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A Randomized Controlled Trial of Intensive Neurophysiology Education in Chronic Low Back Pain
Abstract
OBJECTIVES: Cognitive-behavioral pain management programs typically achieve improvements in pain cognitions, disability, and physical performance. However, it is not known whether the neurophysiology education component of such programs contributes to these outcomes. In chronic low back pain patients, we investigated the effect of neurophysiology education on cognitions, disability, and physical performance. METHODS: This study was a blinded randomized controlled trial. Individual education sessions on neurophysiology of pain (experimental group) and back anatomy and physiology (control group) were conducted by trained physical therapist educators. Cognitions were evaluated using the Survey of Pain Attitudes (revised) (SOPA(R)), and the Pain Catastrophizing Scale (PCS). Behavioral measures included the Roland Morris Disability Questionnaire (RMDQ), and 3 physical performance tasks; (1) straight leg raise (SLR), (2) forward bending range, and (3) an abdominal "drawing-in" task, which provides a measure of voluntary activation of the deep abdominal muscles. Methodological checks evaluated non-specific effects of intervention. RESULTS: There was a significant treatment effect on the SOPA(R), PCS, SLR, and forward bending. There was a statistically significant effect on RMDQ; however, the size of this effect was small and probably not clinically meaningful. DISCUSSION: Education about pain neurophysiology changes pain cognitions and physical performance but is insufficient by itself to obtain a change in perceived disability. The results suggest that pain neurophysiology education, but not back school type education, should be included in a wider pain management approach.
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In the citing paper
“The only current model, of energetic and personalized explanation of pain, 10 still lacks application in mainstream pain management”
From Patient action as means and end of chronic pain care: Risks and routes to meaningful action (2017) · cites this paper as [10]
In the citing paper
“A previous study looking at the efficacy of brief education intervention found that neurophysiology education led to some normalization of attitudes and beliefs about pain, a reduction in catastrophizing, and improvement in physical performance [20].”
In the citing paper
“This form of pain education (widely known as ‘Explain Pain’ or ‘Pain Neuroscience Education’)15–24 was developed in Australia and has been adapted in numerous Western countries, demonstrating mixed results for effectiveness for managing LBP.15 17 21 23–25”
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“Moreover, exercise, with and without pain physiology education are effective in people with low back pain (Moseley, 2004, 2005; Moseley et al., 2004; Nijs et al., 2014).”
BackgroundJones, M. D., Valenzuela, T., Booth, J., Taylor, J. L., & Barry, B. K. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.07.006 · Cited by 57
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“PNE is an educational strategy used by physical therapists that focuses on teaching people in pain more about the biological and physiological processes involved in their pain experience (Meeus et al., 2010; Moseley, 2002; Moseley, Hodges, and Nicholas, 2004).”
BackgroundExplaining pain following cancer: a practical guide for clinicians
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MethodGardner, T., Refshauge, K. M., McAuley, J. H., Goodall, S., Hübscher, M., & Smith, L. D. (2016) · Spine · doi:10.1097/brs.0000000000001545 · Cited by 50
“By reconceptualizing pain, patients may become more responsive to strategies such as re-engagement with movement and cognitive reframing.(38) The study has several limitations.”
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“Pain neurophysiology education was found to be effective in reducing pain catastrophizing in chronic low back pain patients (Moseley, 2002; Moseley et al., 2004).”
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“…and improvements in patients’ attitudes about pain and improved physical performance (Louw, Diener, Landers, and Puentedura, 2014; Meeus et al, 2010; Moseley, Hodges, and Nicholas, 2004; Moseley, 2002; Puentedura, Brooksby, Wallmann, and Landers, 2009; Ryan, Gray, Newton, and Granat, 2010; Van…”
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“The patient will participate in an educational session about acute and chronic pain [40].”
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“Yet, others indicate the need for more studies to support the clinical utility of pain neuroscience education [3,4] or that this type of education is insufficient by itself to change perceived disability [2,15].”
BackgroundResultInfluentialLópez‐de‐Uralde‐Villanueva, I., Beltrán-Alacreu, H., Fernández‐Carnero, J., & Touche, R. L. (2018) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2018.1480678 · Cited by 46
“Conversely, previous studies have shown that cognitive interventions are associated with a change in both patient attitudes and beliefs regarding pain and physical performance (Morley, Eccleston, and Williams, 1999; Moseley, Nicholas, and Hodges, 2004).”
