effects on hunger-related hormones such as ghrelin and leptin.

    “Smoking significantly influences eating behavior through various physiological mechanisms, primarily mediated by nicotine. These mechanisms include appetite suppression, alteration in metabolism and energy balance and impact on hunger-related hormones such as ghrelin and lepton [2, 9].”

    From Smoking and its impact on eating behavior: A review (2026) · cites this paper as [9]

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  • Nicotine stimulates the hypothalamic melanocortin system, and its interaction with melanocortin-4 receptors contributes to appetite suppression, decreasing appetite and increasing metabolism.

    “Nicotine also stimulates the hypothalamic melanocortin system, which plays a crucial role in regulating feeding behavior and energy homeostasis. This activation leads to reduced food intake and consequently, weight loss [5]. Further, studies suggest that nicotine's interaction with the central melanocortin system, particularly the melanocortin-4 receptors, also contributes to appetite suppression.”

    From Smoking and its impact on eating behavior: A review (2026) · cites this paper as [9]

    The Introduction reports that nicotine suppresses food intake and discusses the lateral hypothalamus as a possible site of action. It separately explains that MC4 receptor signaling normally limits food intake and body fat, but does not show that nicotine stimulates the melanocortin system or acts through MC4 receptors. It also says findings on nicotine-induced changes in overall metabolic rate are variable, rather than establishing increased metabolism. (LLM, conf=0.88)

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References 143 · Cited by 323

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  1. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382:250–252. doi: 10.1038/382250a0. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  2. Albanes D, Jones DY, Micozzi MS, Mattson ME. Associations between smoking and body weight in the US population: analysis of NHANES II. Am J Public Health. 1987;77:439–444. doi: 10.2105/ajph.77.4.439. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  3. Arai K, Kim K, Kaneko K, Iketani M, Otagiri A, Yamauchi N, Shibasaki T. Nicotine infusion alters leptin and un-coupling protein 1 mRNA expression in adipose tissues of rats. Am J Physiol Endocrinol Metab. 2001;280:E867–E876. doi: 10.1152/ajpendo.2001.280.6.E867. [DOI] [PubMed] [Google Scholar] · DOI
  4. Ashakumary L, Vijayammal PL. Effect of nicotine on lipoprotein metabolism in rats. Lipids. 1997;32:311–315. doi: 10.1007/s11745-997-0038-8. [DOI] [PubMed] [Google Scholar] · DOI
  5. Bayer L, Risold PY, Griffond B, Fellmann D. Rat diencephalic neurons producing melanin-concentrating hormone are influenced by ascending cholinergic projections. Neuroscience. 1999;91:1087–1101. doi: 10.1016/s0306-4522(98)00678-2. [DOI] [PubMed] [Google Scholar] · DOI
  6. Bittencourt JC, Elias CF. Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers. Brain Res. 1998;805:1–19. doi: 10.1016/s0006-8993(98)00598-8. [DOI] [PubMed] [Google Scholar] · DOI
  7. Blaha V, Yang ZJ, Meguid M, Chai JK, Zadak Z. Systemic nicotine administration suppresses food intake via reduced meal sizes in both male and female rats. Acta Med. 1998;41:167–173. [PubMed] [Google Scholar]
  8. Bray GA. Reciprocal relation of food intake and sympathetic activity: experimental observations and clinical implications. Int J Obes Relat Metab Disord. 2000;24(Suppl 2):S8–S17. doi: 10.1038/sj.ijo.0801269. [DOI] [PubMed] [Google Scholar] · DOI
  9. Britto LR, Keyser KT, Lindstrom JM, Karten HJ. Immunohistochemical localization of nicotinic acetylcholine receptor subunits in the mesencephalon and diencephalon of the chick (Gallus gallus) J Comp Neurol. 1992;317:325–340. doi: 10.1002/cne.903170402. [DOI] [PubMed] [Google Scholar] · DOI
  10. Broberger C, De Lecea L, Sutcliffe JG, Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol. 1998;402:460–474. [PubMed] [Google Scholar]
