Myelin Water Fraction in Human Cervical Spinal Cord In Vivo

In vivo visualization of myelin water in brain by magnetic resonance

MacKay, A. L., Whittall, K. P., Adler, J., Li, D. K. B., Paty, D. W., & Graeb, D. A. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910310614 · Cited by 916 · see citing works

In vivo measurement of T 2 distributions and water contents in normal human brain

Whittall, K. P., MacKay, A. L., Graeb, D. A., Nugent, R. A., Li, D. K. B., & Paty, D. W. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370107 · Cited by 796 · see citing works

Quantitative interpretation of NMR relaxation data

Whittall, K. P., & MacKay, A. L. (1989) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(89)90011-5 · Cited by 633 · see citing works

On standardizing the MR image intensity scale

Ny�l, L. G., & Udupa, J. K. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199912)42:6 · Cited by 567 · see citing works

Practical T2 quantitation for clinical applications

Poon, C. S., & Henkelman, R. M. (1992) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880020512 · Cited by 396 · see citing works

Water content and myelin water fraction in multiple sclerosis

Laule, C., Vavasour, I. M., Moore, G. R. W., Oger, J. J.-F., Li, D. K. B., Paty, D. W., & MacKay, A. L. (2004) · Journal of Neurology · doi:10.1007/s00415-004-0306-6 · Cited by 369 · see citing works

Compensation for pulse imperfections in NMR spin-echo experiments

Levitt, M. H., & Freeman, R. (1981) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(81)90082-2 · Cited by 286 · see citing works

Determination of relative CMRO2 from CBF and BOLD changes: Significant increase of oxygen consumption rate during visual stimulation

Kim, S., Rostrup, E., Larsson, H. B. W., Ogawa, S., & Paulson, O. B. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199906)41:6 · Cited by 267 · see citing works

Is multicomponent T2 a good measure of myelin content in peripheral nerve?

Webb, S., Munro, C. A., Midha, R., & Stanisz, G. J. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10411 · Cited by 172 · see citing works

Spin‐spin relaxation in experimental allergic Encephalomyelitis. Analysis of CPMG data using a non‐linear least squares method and linear inverse theory

Stewart, W. A., MacKay, A. L., Whittall, K. P., Moore, G. R. W., & Paty, D. W. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290608 · Cited by 128 · see citing works

Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance

Barkhof, F., & van Walderveen, M. A. A. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0511 · Cited by 107 · see citing works

Linear combination of multiecho data: Short T2 component selection

Jones, C. K., Xiang, Q., Whittall, K. P., & MacKay, A. L. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10713 · Cited by 38 · see citing works

Chapter 25 Remyelination and restoration of axonal function by glial cell transplantation

Zhang, S., & Duncan, I. D. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)27026-x · Cited by 30 · see citing works

Time-of-flight MR angiography with Gd-DTPA hexamethylene diamine co-polymer blood pool contrast agent: Comparison of enhanced MRA and conventional angiography for arterial stenosis induced in rabbits

Bonk, R. T., Schmiedl, U. P., Yuan, C., Nelson, J. A., BLACK, C. D. V., & Ladd, D. L. (2000) · Journal of Magnetic Resonance Imaging · doi:10.1002/1522-2586(200006)11:6 · Cited by 10 · see citing works

Myelin water imaging of multiple sclerosis at 7 T: Correlations with histopathology

Laule, C., Kozłowski, P., Leung, E., Li, D. K. B., MacKay, A. L., & Moore, G. R. W. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.008 · Cited by 379 · see citing works

The current state-of-the-art of spinal cord imaging: Methods

Stroman, P. W., Wheeler‐Kingshott, C. A. M. G., Bacon, M., Schwab, J. M., Bosma, R. L., Brooks, J. C. W., Cadotte, D. W., Carlstedt, T. P., Ciccarelli, O., Cohen‐Adad, J., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.124 · Cited by 332 · see citing works

Magnetic Resonance Imaging of Myelin

Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.004 · Cited by 334 · see citing works

Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?

Grussu, F., Schneider, T., Tur, C., Yates, R. L., Tachrount, M., Ianuş, A., Yiannakas, M. C., Newcombe, J., Zhang, H., Alexander, D. C., et al. (2017) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.445 · Cited by 291 · see citing works

Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin

MacKay, A. L., & Laule, C. (2016) · Brain Plasticity · doi:10.3233/bpl-160033 · Cited by 288 · see citing works

Practical medical applications of quantitative MR relaxometry

Cheng, H. M., Stikov, N., Ghugre, N. R., & Wright, G. A. (2012) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23718 · Cited by 238 · see citing works

Neurite imaging reveals microstructural variations in human cerebral cortical gray matter

