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Cited by 325

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Multicenter postapproval clinical trial of Integra dermal regeneration template for burn treatment

Heimbach, David M., Warden, Glenn D., Luterman, Arnold, Jordan, Marion H., Ozobia, Nathan, Ryan, Colleen M., Voigt, David W., Hickerson, William L., Saffle, Jeffrey R., DeClement, Frederick A., Sheridan, Robert L., Dimick, Alan R.·2003·The Journal of Burn Care & Rehabilitation
DOI 10.1097/00004630-200301000-00009
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Abstract

The safety and effectiveness of Integra® Dermal Regeneration Template was evaluated in a postapproval study involving 216 burn injury patients who were treated at 13 burn care facilities in the United States. The mean total body surface area burned was 36.5% (range, 1–95%). Integra® was applied to fresh, clean, surgically excised burn wounds. Within 2 to 3 weeks, the dermal layer regenerated, and a thin epidermal autograft was placed. The incidence of invasive infection at Integra®-treated sites was 3.1% (95% confidence interval, 2.0–4.5%) and that of superficial infection 13.2% (95% confidence interval, 11.0–15.7%). Mean take rate of Integra® was 76.2%; the median take rate was 95%. The mean take rate of epidermal autograft was 87.7%; the median take rate was 98%. This postapproval study further supports the conclusion that Integra® is a safe and effective treatment modality in the hands of properly trained clinicians under conditions of routine clinical use at burn centers.

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Research works printed but not linked: 31

  1. Yannas, 1982, Wound tissue can utilize a polymeric template to synthesize a functional extension of skin, Science., 215, 174, 10.1126/science.7031899 · DOI
  2. Yannas, 1989, Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin, Proc Natl Acad Sci U S A., 86, 933, 10.1073/pnas.86.3.933 · DOI · Paper page
  3. Burke, 1981, Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury, Ann Surg., 194, 413, 10.1097/00000658-198110000-00005 · DOI · Paper page
  4. Stern, 1990, Histologic study of artificial skin used in the treatment of full-thickness thermal injury, J Burn Care Rehabil., 11, 7, 10.1097/00004630-199001000-00003 · DOI · Paper page
  5. Garner, 1988, CDC definitions for nosocomial infections, 1988, Am J Infect Control., 16, 128, 10.1016/0196-6553(88)90053-3 · DOI
  6. Clayton, 1998, Perioperative and postoperative dressing techniques for Integra Artificial Skin: views from two medical centers, J Burn Care Rehabil., 19, 358, 10.1097/00004630-199807000-00017 · DOI
  7. Chamania, 1998, A retrospective analysis of early excision and skin grafting from 1993–1995, Burns., 24, 177, 10.1016/S0305-4179(97)00117-4 · DOI
  8. Petersen, 1982, The incidence of bacteremia following burn wound excision, J Trauma., 22, 274, 10.1097/00005373-198204000-00002 · DOI
  9. Herndon, 1987, Determinants of mortality in pediatric patients with greater than 70% full-thickness total body surface area thermal injury treated by early total excision and grafting, J Trauma., 27, 208, 10.1097/00005373-198702000-00020 · DOI
  10. McManus, 1989, Excision of the burn wound in patients with large burns, Arch Surg., 124, 718, 10.1001/archsurg.1989.01410060088018 · DOI
  11. Renz, 1992, The burn unit experience at Grady Memorial Hospital: 844 cases, J Burn Care Rehabil., 13, 426, 10.1097/00004630-199207000-00008 · DOI
  12. Germann, 1997, The impact of risk factors and pre-existing conditions on the mortality of burn patients and the precision of predictive admission-scoring systems, Burns., 23, 195, 10.1016/S0305-4179(96)00112-X · DOI
  13. Wolf, 1997, Mortality determinants in massive pediatric burns: an analysis of 103 children with ≥80% TBSA burns (≥70% full-thickness), Ann Surg., 225, 554, 10.1097/00000658-199705000-00012 · DOI
  14. Clark, 1986, Mortality probability in victims of fire trauma: revised equation to include inhalation injury, Br Med J Clin Res Ed., 292, 1303, 10.1136/bmj.292.6531.1303 · DOI
  15. Thompson, 1986, Effect on mortality of inhalation injury, J Trauma., 26, 163, 10.1097/00005373-198602000-00012 · DOI
  16. Shirani, 1987, The influence of inhalation injury and pneumonia on burn mortality, Ann Surg., 205, 82, 10.1097/00000658-198701000-00015 · DOI
  17. Tredget, 1990, The role of inhalation injury in burn trauma: Canadian experience, Ann Surg., 212, 720, 10.1097/00000658-199012000-00011 · DOI
  18. Vico, 1992, Factors involved in burn mortality: a multivariate statistical approach based on discriminant analysis, Burns., 18, 212, 10.1016/0305-4179(92)90071-2 · DOI
  19. Zöch, 1992, Comparison of prognostic indices for burns and assessment of their accuracy, Burns., 18, 109, 10.1016/0305-4179(92)90005-F · DOI
  20. Rue, 1993, Improved survival of burned patients with inhalation injury, Arch Surg., 128, 772, 10.1001/archsurg.1993.01420190066009 · DOI
  21. Smith, 1994, Effect of inhalation injury, burn size, and age on mortality: a study of 1447 consecutive burn patients, J Trauma., 37, 655, 10.1097/00005373-199410000-00021 · DOI
  22. Saffle, 1995, Recent outcomes in the treatment of burn injury in the United States: a report from the American Burn Association Patient Registry, J Burn Care Rehabil., 16, 219, 10.1097/00004630-199505000-00002 · DOI
  23. Coste, 1996, Predicting mortality in adult burned patients: methodological aspects of the construction and validation of a composite ratio scale, J Clin Epidemiol., 49, 1125, 10.1016/0895-4356(96)00197-7 · DOI
  24. Ryan, 1998, Objective estimates of the probability of death from burn injuries, N Engl J Med., 338, 362, 10.1056/NEJM199802053380604 · DOI
  25. Go′mez-Ci′a, 1999, Mortality according to age and burned body surface in the Virgen del Rocio University Hospital, Burns., 25, 317, 10.1016/S0305-4179(98)00126-0 · DOI
  26. King, 2000, Artificial skin reduces nutritional requirements in a severely burned child, Burns., 26, 501, 10.1016/S0305-4179(99)00186-2 · DOI
  27. Boyce, 1999, The clinical research award: cultured skin substitutes combined with Integra Artificial Skin to replace native skin autograft and allograft for the closure of excised full-thickness burns, J Burn Care Rehabil., 1999, 453, 10.1097/00004630-199920060-00006 · DOI
  28. Loss, 2000, Artificial skin, split-thickness autograft and cultured autologous keratinocytes combined to treat a severe burn injury of 93% of TBSA, Burns., 26, 644, 10.1016/S0305-4179(00)00045-0 · DOI
  29. Kremer, 2000, Evaluation of dermal-epidermal skin equivalents ('composite-skin') of human keratinocytes in a collagen-glycosaminoglycan matrix (Integra® Artificial Skin), Br J Plast Surg., 53, 459, 10.1054/bjps.2000.3368 · DOI
  30. Lorenz, 1997, Early wound closure and early reconstruction: experience with a dermal substitute in a child with 60 per cent surface area burn, Burns., 23, 505, 10.1016/S0305-4179(97)00022-3 · DOI
  31. Hunt, 2000, Initial experience of Integra in the treatment of post-burn anterior cervical neck contracture, Br J Plast Surg., 53, 652, 10.1054/bjps.2000.3436 · DOI