  11. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546–549. doi: 10.1126/science.7624778. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  12. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Goldman WH, Lynn RB, Zhang PL, Sinha MK, Considine RV. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 1996;348:159–161. doi: 10.1016/s0140-6736(96)03173-x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  13. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98:437–451. doi: 10.1016/s0092-8674(00)81973-x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  14. Chiesi M, Huppertz C, Hofbauer KG. Pharmacotherapy of obesity: targets and perspectives. Trends Pharmacol Sci. 2001;22:247–254. doi: 10.1016/s0165-6147(00)01664-3. [DOI] [PubMed] [Google Scholar] · DOI
  15. Conroy WG, Berg DK. Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit compositions. J Biol Chem. 1995;270:4424–4431. doi: 10.1074/jbc.270.9.4424. [DOI] [PubMed] [Google Scholar] · DOI
  16. Cooper E. Nicotinic acetylcholine receptors on vagal afferent neurons. Ann N Y Acad Sci. 2001;940:110–118. doi: 10.1111/j.1749-6632.2001.tb03670.x. [DOI] [PubMed] [Google Scholar] · DOI
  17. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411:480–484. doi: 10.1038/35078085. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  18. Dani JA. Overview of nicotinic receptors and their roles in the central nervous system. Biol Psychiatry. 2001;49:166–174. doi: 10.1016/s0006-3223(00)01011-8. [DOI] [PubMed] [Google Scholar] · DOI
  19. Davila-Garcia MI, Houghtling RA, Qasba SS, Kellar KJ. Nicotinic receptor binding sites in rat primary neuronal cells in culture: characterization and their regulation by chronic nicotine. Brain Res Mol Brain Res. 1999;66:14–23. doi: 10.1016/s0169-328x(98)00344-1. [DOI] [PubMed] [Google Scholar] · DOI
  20. De Biasi M, Nigro F, Xu W. Nicotinic acetylcholine receptors in the autonomic control of bladder function. Eur J Pharmacol. 2000;393:137–140. doi: 10.1016/s0014-2999(00)00008-x. [DOI] [PubMed] [Google Scholar] · DOI
  21. Donahue RP, Zimmet P, Bean JA, Decourten M, DeCarlo Donahue RA, Collier G, Goldberg RB, Prineas RJ, Skyler J, Schneiderman N. Cigarette smoking, alcohol use, and physical activity in relation to serum leptin levels in a multiethnic population: The Miami Community Health Study. Ann Epidemiol. 1999;9:108–113. doi: 10.1016/s1047-2797(98)00037-4. [DOI] [PubMed] [Google Scholar] · DOI
  22. Du C, Role LW. Differential modulation of nicotinic acetylcholine receptor subtypes and synaptic transmission in chick sympathetic ganglia by PGE(2) J Neurophysiol. 2001;85:2498–2508. doi: 10.1152/jn.2001.85.6.2498. [DOI] [PubMed] [Google Scholar] · DOI
  23. Ehlert FJ, Tran LP. Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain. J Pharmacol Exp Ther. 1990;255:1148–1157. [PubMed] [Google Scholar]
  24. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 1999;23:775–786. doi: 10.1016/s0896-6273(01)80035-0. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  25. Elias CF, Kelly JF, Lee CE, Ahima RS, Drucker DJ, Saper CB, Elmquist JK. Chemical characterization of leptin-activated neurons in the rat brain. J Comp Neurol. 2000;423:261–281. [PubMed] [Google Scholar]
  26. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron. 1998;21:1375–1385. doi: 10.1016/s0896-6273(00)80656-x. [DOI] [PubMed] [Google Scholar] · DOI
  27. Elias CF, Lee CE, Kelly JF, Ahima RS, Kuhar M, Saper CB, Elmquist JK. Characterization of CART neurons in the rat and human hypothalamus. J Comp Neurol. 2001;432:1–19. doi: 10.1002/cne.1085. [DOI] [PubMed] [Google Scholar] · DOI
  28. Eliasson B, Smith U. Leptin levels in smokers and long-term users of nicotine gum. Eur J Clin Invest. 1999;29:145–152. doi: 10.1046/j.1365-2362.1999.00420.x. [DOI] [PubMed] [Google Scholar] · DOI
  29. Elmquist JK. Hypothalamic pathways underlying the endocrine, autonomic and behavioral effects of leptin. Int J Obes Relat Metab Disord. 2001;25:S78–S82. doi: 10.1038/sj.ijo.0801918. [DOI] [PubMed] [Google Scholar] · DOI