Fukutomi, H., Glasser, M. F., Zhang, H., Autio, J. A., Coalson, T. S., Okada, T., Togashi, K., Van Essen, D. C., & Hayashi, T. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.02.017 · Cited by 234 · see citing works

Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI

Martin, A. R., Aleksanderek, I., Cohen‐Adad, J., Tarmohamed, Z., Tetreault, L. A., Smith, N., Cadotte, D. W., Crawley, A. P., Ginsberg, H. J., Mikulis, D. J., et al. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.11.019 · Cited by 234 · see citing works

Myelin quantification with MRI: A systematic review of accuracy and reproducibility

van der Weijden, C. W. J., García, D. V., Borra, R., Thurner, P., Meilof, J., van Laar, P. V., Dierckx, R., Gutmann, I. W., & de Vries, E. D. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117561 · Cited by 118 · see citing works

Characterizing White Matter Damage in Rat Spinal Cord with Quantitative MRI and Histology

Kozlowski, P., Raj, D., Liu, J., Lam, C., Yung, A. C., & Tetzlaff, W. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0462 · Cited by 129 · see citing works

Multiexponential T2 and magnetization transfer MRI of demyelination and remyelination in murine spinal cord

McCreary, C. R., Bjarnason, T. A., Skihar, V., Mitchell, J. R., Yong, V. W., & Dunn, J. F. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.071 · Cited by 107 · see citing works

Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status

van der Weijden, C. W. J., Biondetti, E., Gutmann, I. W., Dijkstra, H., McKerchar, R., Faria, D. D. P., de Vries, E. F. J., Meilof, J. F., Dierckx, R., Prévost, V., et al. (2022) · Brain · doi:10.1093/brain/awac436 · Cited by 95 · see citing works

MR Relaxation in Multiple Sclerosis

MacKay, A. L., Vavasour, I. M., Rauscher, A., Kolind, S., Mädler, B., Moore, G. R. W., Traboulsee, A. L., Li, D. K. B., & Laule, C. (2008) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2008.09.007 · Cited by 94 · see citing works

Myelin water imaging to detect demyelination and remyelination and its validation in pathology

Laule, C., & Moore, G. R. W. (2018) · Brain Pathology · doi:10.1111/bpa.12645 · Cited by 93 · see citing works

Comparison of myelin water fraction from multiecho T2 decay curve and steady‐state methods

Zhang, J., Kolind, S., Laule, C., & MacKay, A. L. (2014) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25125 · Cited by 89 · see citing works

Myelin water imaging: Implementation and development at 3.0T and comparison to 1.5T measurements

Kolind, S., Mädler, B., Fischer, S., Li, D. K. B., & MacKay, A. L. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21966 · Cited by 76 · see citing works

Long T2 water in multiple sclerosis: What else can we learn from multi-echo T2 relaxation?

Laule, C., Vavasour, I. M., Kolind, S., Traboulsee, A. L., Moore, G. R. W., Li, D. K. B., & MacKay, A. L. (2007) · Journal of Neurology · doi:10.1007/s00415-007-0595-7 · Cited by 73 · see citing works

Two-year study of cervical cord volume and myelin water in primary progressive multiple sclerosis

Laule, C., Vavasour, I. M., Zhao, Y., Traboulsee, A. L., Oger, J. J.-F., Vavasour, J., MacKay, A. L., & Li, D. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510365586 · Cited by 73 · see citing works

Multicenter measurements of myelin water fraction and geometric mean T2: Intra‐ and intersite reproducibility

Meyers, S. M., Vavasour, I. M., Mädler, B., Harris, T., Fu, E., Li, D. K. B., Traboulsee, A. L., MacKay, A. L., & Laule, C. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24106 · Cited by 70 · see citing works

Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods

Meyers, S. M., Laule, C., Vavasour, I. M., Kolind, S., Mädler, B., Tam, R. C., Traboulsee, A. L., Lee, J., Li, D. K. B., & MacKay, A. L. (2009) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2009.02.001 · Cited by 70 · see citing works

Dynamic tractography: Integrating cortico-cortical evoked potentials and diffusion imaging

Silverstein, B. H., Asano, E., Sugiura, A., Sonoda, M., Lee, M., & Jeong, J. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116763 · Cited by 67 · see citing works

High‐resolution myelin water measurements in rat spinal cord

Kozłowski, P., Liu, J., Yung, A. C., & Tetzlaff, W. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21527 · Cited by 64 · see citing works

MR evidence of long T2 water in pathological white matter

Laule, C., Vavasour, I. M., Mädler, B., Kolind, S., Sirrs, S. M., Brief, E., Traboulsee, A. L., Moore, G. R. W., Li, D. K. B., & MacKay, A. L. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21132 · Cited by 63 · see citing works

