Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts
Open accessAbstract
Background: Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. scaffolds and tissue grafts), due to their compositional biofunctionality and cytocompatibility, are under investigation as potential stem cell carriers. Methods: The present study assessed the potential of three commercially available extracellular matrix-based biomaterials [a collagen/glycosaminoglycan scaffold (Integra™ Matrix Wound Dressing), a decellularised porcine peritoneum (XenoMEM™) and a porcine urinary bladder (MatriStem™)] as human adipose-derived stem cell delivery vehicles. Results: Both tissue grafts induced significantly (p < 0.01) higher human adipose-derived stem cell proliferation in vitro over the collagen scaffold, especially when the cells were seeded on the basement membrane side. Human adipose-derived stem cell phenotype and trilineage differentiation potential was preserved in all biomaterials. In a splinted wound healing nude mouse model, in comparison to sham, biomaterials alone and cells alone groups, all biomaterials seeded with human adipose-derived stem cells showed a moderate improvement of wound closure, a significantly (p < 0.05) lower wound gap and scar index and a significantly (p < 0.05) higher proportion of mature collagen deposition and angiogenesis (the highest,p < 0.01, was observed for the cell loaded at the basement membrane XenoMEM™ group). All cell-loaded biomaterial groups retained more cells at the implantation side than the direct injection group, even though they were loaded with half of the cells than the cell injection group. Conclusions: This study further advocates the use of extracellular matrix-based biomaterials (in particular porcine peritoneum) as human adipose-derived stem cell delivery vehicles. Graphical abstract: Comparative analysis of a collagen scaffold (Integra™ Matrix Wound Dressing) and two tissue grafts [decellularised porcine peritoneum (XenoMEM™) and porcine urinary bladder (MatriStem™)] as human adipose-derived stem cells carriers
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The basement membrane site of porcine peritoneum elicits significantly different responses in the same cell type in vitro compared to the connective tissue side.
“For instance, the basement membrane site of porcine peritoneum has been shown to elicit significantly different responses in the same cell type in vitro when compared to the connective tissue side [152,153]”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [152]
The Methods (In vitro cytocompatibility assessment; no page given) confirm that the same human adipose-derived stem cells were cultured on both sides of porcine peritoneum. The Results (Cytocompatibility analysis; no page given) report side-dependent proliferation patterns, but their stated significance comparisons are against the tissue-culture-plastic control, not directly between the basement-membrane and connective-tissue sides. The claimed statistically significant difference between those two sides is therefore not established by the cited passages. (LLM, conf=0.84)
Experimental — accuracy not yet measuredECM degradation peptides promote M2-like phenotypes in vitro and in vivo.
“promotion of M2-like phenotypes in vitro [40,44,153] and in vivo [152,154,155].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [152]
The Results > Immunohistochemical analysis reports blood-vessel formation and cell counts in mouse wounds, but not M2-like phenotypes. Searches for M2 macrophage polarization, ECM degradation peptides, and macrophage markers found no passage linking degradation peptides to M2-like phenotypes in vivo; this paper therefore does not verify the part of the citing sentence attributed to an in vivo source. Page numbers were unavailable in our copy. (LLM, conf=0.74)
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Potential of extracellular space for tissue regeneration in dentistry
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A preliminary preclinical assessment of macromolecular crowding in tissue engineering
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Hierarchical approaches and regenerative applications of adipose tissue derivatives
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- Authors
- Capella-Monsonís, H., De Pieri, A., Peixoto, R., Korntner, S., & Zeugolis, D. I.
- Affiliations
- Science Foundation Ireland (IE)
- Corresponding author
- Zeugolis, Dimitrios I.
- Venue
- Stem Cell Research & Therapy
- Published
- 2020-11-27
- Volume
- 11
- Issue
- 1
- Pages
- 510-510
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC7694925
- OpenAlex
- W3108178114
- Cited by
- 42
- References
- 61
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 7 · 2014: 1
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science Foundation Ireland (13/RC/2073 & 15/CDA/3629)
- European Research Council (866126)
- H2020 Marie Skłodowska-Curie Actions (676338)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- adipose-derived stem cells, wound healing, collagen scaffolds, xenografts, stem cell proliferation, trilineage differentiation, angiogenesis, collagen deposition, nude mouse model
- MeSH terms
- Adipose Tissue, Animals, Biocompatible Materials, Collagen, Extracellular Matrix, Stem Cells, Swine, Wound Healing, Tissue Scaffolds, Heterografts
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