  30. Elmquist JK, Elias CF, Saper CB. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 1999;22:221–232. doi: 10.1016/s0896-6273(00)81084-3. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  31. Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science. 1996;274:1704–1707. doi: 10.1126/science.274.5293.1704. [DOI] [PubMed] [Google Scholar] · DOI
  32. Fadel J, Deutch AY. Anatomical substrates of orexindopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience. 2002;111:379–387. doi: 10.1016/s0306-4522(02)00017-9. [DOI] [PubMed] [Google Scholar] · DOI
  33. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 1997;385:165–168. doi: 10.1038/385165a0. [DOI] [PubMed] [Google Scholar] · DOI
  34. Flier JS, Maratos-Flier E. Obesity and the hypothalamus: novel peptides for new pathways. Cell. 1998;92:437–440. doi: 10.1016/s0092-8674(00)80937-x. [DOI] [PubMed] [Google Scholar] · DOI
  35. Frankish HM, Dryden S, Wang Q, Bing C, MacFarlane IA, Williams G. Nicotine administration reduces neuropeptide Y and neuropeptide Y mRNA concentrations in the rat hypothalamus: NPY may mediate nicotine's effects on energy balance. Brain Res. 1995;694:139–146. doi: 10.1016/0006-8993(95)00834-d. [DOI] [PubMed] [Google Scholar] · DOI
  36. Gao XB, van den Pol AN. Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J Physiol. 2001;533:237–252. doi: 10.1111/j.1469-7793.2001.0237b.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  37. Gotti C, Fornasari D, Clementi F. Human neuronal nicotinic receptors. Prog Neurobiol. 1997;53:199–237. doi: 10.1016/s0301-0082(97)00034-8. [DOI] [PubMed] [Google Scholar] · DOI
  38. Grunberg NE. Nicotine as a psychoactive drug: appetite regulation. Psychopharmacol Bull. 1986;22:875–881. [PubMed] [Google Scholar]
  39. Grunberg NE, Bowen DJ, Winders SE. Effects of nicotine on body weight and food consumption in female rats. Psychopharmacology (Berlin) 1986;90:101–105. doi: 10.1007/BF00172879. [DOI] [PubMed] [Google Scholar] · DOI
  40. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543–546. doi: 10.1126/science.7624777. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  41. Hara, Beuckmann Ct, Nambu, Willie Jt, Chemelli Rm, Sinton Cm, Sugiyama, Yagami, Goto, Yanagisawa, Sakurai Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron. 2001;30:345–354. doi: 10.1016/s0896-6273(01)00293-8. [DOI] [PubMed] [Google Scholar] · DOI
  42. Harfstrand A, Adem A, Fuxe K, Agnati L, Andersson K, Nordberg A. Distribution of nicotinic cholinergic receptors in the rat tel- and diencephalon: a quantitative receptor autoradiographical study using [3H]-acetylcholine, [alpha-125I]bungarotoxin and [3H]nicotine. Acta Physiol Scand. 1988;132:1–14. doi: 10.1111/j.1748-1716.1988.tb08291.x. [DOI] [PubMed] [Google Scholar] · DOI
  43. Harvey J, McKenna F, Herson PS, Spanswick D, Ashford ML. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J Physiol. 1997;504(Pt 3):527–535. doi: 10.1111/j.1469-7793.1997.527bd.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  44. Hatton GI, Yang QZ. Synaptic potentials mediated by alpha 7 nicotinic acetylcholine receptors in supraoptic nucleus. J Neurosci. 2002;22:29–37. doi: 10.1523/JNEUROSCI.22-01-00029.2002. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  45. Hodge AM, Westerman RA, de Courten MP, Collier GR, Zimmet PZ, Alberti KG. Is leptin sensitivity the link between smoking cessation and weight gain? Int J Obes Relat Metab Disord. 1997;21:50–53. doi: 10.1038/sj.ijo.0800362. [DOI] [PubMed] [Google Scholar] · DOI
  46. Horvath TL, Diano S, van den Pol AN. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci. 1999;19:1072–1087. doi: 10.1523/JNEUROSCI.19-03-01072.1999. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  47. Hungs M, Mignot E. Hypocretin/orexin, sleep and narcolepsy. Bioessays. 2001;23:397–408. doi: 10.1002/bies.1058. [DOI] [PubMed] [Google Scholar] · DOI
