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Cited by 51Blood Pressure and Hypertension StudiesTreatment of Major DepressionCardiac Health and Mental Health

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Blood Pressure Changes During Short-Term Fluoxetine Treatment

Amsterdam, Jay D., Garcia-Espana, Felipe, Fawcett, Jan, Quitkin, Frederick M., Reimherr, Frederick W., Rosenbaum, Jerrold F., Beasley, Charles·1999·Journal of Clinical Psychopharmacology
DOI 10.1097/00004714-199902000-00004
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Abstract

Recent reports of sustained hypertension in some patients receiving venlafaxine have rekindled concerns about antidepressant-induced hypertension. This study examined sitting and standing systolic and diastolic blood pressure, pulse rate, and rate of sustained hypertension in 796 depressed patients (mean +/- SD age, 40 +/- 11 years) taking fluoxetine 20 mg daily for up to 12 weeks. A modest reduction in sitting and standing systolic (p < 0.001) and diastolic (p < 0.001) blood pressure measures were observed in the entire patient sample. Patients with pretreatment diastolic blood pressure < 60 mmHg (N = 32) showed a modest increase in mean diastolic blood pressure (p < 0.001), whereas patients with pretreatment diastolic blood pressure > or = 90 mmHg and < or = 95 mmHg (N = 57) had a modest reduction in mean diastolic blood pressure (p < 0.001). Patients with preexisting, stable cardiovascular disease (including hypertension) (N = 35) showed no significant blood pressure change (p = not significant). Of the patients receiving fluoxetine, 1.7% had sustained hypertension for > or = 3 consecutive clinic visits-a rate significantly lower than that previously reported with venlafaxine (4.8%) (chi2 = 13.3, p < 0.001) and similar to that previously seen with placebo (2.1%). In conclusion, these data demonstrate a low rate of sustained hypertension (1.7%) during short-term fluoxetine treatment.

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Crossref · 10.1097/00004714-199902000-00004

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21 of 21 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 6

  1. Simpson, 1984, J Clin Psychiatry, 45, 59
  2. Potter, 1991, N Engl J Med, 329, 633
  3. Feighner, 1995, J Clin Psychiatry, 56, 574
  4. Feighner, 1990, J Clin Psychiatry, 51, 222
  5. Grubb, 1995, Eur J Card Pacing Electrophysiol, 5, 306
  6. Guelfi, 1995, J Clin Psychiatry, 56, 450

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Metadata

Authors
Amsterdam, J. D., Garcia-Espana, F., Fawcett, J., Quitkin, F. M., Reimherr, F. W., Rosenbaum, J. F., & Beasley, C.
Affiliations
University of Utah (US)
ORCID
Beasley, Charles
Venue
Journal of Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-02
Volume
19
Issue
1
Pages
9-14
ISSN
0271-0749 (ISSN-L)
DOI
10.1097/00004714-199902000-00004
OpenAlex
W2319421857
Cited by
51
References
21
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 3 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 1
FWCI
0.73
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
fluoxetine, blood pressure, venlafaxine, depression, sustained hypertension, diastolic blood pressure, cardiovascular adverse events, antidepressants
MeSH terms
Adolescent, Adult, Aged, Blood Pressure, Depression, Double-Blind Method, Female, Fluoxetine, Humans, Hypertension, Male, Middle Aged, Antidepressive Agents, Second-Generation

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