Cited by 240HIV-related health complications and treatmentsHIV/AIDS drug development and treatmentBone health and osteoporosis research

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Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy

Bruera, Dario, Luna, Norma, David, Daniel O, Bergoglio, Liliana M, Zamudio, Javier·2003·AIDS

DOI 10.1097/00002030-200309050-00010

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Abstract

OBJECTIVE: To describe the alterations in the bone metabolism of HIV-seropositive patients and evaluate the effects of antiretroviral therapies. DESIGN: Cross-sectional analytical study. METHOD AND MATERIALS: A total of 142 subjects (113 male, 29 female), aged 20-45 years were divided into four groups: group A, 33 HIV-seropositive antiretroviral-naive patients; group B1, 36 HIV-seropositive patients on antiviral therapy for over 1 year, without protease inhibitors (PI); group B2, 42 HIV-seropositive patients on combined therapy containing PI for over 1 year; and group C, 15 healthy, HIV-seronegative subjects. Bone mineral density (BMD) were determined by dual energy X-ray absorptiometry in total body, lumbar spine and proximal femur; and evaluation of serum osteocalcin, d-pyridinoline, parathyroid hormone (THP), calcium and phosphate, and urine calcium. RESULTS: BMD was significantly lower in HIV-seropositive patients in comparison with healthy controls, in all sites studied. However, no statistical differences were observed among all groups of HIV-infected patients, independently of the antiretroviral therapy. There was a significantly higher occurrence of osteopenia and osteoporosis in HIV-infected patients in comparison with controls (P < 0.0001), with no differences among treatment-naive patients and either of the treatment groups. Bone formation and resorption markers were similar among all studied groups. There was a significant correlation in all bone sites between time of infection and BMD (P < 0.02). CONCLUSIONS: BMD was significantly lower in HIV-seropositive patients in comparison with controls in lumbar spine, proximal femur and total body, without significant differences among treatment-naive patients and either of the treatment groups. Only time with HIV infection and not specific therapy was associated with BMD decreases.

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Authors: Bruera, D., Luna, N., David, D. O., Bergoglio, L. M., & Zamudio, J.
Affiliations: Universidad Nacional de Córdoba (AR)
Venue: AIDS
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-09
Volume: 17
Issue: 13
Pages: 1917-1923
ISSN: 0269-9370 (ISSN-L)
DOI: 10.1097/00002030-200309050-00010
OpenAlex: W2086774058
Cited by: 240
References: 24
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 10 · 2015: 11 · 2014: 13 · 2013: 9 · 2012: 23
FWCI: 14.20
Type: journal article
Language: en
Open access: closed
Locations: AIDS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: HIV infection, bone mineral density, antiretroviral therapy, protease inhibitors, osteopenia, osteoporosis, bone metabolism, bone formation markers, bone resorption markers, osteocalcin, parathyroid hormone, duration of HIV infection
MeSH terms: Adult, Anthropometry, Bone Diseases, Metabolic, Cross-Sectional Studies, Female, Femur Neck, Humans, Lumbar Vertebrae, Male, Middle Aged, Osteoporosis, Time Factors, Absorptiometry, Photon, Bone Density, HIV Infections, Anti-HIV Agents

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Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy

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