Cited by 184HIV-related health complications and treatmentsLiver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

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Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy

Sutinen, Jussi, Häkkinen, Anna-Maija, Westerbacka, Jukka, Seppälä-Lindroos, Anneli, Vehkavaara, Satu, Halavaara, Juha, Järvinen, Asko, Ristola, Matti, Yki-Järvinen, Hannele·2002·AIDS

DOI 10.1097/00002030-200211080-00011

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Abstract

OBJECTIVE: To determine liver fat content in patients with highly active antiretroviral therapy (HAART)-associated lipodystrophy. BACKGROUND: Lipodystrophy in several animal models is associated with fat accumulation in insulin-sensitive tissues, such as the liver. This causes hyperinsulinaemia, dyslipidaemia and other features of insulin resistance. DESIGN: A cross-sectional study. SUBJECTS AND METHODS: Three age- and weight-matched groups were compared: 25 HIV-positive men with HAART-associated lipodystrophy (HAART+LD+), nine HIV-positive men receiving HAART, but without lipodystrophy (HAART+LD-), and 35 HIV-negative healthy men (HIV-). Liver fat content was measured using proton spectroscopy. Intra-abdominal and subcutaneous fat were determined using magnetic resonance imaging. RESULTS: Liver fat content was significantly higher in the HAART+LD+ (8 +/- 10%) than the HIV- (5 +/- 7%; P < 0.05) or the HAART+LD- (3 +/- 5%; P < 0.01) group. Liver fat content correlated with serum fasting insulin in the HAART+LD+ (r = 0.47; P < 0.05) and HIV- groups (r = 0.65; < 0.001), but not with the amount of intra-abdominal fat. Within the HAART+LD+ group, serum insulin did not correlate with the amount of intra-abdominal fat. The HAART+LD+ group had a lower serum leptin concentration when compared to the two other groups. Features of insulin resistance, including hepatic fat accumulation, were not found in HAART+LD-group. CONCLUSIONS: The severity of the insulin resistance syndrome in patients with HAART-associated lipodystrophy is related to the extent of fat accumulation in the liver rather than in the intra-abdominal region. Fat accumulation in the liver may therefore play a causative role in the development of insulin resistance in these patients.

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Authors: Sutinen, J., Häkkinen, A.-M., Westerbacka, J., Seppälä-Lindroos, A., Vehkavaara, S., Halavaara, J., Järvinen, A., Ristola, M., & Yki-Järvinen, H.
Affiliations: Helsinki University Hospital (FI)
Corresponding author: Sutinen, Jussi
ORCID: Järvinen, Asko
Ristola, Matti
Venue: AIDS
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-11
Volume: 16
Issue: 16
Pages: 2183-2193
ISSN: 0269-9370 (ISSN-L)
DOI: 10.1097/00002030-200211080-00011
OpenAlex: W2319607702
Cited by: 184
References: 58
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 6
FWCI: 21.55
Type: journal article
Language: en
Open access: closed
Locations: AIDS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: HIV infection, antiretroviral therapy, lipodystrophy, hepatic lipid accumulation, insulin resistance, hyperinsulinemia, leptin, intra-abdominal fat, subcutaneous adipose tissue, 1H NMR, dyslipidemia
MeSH terms: Adipose Tissue, Adult, Cross-Sectional Studies, Humans, Liver, Male, Protons, Spectrum Analysis, HIV Infections, Antiretroviral Therapy, Highly Active, HIV-Associated Lipodystrophy Syndrome

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Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy

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