Significance of Candida recovered from intraoperative specimens in patients with intra-abdominal perforations
Abstract
Objective Determine the significance of recovering yeasts from intraoperative specimens from the abdominal cavity and to evaluate the effect of a single intraoperative dose of fluconazole on clinical outcome in patients with intra-abdominal perforations. Design Prospective, randomized, double-blind study. Setting Multicenter study from 13 hospitals in Norway. Patients One hundred nine patients with intra-abdominal perforations. Interventions Patients were randomized to receive either a single 400-mg fluconazole dose or placebo during the operation. Measurements and main results An intra-abdominal specimen for microbiological culture was obtained at the time of the operation. The primary response variable in the study was death. Secondary response variables were three parameters indicating a complicated postoperative period: mechanical ventilation for > or = 5 days, intensive care treatment for > or = 10 days, and use of a central venous catheter for > or = 10 days. Yeasts were recovered from a intraoperative intra-abdominal specimen from only 1 (3.5%) of 28 patients with perforated appendicitis and from 32 (39.5%) of 81 nonappendicitis patients. Excluding the appendicitis patients, the yeast recovery rate was high both for patients hospitalized at the time of the perforation (45%) and for nonhospitalized patients (32%). The overall mortality was 11% (12 patients). Single-dose intraoperative fluconazole prophylaxis did not reach a statistically significant effect on mortality…
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Other studies did not observe an association between antimicrobial timing and mortality.
“Other studies, however, did not observe an association between antimicrobial timing and mortality (112-117).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [117]
Cites
Constant Low Rate of Fungemia in Norway, 1991 to 1996
Sandven, P., Bevanger, L., Digranes, A., Gaustad, P., Haukland, H. H., Steinbakk, M., & The Norwegian Yeast Study Group (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.12.3455-3459.1998 · Cited by 82 · see citing works
Self-citationYeast Colonization in Surgical Patients with Intra-Abdominal Perforations
Sandven, P., & Giercksky, K. E. (2001) · European Journal of Clinical Microbiology and Infections Diseases · doi:10.1007/s100960100531 · Cited by 36 · see citing works
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Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174 · see citing works
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440 · see citing works
Epidemiology of Candida species infections in critically ill non-immunosuppressed patients
Eggimann, P., Garbino, J., & Pittet, D. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00801-6 · Cited by 900 · see citing works
Changes in the epidemiological landscape of invasive candidiasis
Lamoth, F., Lockhart, S. R., Berkow, E. L., & Calandra, T. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx444 · Cited by 547 · see citing works
Fungal Infections in Patients with Severe Acute Pancreatitis and the Use of Prophylactic Therapy
De Waele, J. J., Vogelaers, D., Blot, S., & Colardyn, F. (2003) · Clinical Infectious Diseases · doi:10.1086/375603 · Cited by 156 · see citing works
Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment
Vergidis, P., Clancy, C. J., Shields, R. K., Park, S. Y., Wildfeuer, B. N., Simmons, R. L., & Nguyen, M. H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0153247 · Cited by 150 · see citing works
Invasive candidiasis in immunocompromised hospitalized patients.
Sims, C. R., Ostrosky-Zeichner, L., & Rex, J. H. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.05.015 · Cited by 124 · see citing works
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Antifungal agents for preventing fungal infections in non-neutropenic critically ill patients
Cortegiani, A., Russotto, V., Maggiore, A., Attanasio, M., Naro, A. R., Raineri, S. M., & Giarratano, A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004920.pub3 · Cited by 91 · see citing works
Occurrence, presentation and treatment of candidemia
Mikulska, M., Del Bono, V., Ratto, S., & Viscoli, C. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.12.52 · Cited by 71 · see citing works
Prophylaxis, empirical and preemptive treatment of invasive candidiasis
Playford, E. G., Lipman, J., & Sorrell, T. C. (2010) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32833e10e8 · Cited by 41 · see citing works
- Authors
- Sandven, P., Qvist, H., Skovlund, E., & Giercksky, K. E.
- Affiliations
- Norwegian Institute of Public Health (NO)
- ORCID
- Skovlund, Eva
- Venue
- Critical Care Medicine
- Published
- 2002-03
- Volume
- 30
- Issue
- 3
- Pages
- 541-547
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2000724121
- Cited by
- 201
- References
- 2
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 17 · 2019: 5 · 2018: 9 · 2017: 15 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Abdominal Surgery and Complications
- Health Sciences › Medicine › Surgery › Surgical site infection prevention
- Keywords
- Candida, appendiceal perforation, postoperative mortality, mechanical ventilation, intensive care, central venous catheters, spontaneous perforation, cancer patients, fungal infection risk, abdominal surgery, postoperative complications, prognostic factors, risk stratification
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Candidiasis, Double-Blind Method, Female, Humans, Intestinal Perforation, Intraoperative Care, Male, Middle Aged, Norway, Peritonitis, Postoperative Complications, Prognosis, Risk, Rupture, Stomach Diseases, Fluconazole
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