ResultRomm, M. J., Ahn, S., Fiebert, I. M., & Cahalin, L. P. (2020) · Pain Practice · doi:10.1111/papr.12962 · Cited by 47
“Moseley(35) 7 2002 LBP disability 57 Chronic lower back pain Pain intensity 57 Moseley et al.(36) 8 2004 LBP disability 58 Chronic lower back pain Pain attitudes 58 Pain catastrophizing 58 Beltran-Alacreu et al.”
BackgroundWerner, E. L., Storheim, K., Løchting, I., Wisløff, T., & Grotle, M. (2016) · SPINE · doi:10.1097/brs.0000000000001268 · Cited by 43
Ma, X., Chen, R., Wei, L., & Huang, P. (2023) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2023.2232003 · Cited by 51
“Five trials (364 participants) investigated the short-term effect of PNE on pain catastrophizing (Alves, Puentedura, and Silva, 2022; Bodes Pardo et al., 2018; Løchting et al., 2016; Moseley, Nicholas, and Hodges, 2004; Sharma, Jensen, Moseley, and Abbott, 2019).”
InfluentialLouw, A., Puentedura, E. J., & Mintken, P. E. (2011) · Physiotherapy Theory and Practice · doi:10.3109/09593985.2011.562602 · Cited by 43
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Salazar‐Méndez, J., Núñez‐Cortés, R., Suso‐Martí, L., Ribeiro, I. L., Garrido-Castillo, M., Gacitúa, J., Méndez-Rebolledo, G., Cruz‐Montecinos, C., López‐Bueno, R., & Calatayud, J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105328 · Cited by 41
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The use of pain neuroscience education in older adults with chronic back and/or lower extremity pain
Rufa, A., Beissner, K., & Dolphin, M. (2018) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2018.1456586 · Cited by 42
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“…with drawings of action potentials (Moseley, 2004; Van Oosterwijck et al, 2011) was used to describe: peripheral sensitization (Moseley, 2004; Moseley, Hodges, and Nicholas, 2004; Van Oosterwijck et al, 2011); central sensitization (Moseley, 2004; Moseley, Hodges, and Nicholas, 2004; Van…”
BackgroundMethodInfluentialInterdisciplinary Pain Neuroscience Continuing Education in the Veterans Affairs
Louw, A., Vogsland, R., Marth, L. A., Marshall, P., Cox, T., & Landers, M. R. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000756 · Cited by 41
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“The intervention was based on other interventions described in clinical trials for other pain conditions (Moseley et al., 2004; Louw et al., 2011; Louw et al., 2014).”
MethodReconciling movement and exercise with pain neuroscience education: A case for consistent education
Blickenstaff, C., & Pearson, N. (2016) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2016.1194653 · Cited by 39
“…various chronic pain disorders (Louw, Diener, Butler, and Puentedura, 2011; Louw, Diener, Landers, and Puentedura, 2014; Meeus et al, 2010; Moseley, 2002; Moseley, 2003; Moseley, 2004; Moseley, 2005; Moseley, Nicholas, and Hodges, 2004; Van Oosterwijck et al, 2011; Van Oosterwijck et al, 2013).”
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“However previous research suggests traditional training about spinal anatomy and biomechanics is ineffective or even harmful as it can encourage clinical practice recommendations which are not consistent with clinical guidelines [15, 56].”
Ghavipanje, V., Rahimi, N. M., & Akhlaghi, F. (2021) · Biological Research For Nursing · doi:10.1177/10998004211044828 · Cited by 38
“Besides, paying attention to the “abled-self” rather than “disabled-self” as one of DNS principles compare to GE can assist the patients to have more reassurance about what they can do (Burton et al., 1999; Frank et al., 2013; Kolar & Kobesova, 2010; Milić, 2020; Moseley et al., 2004).”
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“Educating patients on the nature of their disorder and on the physiology of pain has likewise been found to result in improvements in both objective functional and subjective pain measurements for complex conditions such as chronic low back pain (Moseley et al., 2004).”
BackgroundPain Neuroscience Education: Teaching People About Pain
Louw, A., & Riera-Gilley, V. (2024) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/15360288.2024.2424853 · Cited by 36
“• 68% cartilage damage seen in pain-free adults on imaging (39). the underlying biology of their pain experience, vs. only providing a tissue-based explanation (45).”