  48. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997;88:131–141. doi: 10.1016/s0092-8674(00)81865-6. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  49. Jacob RJ, Dziura J, Medwick MB, Leone P, Caprio S, During M, Shulman GI, Sherwin RS. The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus. Diabetes. 1997;46:150–152. doi: 10.2337/diab.46.1.150. [DOI] [PubMed] [Google Scholar] · DOI
  50. Jo YH, Role LW. Coordinate release of ATP and GABA at in vitro synapses of lateral hypothalamic neurons. J. Neurosci. 2002a;22:4794–4804. doi: 10.1523/JNEUROSCI.22-12-04794.2002. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  51. Jo YH, Role LW. Differential modulation of synaptic transmission by nicotinic and muscarinic-receptor mediated pathways in lateral hypothalamus. J Neurophysiol. 2002b [Google Scholar]
  52. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev. 1999;20:68–100. doi: 10.1210/edrv.20.1.0357. [DOI] [PubMed] [Google Scholar] · DOI
  53. Kane JK, Parker SL, Li MD. Hypothalamic orexin-A binding sites are downregulated by chronic nicotine treatment in the rat. Neurosci Lett. 2001;298:1–4. doi: 10.1016/s0304-3940(00)01730-4. [DOI] [PubMed] [Google Scholar] · DOI
  54. Kane JK, Parker SL, Matta SG, Fu Y, Sharp BM, Li MD. Nicotine up-regulates expression of orexin and its receptors in rat brain. Endocrinology. 2000;141:3623–3629. doi: 10.1210/endo.141.10.7707. [DOI] [PubMed] [Google Scholar] · DOI
  55. Klesges RC, Meyers AW, Klesges LM, La Vasque ME. Smoking, body weight, and their effects on smoking behavior: a comprehensive review of the literature. Psychol Bull. 1989;106:204–230. doi: 10.1037/0033-2909.106.2.204. [DOI] [PubMed] [Google Scholar] · DOI
  56. Kotz CM, Teske JA, Levine JA, Wang C. Feeding and activity induced by orexin A in the lateral hypothalamus in rats. Regul Pept. 2002;104:27–32. doi: 10.1016/s0167-0115(01)00346-9. [DOI] [PubMed] [Google Scholar] · DOI
  57. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998;393:72–76. doi: 10.1038/29993. [DOI] [PubMed] [Google Scholar] · DOI
  58. Krisufek D, Stocker E, Boehm S, Huck S. Somatic and prejunctional nicotinic receptors in cultured rat sympathetic neurons show different agonist profiles. J Physiol. 1999;516(Pt 3):739–756. doi: 10.1111/j.1469-7793.1999.0739u.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  59. Lambert PD, Couceyro PR, McGirr KM, Dall Vechia SE, Smith Y, Kuhar MJ. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse. 1998;29:293–298. doi: 10.1002/(SICI)1098-2396(199808)29:4<293::AID-SYN1>3.0.CO;2-0. [DOI] [PubMed] [Google Scholar] · DOI
  60. Lantos TA, Gorcs TJ, Palkovits M. Immunohistochemical mapping of neuropeptides in the premamillary region of the hypothalamus in rats. Brain Res Brain Res Rev. 1995;20:209–249. doi: 10.1016/0165-0173(94)00013-f. [DOI] [PubMed] [Google Scholar] · DOI
  61. Lawrence CB, Turnbull AV, Rothwell NJ. Hypothalamic control of feeding. Curr Opin Neurobiol. 1999;9:778–783. doi: 10.1016/s0959-4388(99)00032-x. [DOI] [PubMed] [Google Scholar] · DOI
  62. Leonard S, Bertrand D. Neuronal nicotinic receptors: from structure to function. Nicotine Tob Res. 2001;3:203–223. doi: 10.1080/14622200110050213. [DOI] [PubMed] [Google Scholar] · DOI
  63. Levin ED, Morgan MM, Galvez C, Ellison GD. Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats. Physiol Behav. 1987;39:441–444. doi: 10.1016/0031-9384(87)90370-2. [DOI] [PubMed] [Google Scholar] · DOI
  64. Li DP, Pan HL. Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors. Am J Physiol Regul Integr Comp Physiol. 2001;281:R1105–R1113. doi: 10.1152/ajpregu.2001.281.4.R1105. [DOI] [PubMed] [Google Scholar] · DOI
  65. Li DP, Pan YZ, Pan HL. Acetylcholine attenuates synaptic GABA release to supraoptic neurons through presynaptic nicotinic receptors. Brain Res. 2001;920:151–158. doi: 10.1016/s0006-8993(01)03055-4. [DOI] [PubMed] [Google Scholar] · DOI
  66. Li MD, Kane JK, Parker SL, McAllen K, Matta SG, Sharp BM. Nicotine administration enhances NPY expression in the rat hypothalamus. Brain Res. 2000a;867:157–164. doi: 10.1016/s0006-8993(00)02283-6. [DOI] [PubMed] [Google Scholar] · DOI