Cited by

Metadata

Authors
Heimbach, D. M., Warden, G. D., Luterman, A., Jordan, M. H., Ozobia, N., Ryan, C. M., Voigt, D. W., Hickerson, W. L., Saffle, J. R., DeClement, F. A., Sheridan, R. L., & Dimick, A. R.
Affiliations
  • Department of Surgery, University of Washington, Seattle, Washington
  • Shriners Burn Institute, Cincinnati, Ohio
  • Department of Surgery, University of South Alabama, Mobile, Alabama
  • Washington Hospital Center, Washington, DC
  • Lions Burns Care Center, Las Vegas, Nevada
  • Shriners Burns Institute, Massachusetts General Hospital, Boston, Massachusetts
  • St Elizabeth's Regional Burn Center, Lincoln, Nebraska
  • University of Tennessee Medical Group, Memphis, Tennessee
  • Burn Trauma Unit, University of Utah Hospital and Clinic, Salt Lake City, Utah
  • St. Agnes Burn Center, Philadelphia, Pennsylvania
  • Burn Institute–Boston Unit, Shriners Hospital for Children, Boston, Massachusetts
  • Department of Surgery, University of Alabama, and Birmingham, Alabama.
Venue
The Journal of Burn Care & Rehabilitation
Publisher
Oxford University Press (OUP)
Published
2003-01-01
Volume
24
Issue
1
Pages
42-48
ISSN
  • 0273-8481
  • 1534-5939
DOI
10.1097/00004630-200301000-00009
Cited by
325
References
0
Language
en

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