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“Although, the dosage of PNE sessions highly vary between studies, from one single session (of a duration of 3 h) in the study of Moseley et al. (2004) to four sessions in the study of Werner et al. (2016) Therefore it might be important to conduct follow-up educational sessions including a…”
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A Child’s Concept of Pain: An International Survey of Pediatric Pain Experts
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Self-citationPreoperative education for lumbar surgery for radiculopathy
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“Changes in these impairments are known to occur immediately after many interventions including superficial heat (38), long wave ultrasound (38), Short wave diathermy (39) mobilization (40, 41), mobilization with movement (35) manipulation (42, 43), specific exercises (44) and even changes in the patient’s knowledge an…”
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Inciting events associated with lumbar disc herniation
Suri, P., Hunter, D. J., Jouve, C., Hartigan, C., Limke, J. C., Peña, E., Swaim, B. H., Li, L., & Rainville, J. (2010) · The Spine Journal · doi:10.1016/j.spinee.2010.02.003 · Cited by 34
“Indeed, prior work has shown that direct evidencebased education delivered by provider to patient can improve outcomes in spine care, including disability [24].”
State of The Art in Biobehavioral Approaches to the Management of Chronic Pain in Childhood
Simons, L. E., & Basch, M. C. (2015) · Pain Management · doi:10.2217/pmt.15.59 · Cited by 31
Stilwell, P., & Harman, K. (2017) · PubMed Central · Cited by 31
Stanton, T. R., Karran, E. L., Butler, D. S., Hull, M. J., Schwetlik, S. N., BRAITHWAITE, F., Jones, H. G., Moseley, G. L., Hill, C. L., Tomkins‐Lane, C., et al. (2020) · PAIN Reports · doi:10.1097/pr9.0000000000000830 · Cited by 35
Self-citationCashin, A. G., Lee, H., Traeger, A. C., Moseley, G. L., Hübscher, M., Kamper, S. J., Skinner, I., & McAuley, J. H. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.07.007 · Cited by 30
Self-citationMartínez-Calderón, J., Ho, E. K., Ferreira, P. H., García‐Muñoz, C., Villar-Alises, O., & Matias-Soto, J. (2023) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2023.11833 · Cited by 30
Neurodynamics in a broader perspective
Butler, D. S., & Coppieters, M. W. (2007) · Manual Therapy · doi:10.1016/j.math.2007.01.001 · Cited by 30
Aguiar, A. D. S., Moseley, G. L., Bataglion, C., Azevedo, B. O., & Chaves, T. C. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.09.012 · Cited by 28
Self-citationTransforming Pain With Prosocial Meaning: A Functional Magnetic Resonance Imaging Study
López‐Solà, M., Koban, L., & Wager, T. D. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000609 · Cited by 29
Orhan, C., Lenoir, D., Favoreel, A., Looveren, E. V., Kabak, V. Y., Mukhtar, N. B., Cagnie, B. J., & Meeus, M. (2019) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2019.1639231 · Cited by 29
“The improvement in pain beliefs and attitudes measured by the Survey of Pain Attitudes was found immediately after PNE application (Moseley, 2004; Moseley, Nicholas, and Hodges, 2004).”
MethodResultThorn, B. E. (2020) · Pain · doi:10.1097/j.pain.0000000000001839 · Cited by 30
Rundell, S. D., & Davenport, T. E. (2010) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2010.3264 · Cited by 29
Koechlin, H., Locher, C., & Prchal, A. (2020) · Children · doi:10.3390/children7100179 · Cited by 29
Teaching patients about pain: It works, but what should we call it?
Louw, A., Puentedura, E. J., & Zimney, K. J. (2016) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2016.1194669 · Cited by 29
“…been referred to as: “Explaining Pain to Patients” (Gifford and Muncey, 1999); “Explain Pain” (Butler and Moseley, 2013); “Pain Neurobiology Education” (Moseley, Hodges, and Nicholas, 2004); “Pain Neurophysiology Education” (Clarke, Ryan, and Martin, 2011; Moseley, Hodges, and Nicholas, 2004;…”
Louw, A., Schmidt, S. G., Louw, C., & Puentedura, E. J. (2015) · Physiotherapy Theory and Practice · doi:10.3109/09593985.2015.1060656 · Cited by 29
“…current best-evidence of pain neuroscience education, despite the pain, the patient displayed improved movements, showing a potential reconceptualization of her pain, which is a cornerstone of a pain science approach (Louw, Diener, Butler, and Puentedura, 2011; Moseley, Nicholas, and Hodges, 2004).”
