Yeast Colonization in Surgical Patients with Intra-Abdominal Perforations

Sandven, P.; Giercksky, K. E.

doi:10.1007/s100960100531

Cited by 36Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesNosocomial Infections in ICU

Yeast Colonization in Surgical Patients with Intra-Abdominal Perforations

Sandven, P., Giercksky, K. E.·2001·European Journal of Clinical Microbiology and Infections Diseases

DOI 10.1007/s100960100531

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Abstract

A prospective study was conducted to determine (i) the degree of yeast colonization in surgical patients with intra-abdominal perforations and (ii) whether the frequency of colonization is different in patients with a complicated postoperative course than in patients recovering uneventfully. A total of 1,496 specimens taken per- and post-operatively from the mouth, stomach, feces, urine, trachea, and abdomen of 109 surgical patients with intra-abdominal perforations were examined. Yeast was recovered from 98 (90%) of the patients and from 634 (42%) of the specimens. Approximately 70% of the specimens from the mouth and stomach, 47% of fecal specimens, and 31% of abdominal specimens were positive for yeast. A total of 42 patients had a complicated postoperative course. The majority of these patients were colonized with yeast at multiple body sites: yeast was recovered on one or more occasions from two or more body sites in 90% and from three or more body sites in 71%. Many of the patients with an uncomplicated postoperative course also were colonized: yeast was recovered from two or more body sites in 69% and from three or more body sites in 34%. The results of this study indicate that treatment recommendations based on yeast colonization will expose a large number of patients to unnecessary or even harmful antifungal treatment. This does not mean that yeast colonization is insignificant; however, more accurate criteria and methods based on prospective clinical studies are needed to detect patients at risk of developing severe Candida infection.

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Authors: Sandven, P., & Giercksky, K. E.
Affiliations: Norwegian Institute of Public Health (NO)
Venue: European Journal of Clinical Microbiology and Infections Diseases
Publisher: Springer Science and Business Media LLC
Published: 2001-07
Volume: 20
Issue: 7
Pages: 0475-0481
ISSN: 0934-9723 (ISSN-L)
DOI: 10.1007/s100960100531
OpenAlex: W2049789111
Cited by: 36
References: 22
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2013: 1
FWCI: 1.03
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords: yeast colonization, postoperative complications, Candida, antifungal therapy, surgical patients
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Female, Follow-Up Studies, Humans, Intestinal Perforation, Male, Middle Aged, Mycoses, Postoperative Complications, Postoperative Period, Preoperative Care, Probability, Prospective Studies, Risk Factors, Yeasts, Colony Count, Microbial, Incidence, Survival Rate

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Yeast Colonization in Surgical Patients with Intra-Abdominal Perforations

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