  67. Li MD, Parker SL, Kane JK. Regulation of feeding-associated peptides and receptors by nicotine. Mol Neurobiol. 2000b;22:143–165. doi: 10.1385/MN:22:1-3:143. [DOI] [PubMed] [Google Scholar] · DOI
  68. Liu M, Seino S, Kirchgessner AL. Identification and characterization of glucoresponsive neurons in the enteric nervous system. J Neurosci. 1999;19:10305–10317. doi: 10.1523/JNEUROSCI.19-23-10305.1999. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  69. Marin P, Hamon B, Glowinski J, Premont J. Nicotine-induced inhibition of neuronal phospholipase A2. J Pharmacol Exp Ther. 1997;280:1277–1283. [PubMed] [Google Scholar]
  70. Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, Guan XM, Jiang MM, Feng Y, Camacho RE, Shen Z, Frazier EG, Yu H, Metzger JM, Kuca SJ, Shearman LP, Gopal-Truter S, MacNeil DJ, Strack AM, MacIntyre DE, Van der Ploeg LH, Qian S. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci USA. 2002;99:3240–3245. doi: 10.1073/pnas.052706899. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  71. McGehee DS. Molecular diversity of neuronal nicotinic acetylcholine receptors. Ann NY Acad Sci. 1999;868:565–577. doi: 10.1111/j.1749-6632.1999.tb11330.x. [DOI] [PubMed] [Google Scholar] · DOI
  72. McGehee DS, Heath MJ, Gelber S, Devay P, Role LW. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science. 1995;269:1692–1696. doi: 10.1126/science.7569895. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  73. Meguid MM, Fetissov SO, Varma M, Sato T, Zhang L, Laviano A, Rossi-Fanelli F. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition. 2000;16:843–857. doi: 10.1016/s0899-9007(00)00449-4. [DOI] [PubMed] [Google Scholar] · DOI
  74. Merchenthaler I, Lopez FJ, Negro-Vilar A. Anatomy and physiology of central galanin-containing pathways. Prog Neurobiol. 1993;40:711–769. doi: 10.1016/0301-0082(93)90012-h. [DOI] [PubMed] [Google Scholar] · DOI
  75. Miyata G, Meguid MM, Fetissov SO, Torelli GF, Kim HJ. Nicotine's effect on hypothalamic neurotransmitters and appetite regulation. Surgery. 1999;126:255–263. [PubMed] [Google Scholar]
  76. Miyata G, Meguid MM, Varma M, Fetissov SO, Kim HJ. Nicotine alters the usual reciprocity between meal size and meal number in female rat. Physiol Behav. 2001;74:169–176. doi: 10.1016/s0031-9384(01)00540-6. [DOI] [PubMed] [Google Scholar] · DOI
  77. Neal CR, Jr, Newman SW. Prodynorphin peptide distribution in the forebrain of the Syrian hamster and rat: a comparative study with antisera against dynorphin A, dynorphin B, and the C-terminus of the prodynorphin precursor molecule. J Comp Neurol. 1989;288:353–386. doi: 10.1002/cne.902880302. [DOI] [PubMed] [Google Scholar] · DOI
  78. Nicklas BJ, Tomoyasu N, Muir J, Goldberg AP. Effects of cigarette smoking and its cessation on body weight and plasma leptin levels. Metabolism. 1999;48:804–808. doi: 10.1016/s0026-0495(99)90183-x. [DOI] [PubMed] [Google Scholar] · DOI
  79. Niijima A. Afferent signals from leptin sensors in the white adipose tissue of the epididymis, and their reflex effect in the rat. J Auton Nerv Syst. 1998;73:19–25. doi: 10.1016/s0165-1838(98)00109-x. [DOI] [PubMed] [Google Scholar] · DOI
  80. Nonogaki K, Strack AM, Dallman MF, Tecott LH. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med. 1998;4:1152–1156. doi: 10.1038/2647. [DOI] [PubMed] [Google Scholar] · DOI
  81. Nordstrom BL, Kinnunen T, Utman CH, Garvey AJ. Long-term effects of nicotine gum on weight gain after smoking cessation. Nicotine Tob Res. 1999;1:259–268. doi: 10.1080/14622299050011381. [DOI] [PubMed] [Google Scholar] · DOI
  82. O'Hara BF, Edgar DM, Cao VH, Wiler SW, Heller HC, Kilduff TS, Miller JD. Nicotine and nicotinic receptors in the circadian system. Psychoneuroendocrinology. 1998;23:161–173. doi: 10.1016/s0306-4530(97)00077-2. [DOI] [PubMed] [Google Scholar] · DOI
  83. Okuda H, Shioda S, Nakai Y, Nakayama H, Okamoto M, Nakashima T. Immunocytochemical localization of nicotinic acetylcholine receptor in rat hypothalamus. Brain Res. 1993;625:145–151. doi: 10.1016/0006-8993(93)90147-f. [DOI] [PubMed] [Google Scholar] · DOI
  84. Pabreza LA, Dhawan S, Kellar KJ. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991;39:9–12. [PubMed] [Google Scholar]