BackgroundMethodTherapeutic neuroscience education via e-mail: a case report
Louw, A. (2014) · Physiotherapy Theory and Practice · doi:10.3109/09593985.2014.912255 · Cited by 29
Sullivan, N., Hebron, C., & Vuoskoski, P. (2019) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2019.1672227 · Cited by 33
Pain-related psychological issues in hand therapy
Hamasaki, T., Pelletier, R., Bourbonnais, D., Harris, P., & Choinière, M. (2018) · Journal of Hand Therapy · doi:10.1016/j.jht.2017.12.009 · Cited by 28
Slepian, P. M., Bernier, E., Scott, W., Niederstrasser, N. G., Wideman, T. H., & Sullivan, M. J. L. (2013) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-013-9432-2 · Cited by 27
“neurophysiological education [10], goal setting and activity”
BackgroundNijs, J., Mannerkorpi, K., Descheemaeker, F., & Houdenhove, B. V. (2010) · Physical Therapy · doi:10.2522/ptj.20100046 · Cited by 27
Goudman, L., Huysmans, E., Ickmans, K., Nijs, J., Moens, M., Putman, K. D., Buyl, R., Louw, A., Logghe, T., & Coppieters, I. (2019) · Physical Therapy · doi:10.1093/ptj/pzz053 · Cited by 32
Chronic nonmalignant pain: a challenge for patients and clinicians
Scascighini, L., & Sprott, H. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0680 · Cited by 26
Klinger, R., & Flor, H. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-44519-8_13 · Cited by 26
“The ability of patients to understand such neurophysiological and neurobiological connections tends to be underestimated; yet such an education has in itself a significant positive effect on the perception of pain (Moseley et al. 2004).”
BackgroundMansell, G., Storheim, K., Løchting, I., Werner, E. L., & Grotle, M. (2017) · Physical Therapy · doi:10.1093/ptj/pzx091 · Cited by 27
Teaching People About Pain: Why do we Keep Beating Around the Bush?
Moseley, G. L. (2011) · Pain Management · doi:10.2217/pmt.11.73 · Cited by 26
Self-citationTankha, H., Lumley, M. A., Gordon, A., Schubiner, H. H., Uipi, C., Harris, J., Wager, T. D., & Ashar, Y. K. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.04.006 · Cited by 25
Murillo, C., Galán-Martín, M. Á., Montero-Cuadrado, F., Lluch, E., Meeus, M., & Loh, W. W. (2023) · Pain · doi:10.1097/j.pain.0000000000002929 · Cited by 25
Louw, A., Farrell, K. P., Choffin, B., Foster, B., Lunde, G., Snodgrass, M., Sweet, R. A., Weitzel, M., Wilder, R., & Puentedura, E. J. (2019) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2019.1624006 · Cited by 25
“an inclinometer placed on the tibial crest 5 cm distal to the inferior border of the patella on the most affected leg [9,41,42].”
BackgroundMethodResultInfluentialCeballos‐Laita, L., Mingo-Gómez, M. T., Cámara, F. J. N., Estébanez-de-Miguel, E., Caudevilla-Polo, S., Verde, Z., Araque, A. F., & Jiménez‐del‐Barrio, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113564 · Cited by 27
“PNE has been shown to change pain cognition and normalize emotions and beliefs about pain [20], improving endogenous nociceptive inhibition in patients with FMS [41].”
BackgroundThe clinical implementation of pain neuroscience education: A survey study
Louw, A., Puentedura, E. J., Zimney, K. J., Cox, T., & Rico, D. (2017) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2017.1359870 · Cited by 25
Metadata
- Authors
- Moseley, G. L., Nicholas, M. K., & Hodges, P. W.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Moseley, G. Lorimer
- Hodges, Paul W.
- Venue
- The Clinical Journal of Pain
- Published
- 2004
- Volume
- 20
- Issue
- 5
- Pages
- 324-330
- ISSN
- 0749-8047 (ISSN-L)
- OpenAlex
- W2078673653
- Cited by
- 537
- References
- 50
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 36 · 2023: 32 · 2022: 24 · 2021: 50 · 2020: 45 · 2019: 31 · 2018: 34 · 2017: 31 · 2016: 40 · 2015: 34 · 2014: 18 · 2013: 20 · 2012: 16
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- neurophysiology education, chronic low back pain, pain-related cognitions, pain catastrophizing, pain attitudes, disability, physical performance, cognitive-behavioral pain management, physiotherapy education
- MeSH terms
- Adult, Analysis of Variance, Chronic Disease, Double-Blind Method, Female, Humans, Male, Middle Aged, Neurophysiology, Pain Measurement, Patient Education as Topic, Psychomotor Performance, Surveys and Questionnaires, Cognitive Behavioral Therapy, Low Back Pain
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