Nicotine and food induced dopamine release in the nucleus accumbens of the rat: Putative role of α7 nicotinic receptors in the ventral tegmental area
Abstract
We have recently shown that the stimulatory effect of nicotine on dopamine output in the nucleus accumbens is largely dependent upon an enhanced glutamate transmission via N-methyl-D-aspartate receptors, possibly through stimulation of nicotinic receptors localized presynaptically on glutamatergic afferents in the ventral tegmental area. Given that nicotinic alpha7 receptors have been proposed to be involved in presynaptic regulation of glutamate release, we investigated whether alpha7 receptors underlie such a mechanism in the ventral tegmental area. For this purpose, by utilizing microdialysis we measured dopamine release in the nucleus accumbens in response to systemic nicotine, with, or without, concomitant infusion into the ventral tegmental area of the selective alpha7 receptor antagonist methyllycaconitine. To test also whether alpha7 nicotinic receptor antagonism within the ventral tegmental area affected a natural reward-mediated increase in dopamine release in the nucleus accumbens, we employed a model of schedule-induced feeding. Intrategmental administration of methyllycaconitine decreased both the nicotine-induced and the food-induced dopamine release in the nucleus accumbens. We suggest that alpha7 nicotinic receptors in the ventral tegmental area are involved in the acute effect of nicotine on dopamine release in the nucleus accumbens and conclude that the mechanism, by which nicotine stimulates the mesolimbic dopaminergic system, may be an essential constituen…
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Blocking α7 nicotinic AChRs in the VTA can decrease food seeking.
“blocking α7 nicotinic AChRs in the VTA can decrease food seeking (Schilström et al. 1998).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Schilström et al. 1998
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- Authors
- Schilström, B., Svensson, H. M., Svensson, T. H., & Nomikos, G. G.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Nomikos, G.G.
- ORCID
- Nomikos, G.G.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 85
- Issue
- 4
- Pages
- 1005-1009
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2093902619
- Cited by
- 207
- References
- 2
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 10 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 8
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, dopamine release, nucleus accumbens, alpha7 nicotinic acetylcholine receptor, ventral tegmental area, methyllycaconitine, glutamatergic neurotransmission, NMDA receptor, presynaptic modulation, food reward, mesolimbic dopamine system, reward systems
- MeSH terms
- Aconitine, Animals, Dopamine, Food, Nerve Endings, Nicotine, Nucleus Accumbens, Receptors, Nicotinic, Microdialysis, Ventral Tegmental Area, Nicotinic Agonists, Rats, alpha7 Nicotinic Acetylcholine Receptor
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