  85. Pajolla GP, Crippa GE, Correa SA, Moreira KB, Tavares RF, Correa FM. The lateral hypothalamus is involved in the pathway mediating the hypotensive response to cingulate cortex-cholinergic stimulation. Cell Mol Neurobiol. 2001;21:341–356. doi: 10.1023/A:1012650021137. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  86. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540–543. doi: 10.1126/science.7624776. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  87. Pomerleau CS. Issues for women who wish to stop smoking. In: Seidman DF, Covey LS, editors. Helping the hard-core smoker. Lawrence Erlbaum; London: 1999. pp. 73–91. 1999. [Google Scholar]
  88. Pomerleau CS, Pomerleau OF, Namenek RJ, Mehringer AM. Short-term weight gain in abstaining women smokers. J Subst Abuse Treat. 2000;18:339–342. doi: 10.1016/s0740-5472(99)00085-9. [DOI] [PubMed] [Google Scholar] · DOI
  89. Pu S, Jain MR, Horvath TL, Diano S, Kalra PS, Kalra SP. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology. 1999;140:933–940. doi: 10.1210/endo.140.2.6495. [DOI] [PubMed] [Google Scholar] · DOI
  90. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 1996;380:243–247. doi: 10.1038/380243a0. [DOI] [PubMed] [Google Scholar] · DOI
  91. Risold PY, Fellmann D, Lenys D, Bugnon C. Coexistence of acetylcholinesterase-, human growth hormone-releasing factor(1–37)-, alpha-melanotropin- and melanin-concentrating hormone-like immunoreactivities in neurons of the rat hypothalamus: a light and electron microscope study. Neurosci Lett. 1989;100:23–28. doi: 10.1016/0304-3940(89)90654-x. [DOI] [PubMed] [Google Scholar] · DOI
  92. Roth AL, Shoop RD, Berg DK. Targeting alpha7-containing nicotinic receptors on neurons to distal locations. Eur J Pharmacol. 2000;393:105–112. doi: 10.1016/s0014-2999(00)00092-3. [DOI] [PubMed] [Google Scholar] · DOI
  93. Rust G, Burgunder JM, Lauterburg TE, Cachelin AB. Expression of neuronal nicotinic acetylcholine receptor subunit genes in the rat autonomic nervous system. Eur J Neurosci. 1994;6:478–485. doi: 10.1111/j.1460-9568.1994.tb00290.x. [DOI] [PubMed] [Google Scholar] · DOI
  94. Sakurai T. Orexins and orexin receptors: implication in feeding behavior. Regul Pept. 1999;85:25–30. doi: 10.1016/s0167-0115(99)00076-2. [DOI] [PubMed] [Google Scholar] · DOI
  95. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92:573–585. doi: 10.1016/s0092-8674(00)80949-6. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  96. Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001;24:726–731. doi: 10.1016/s0166-2236(00)02002-6. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  97. Schafer MK, Eiden LE, Weihe E. Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. I. Central nervous system. Neuroscience. 1998;84:331–359. doi: 10.1016/s0306-4522(97)00516-2. [DOI] [PubMed] [Google Scholar] · DOI
  98. Schick RR, Samsami S, Zimmermann JP, Eberl T, Endres C, Schusdziarra V, Classen M. Effect of galanin on food intake in rats: involvement of lateral and ventromedial hypothalamic sites. Am J Physiol. 1993;264:R355–R361. doi: 10.1152/ajpregu.1993.264.2.R355. [DOI] [PubMed] [Google Scholar] · DOI
  99. Schwartz DH, McClane S, Hernandez L, Hoebel BG. Feeding increases extracellular serotonin in the lateral hypothalamus of the rat as measured by microdialysis. Brain Res. 1989;479:349–354. doi: 10.1016/0006-8993(89)91639-9. [DOI] [PubMed] [Google Scholar] · DOI
  100. Schwartz MW, Woods SC, Porte D, Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404:661–671. doi: 10.1038/35007534. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  101. Schwartz RD, Lehmann J, Kellar KJ. Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. J Neurochem. 1984;42:1495–1498. doi: 10.1111/j.1471-4159.1984.tb02818.x. [DOI] [PubMed] [Google Scholar] · DOI
  102. Sha L, Szurszewski JH. Leptin modulates fast synaptic transmission in dog pancreatic ganglia. Neurosci Lett. 1999;263:93–96. doi: 10.1016/s0304-3940(99)00122-6. [DOI] [PubMed] [Google Scholar] · DOI
