The DOI matches its Crossref record; 111 of the 113 references it cites were found in a registry or an index.
Customization of Pain Treatments: Single-Case Design and Analysis
Abstract
The aim of this paper is to acquaint pain researchers and practitioners with recent developments in the single-case experimental approach and their potential to allow for tailoring the treatment and its evaluation to the specific complaints, aptitudes, or profile of the individual patient, without violating the canons of good science and practice. After contrasting the single-case experimental approach and the case-study approach, we show the possibilities of customization in design, measurement, and test statistics. This is done by distinguishing 2 types of single-case designs--alternation designs and phase designs--and 2 types of replication strategies--simultaneous replications and sequential replications. In addition, tailor-made randomization tests are proposed for alternation, phase, and simultaneous replication designs and the combining of P values to perform a meta-analysis on designs that are sequentially replicated. With our emphasis on: 1) randomization in the design; 2) the possibilities for a statistical test (together with the determination of power and the calculation of effect sizes); 3) the importance of reliable and valid measurement; and 4) the role of replication, we demonstrate how internal validity, statistical-conclusion validity, construct validity, and external validity concerns can be dealt with within a single-case experimental approach framework. Finally, the many research examples and references to clinical work illustrate the usefulness of the approach.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“SCED studies can provide a clear understanding of change in outcomes and processes at the individual level, and a perspective on therapeutic mechanisms that considerably expands upon findings from RCTs (Onghena & Edgington, 2005;Vlaeyen et al., 2020).”
From Acceptance and Commitment Therapy for women living with Vulvodynia: A single-case experimental design study of a treatment delivered online (2022) · cites this paper as Onghena & Edgington, 2005
In the citing paper
“Compared with RCTs, n-of-1 study designs use repeated measurements to provide a more fine-graded, time-sensitive and context-sensitive picture of individual trajectories and pattern, thus allowing to evaluate effects at the within-person level.23”
From Development, evaluation and implementation of a digital behavioural health treatment for chronic pain: study protocol of the multiphase DAHLIA project (2022) · cites this paper as [23]
Citations
Cites
(1984) · Cited by 81,983
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,421
(1963) · Medical Entomology and Zoology · Cited by 15,085
(2002) · Cited by 13,211
(1979) · Medical Entomology and Zoology · Cited by 11,252
Experimental Design: Procedures for the Behavioral Sciences
Kirk, R. (2013) · doi:10.4135/9781483384733 · Cited by 8,539
Testing Statistical Hypotheses
Niewiadomska-Bugaj, M., & Bartoszynski, R. (2021) · Wiley series in probability and statistics · doi:10.1002/9781119243830.ch12 · Cited by 5,188
SOME CURRENT DIMENSIONS OF APPLIED BEHAVIOR ANALYSIS1
Baer, D. M., Wolf, M. M., & Risley, T. R. (1968) · Journal of Applied Behavior Analysis · doi:10.1901/jaba.1968.1-91 · Cited by 3,935
Single Case Experimental Designs: Strategies for Studying Behavior Change
Barlow, D. H., Nock, M. K., & Hersen, M. (1976) · Cited by 3,036
Research works printed but not linked: 14
- Kazdin, 1981, J Consult Clin Psychol, 49, 183, 10.1037/0022-006X.49.2.183 · DOI
- Edgington, 1980, Behav Assess, 2, 19
- Holden, 2002, Res Soc Work Pract, 36, 21
- 1986, Lancet, 1, 1254
- Onghena, 1992, Behav Assess, 14, 153
- Wampold, 1986, Behav Assess, 8, 135
- Wolery, 1982, Behav Assess, 4, 93
- Knapp, 1983, Behav Assess, 5, 155
- Crosbie, 1993, J Consult Clin Psychol, 61, 966, 10.1037/0022-006X.61.6.966 · DOI
- Kempthorne, 1955, JASA, 50, 964
- Edgington, 1964, J Psychol, 57, 445, 10.1080/00223980.1964.9916711 · DOI
- White, 1989, Behav Assess, 11, 281
- Senchaudhuri, 1995, J Am Stat Assoc, 90, 640
- Larson, 1990, West J Med, 152, 52
Cited by
Sorted by citations
Kratochwill, T. R., & Levin, J. R. (2010) · Psychological Methods · doi:10.1037/a0017736 · Cited by 497
Vlaeyen, J. W. S., Maher, C. G., Wiech, K., Van Zundert, J., Meloto, C. B., Diatchenko, L., Battié, M. C., Goossens, M., Koes, B., & Linton, S. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0052-1 · Cited by 497
Krasny-Pacini, A., & Evans, J. (2018) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2017.12.002 · Cited by 373
Cognitive-Behavioral Treatments for Chronic Pain: What Works for Whom?
Vlaeyen, J. W. S., & Morley, S. (2005) · The Clinical Journal of Pain · doi:10.1097/00002508-200501000-00001 · Cited by 350
“Onghena and Edgington present a current state of the art of the application of randomization tests.(64) Not only have they scrutinized possible applications for randomization tests, but they also provide the possibility to repeat the test over accumulated data sets, similar to meta-analyses performed in systematic rev…”
de Jong, J. R., Vlaeyen, J. W. S., Onghena, P., Cuypers, C., den Hollander, M., & Ruijgrok, J. M. (2005) · Pain · doi:10.1016/j.pain.2005.04.019 · Cited by 289
“Complex regional pain syndrome type I (CRPS-I) is a poorly understood chronic pain disorder with regard to pathophysiology and treatment.”
BackgroundMethodSelf-citation
Metadata
- Authors
- Onghena, P., & Edgington, E. S.
- Affiliations
- KU Leuven (BE)
- University of Calgary (CA)
- Corresponding author
- Onghena, Patrick
- ORCID
- Onghena, Patrick
- Venue
- The Clinical Journal of Pain
- Published
- 2005-01
- Volume
- 21
- Issue
- 1
- Pages
- 56-68
- ISSN
- 0749-8047 (ISSN-L)
- OpenAlex
- W2117635631
- Cited by
- 188
- References
- 113
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 17 · 2018: 7 · 2017: 12 · 2016: 8 · 2015: 9 · 2014: 5 · 2013: 6 · 2012: 10
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- single-case experimental design, pain management, personalized treatment, replication strategies, permutation tests, combining p-values, meta-analysis, internal validity, statistical conclusion validity, construct validity, generalizability, reliability and validity, effect size, power analysis
- MeSH terms
- Data Interpretation, Statistical, Humans, Research Design, Reproducibility of Results, Randomized Controlled Trials as Topic, Pain Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