  103. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998;396:670–674. doi: 10.1038/25341. [DOI] [PubMed] [Google Scholar] · DOI
  104. Shioda S, Nakajo S, Hirabayashi T, Nakayama H, Nakaya K, Matsuda K, Nakai Y. Neuronal nicotinic acetylcholine receptor in the hypothalamus: morphological diversity and neuroendocrine regulations. Brain Res Mol Brain Res. 1997;49:45–54. doi: 10.1016/s0169-328x(97)00122-8. [DOI] [PubMed] [Google Scholar] · DOI
  105. Shiraishi T, Oomura Y, Sasaki K, Wayner MJ. Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons. Physiol Behav. 2000;71:251–261. doi: 10.1016/s0031-9384(00)00341-3. [DOI] [PubMed] [Google Scholar] · DOI
  106. Shoop RD, Chang KT, Ellisman MH, Berg DK. Synaptically driven calcium transients via nicotinic receptors on somatic spines. J Neurosci. 2001;21:771–781. doi: 10.1523/JNEUROSCI.21-03-00771.2001. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  107. Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford ML. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 1997;390:521–525. doi: 10.1038/37379. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  108. Speigelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001;104:531–543. doi: 10.1016/s0092-8674(01)00240-9. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  109. Stamford BA, Matter S, Fell RD, Papanek P. Effects of smoking cessation on weight gain, metabolic rate, caloric consumption, and blood lipids. Am J Clin Nutr. 1986;43:486–494. doi: 10.1093/ajcn/43.4.486. [DOI] [PubMed] [Google Scholar] · DOI
  110. Stanley BG, Chin AS, Leibowitz SF. Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action. Brain Res Bull. 1985;14:521–524. doi: 10.1016/0361-9230(85)90100-5. [DOI] [PubMed] [Google Scholar] · DOI
  111. Stella N, Piomelli D. Receptor-dependent formation of endogenous cannabinoids in cortical neurons. Eur J Pharmacol. 2001;425:189–196. doi: 10.1016/s0014-2999(01)01182-7. [DOI] [PubMed] [Google Scholar] · DOI
  112. Stratford TR, Kelley AE. Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. J Neurosci. 1999;19:11040–11048. doi: 10.1523/JNEUROSCI.19-24-11040.1999. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  113. Sutcliffe JG, De Lecea L. The hypocretins: setting the arousal threshold. Nat Rev Neurosci. 2002;3:339–349. doi: 10.1038/nrn808. [DOI] [PubMed] [Google Scholar] · DOI
  114. Szczypka MS, Rainey MA, Kim DS, Alaynick WA, Marck BT, Matsumoto AM, Palmiter RD. Feeding behavior in dopamine-deficient mice. Proc Natl Acad Sci USA. 1999;96:12138–12143. doi: 10.1073/pnas.96.21.12138. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  115. Szczypka MS, Rainey MA, Palmiter RD. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet. 2000;25:102–104. doi: 10.1038/75484. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  116. Sztalryd C, Hamilton J, Horowitz BA, Johnson P, Kraemer FB. Alterations of lipolysis and lipoprotein lipase in chronically nicotine-treated rats. Am J Physiol. 1996;270:E215–E223. doi: 10.1152/ajpendo.1996.270.2.E215. [DOI] [PubMed] [Google Scholar] · DOI
  117. Tago H, McGeer PL, Bruce G, Hersh LB. Distribution of choline acetyltransferase-containing neurons of the hypothalamus. Brain Res. 1987;415:49–62. doi: 10.1016/0006-8993(87)90268-x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  118. Tartaglia LA. The leptin receptor. J Biol Chem. 1997;272:6093–6096. doi: 10.1074/jbc.272.10.6093. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  119. Temburni MK, Blitzblau RC, Jacob MH. Receptor targeting and heterogeneity at interneuronal nicotinic cholinergic synapses in vivo. J Physiol. 2000;525(Pt 1):21–29. doi: 10.1111/j.1469-7793.2000.00021.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  120. Tieman TL, Steel DJ, Gor Y, Kehoe J, Schwartz JH, Feinmark SJ. A pertussis toxin-sensitive 8-lipoxygenase pathway is activated by a nicotinic acetylcholine receptor in Aplysia neurons. J Neurophysiol. 2001;85:2150–2158. doi: 10.1152/jn.2001.85.5.2150. [DOI] [PubMed] [Google Scholar] · DOI
  121. Tribollet E, Bertrand D, Raggenbass M. Role of neuronal nicotinic receptors in the transmission and processing of information in neurons of the central nervous system. Pharmacol Biochem Behav. 2001;70:457–466. doi: 10.1016/s0091-3057(01)00700-6. [DOI] [PubMed] [Google Scholar] · DOI
  122. Vijayaraghavan S, Huang B, Blumenthal EM, Berg DK. Arachidonic acid as a possible negative feedback inhibitor of nicotinic acetylcholine receptors on neurons. J Neurosci. 1995;15:3679–3687. doi: 10.1523/JNEUROSCI.15-05-03679.1995. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  123. Wei J, Walton EA, Milici A, Buccafusco JJ. m1–m5 muscarinic receptor distribution in rat CNS by RT-PCR and HPLC. J Neurochem. 1994;63:815–821. doi: 10.1046/j.1471-4159.1994.63030815.x. [DOI] [PubMed] [Google Scholar] · DOI
  124. Wei M, Stern MP, Haffner SM. Serum leptin levels in Mexican Americans and non-Hispanic whites: association with body mass index and cigarette smoking. Ann Epidemiol. 1997;7:81–86. doi: 10.1016/s1047-2797(96)00114-7. [DOI] [PubMed] [Google Scholar] · DOI
  125. Willie JT, Chemelli RM, Sinton CM, Yanagisawa M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci. 2001;24:429–458. doi: 10.1146/annurev.neuro.24.1.429. [DOI] [PubMed] [Google Scholar] · DOI
  126. Woods S, Seeley C, Porte RJ, Jr, Schwartz MW. Signals that regulate food intake and energy homeostasis. Science. 1998;280:1478–1383. doi: 10.1126/science.280.5368.1378. [DOI] [PubMed] [Google Scholar] · DOI
  127. Woolf NJ. Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol. 1991;37:475–524. doi: 10.1016/0301-0082(91)90006-m. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  128. Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R, Ogawa M, Chou CJ, Xia B, Crawley JN, Felder CC, Deng CX, Wess J. Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature. 2001;410:207–212. doi: 10.1038/35065604. [DOI] [PubMed] [Google Scholar] · DOI
  129. Yang ZJ, Blaha V, Meguid MM, Oler A, Miyata G. Infusion of nicotine into the LHA enhances dopamine and 5-HT release and suppresses food intake. Pharmacol Biochem Behav. 1999;64:155–159. doi: 10.1016/s0091-3057(99)00111-2. [DOI] [PubMed] [Google Scholar] · DOI
  130. Yettefti K, Orsini JC, Perrin J. Neuronal responses to systemic nicotine in the solitary tract nucleus: origin and possible relation with nutritional effects of nicotine. Pharmacol Biochem Behav. 1997;58:529–535. doi: 10.1016/s0091-3057(97)00247-5. [DOI] [PubMed] [Google Scholar] · DOI
  131. Yoshinari M, Wakisaka M, Fujishima M. Serum leptin levels in smokers with type 2 diabetes. Diabetes Care. 1998;21:516–517. doi: 10.2337/diacare.21.4.516. [DOI] [PubMed] [Google Scholar] · DOI
  132. Zhang L, Meguid MM, Miyata G, Varma M, Fetissov SO. Role of hypothalamic monoamines in nicotine-induced anorexia in menopausal rats. Surgery. 2001;130:133–142. doi: 10.1067/msy.2001.115513. [DOI] [PubMed] [Google Scholar] · DOI

Authors
Jo, Y., Talmage, D. A., & Role, L. W.
Affiliations
  • Columbia University (US)
  • Columbia University Irving Medical Center (US)
Corresponding author
Role, Lorna W.
ORCID
Venue
Journal of Neurobiology
Publisher
Wiley
Published
2002-11-15
Volume
53
Issue
4
Pages
618-632
ISSN
  • 0022-3034 (ISSN-L)
  • 1097-4695
DOI
10.1002/neu.10147
PMC
PMC2367209
OpenAlex
W2059698784
Cited by
323
References
143
Citations by year
2026: 11 · 2025: 20 · 2024: 11 · 2023: 13 · 2022: 17 · 2021: 17 · 2020: 13 · 2019: 17 · 2018: 14 · 2017: 13 · 2016: 18 · 2015: 16 · 2014: 16 · 2013: 11 · 2012: 18
FWCI
1.10
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (CA79737, R01CA079737)
  • National Institute of Neurological Disorders and Stroke (NS29071, R01NS029071, NS22061, R01NS022061)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
nicotinic acetylcholine receptors, nicotine, appetite regulation, dietary intake, feeding behavior, smoking cessation, weight gain, lateral hypothalamus, cholinergic pathways
MeSH terms
Animals, Appetite Regulation, Eating, Humans, Hypothalamus, Nicotine, Receptors, Nicotinic, Smoking

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