Brain and cord myelin water imaging: a progressive multiple sclerosis biomarker

Kolind, S., Seddigh, A., Combes, A. J. E., Russell‐Schulz, B., Tam, R. C., Yogendrakumar, V., Deoni, S., Sibtain, N. A., Traboulsee, A. L., Williams, S., et al. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.10.002 · Cited by 56 · see citing works

Microstructural imaging in the spinal cord and validation strategies

Cohen-Adad, J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.009 · Cited by 50 · see citing works

Visualization of cytoplasmic diffusion within living myelin sheaths of CNS white matter axons using microinjection of the fluorescent dye Lucifer Yellow

Velumian, A. A., Samoilova, M., & Fehlings, M. G. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.022 · Cited by 49 · see citing works

Myelin water measurement in the spinal cord

Minty, E. P., Bjarnason, T. A., Laule, C., & MacKay, A. L. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21936 · Cited by 48 · see citing works

Reproducibility of in vivo magnetic resonance imaging–based measurement of myelin water

Levesque, I. R., Chia, C. L. L., & Pike, G. B. (2010) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22170 · Cited by 45 · see citing works

Complementary information from multi-exponential T2 relaxation and diffusion tensor imaging reveals differences between multiple sclerosis lesions

Kolind, S. H., Laule, C., Vavasour, I. M., Li, D. K. B., Traboulsee, A. L., Mädler, B., Moore, G. R. W., & MacKay, A. L. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.033 · Cited by 44 · see citing works

Rapid three‐dimensional multicomponent relaxation imaging of the cervical spinal cord

Kolind, S., & Deoni, S. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22634 · Cited by 39 · see citing works

High-resolution myelin water imaging in post-mortem multiple sclerosis spinal cord: A case report

Laule, C., Yung, A. C., Pavolva, V., Bohnet, B., Kozłowski, P., Hashimoto, S. A., Yip, S. S. F., Li, D. K. B., & Moore, G. W. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458515624559 · Cited by 37 · see citing works

Myelin water and T2 relaxation measurements in the healthy cervical spinal cord at 3.0T: Repeatability and changes with age

MacMillan, E. L., Mädler, B., Fichtner, N., Dvorak, M. F., Li, D. K. B., Curt, A. E. P., & MacKay, A. L. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.076 · Cited by 35 · see citing works

The effect of varying echo spacing within a multiecho acquisition: better characterization of long T2 components

Skinner, M. G., Kolind, S., & MacKay, A. L. (2007) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2006.09.046 · Cited by 34 · see citing works

Modeling white matter microstructure

Duval, T. (2016) · Functional Neurology · doi:10.11138/fneur/2016.31.4.217 · Cited by 31 · see citing works

Rapid myelin water imaging in human cervical spinal cord

Ljungberg, E., Vavasour, I. M., Tam, R. C., Yoo, Y., Rauscher, A., Li, D. K. B., Traboulsee, A. L., MacKay, A. L., & Kolind, S. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26551 · Cited by 30 · see citing works

Scan–rescan of axcaliber, macromolecular tissue volume, and g‐ratio in the spinal cord

Duval, T., Smith, V., Stikov, N., Klawiter, E. C., & Cohen‐Adad, J. (2017) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26945 · Cited by 28 · see citing works

Measuring the Absolute Water Content of the Brain Using Quantitative MRI

Shah, N. J., Ermer, V., & Oros‐Peusquens, A. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-992-5_3 · Cited by 26 · see citing works

Rapid myelin water imaging for the assessment of cervical spinal cord myelin damage

Dvorak, A. V., Ljungberg, E., Vavasour, I. M., Liu, H., Johnson, P., Rauscher, A., Kramer, J. L. K., Tam, R. C., Li, D. K. B., Laule, C., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101896 · Cited by 24 · see citing works

Changes in T2 Relaxation Times Associated with Maturation of the Human Intervertebral Disk

Krueger, E. C., Perry, J. O., Wu, Y., & Haughton, V. M. (2007) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0546 · Cited by 24 · see citing works

Utility of MRI in Quantifying Tissue Injury in Cervical Spondylotic Myelopathy

Khan, A. F., Haynes, G., Mohammadi, E., Muhammad, F., Hameed, S., & Smith, Z. A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093337 · Cited by 22 · see citing works

Temporal phase correction of multiple echo T2 magnetic resonance images

Bjarnason, T. A., Laule, C., Bluman, J., & Kozłowski, P. (2013) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2013.02.019 · Cited by 16 · see citing works

Mapping the rest of the human connectome: Atlasing the spinal cord and peripheral nervous system

Andrei Irimia, A., & Horn, J. D. V. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117478 · Cited by 11 · see citing works

Pain and spinal cord imaging measures in children with demyelinating disease

Barakat, N., Gorman, M., Benson, L., Becerra, L. R., & Borsook, D. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.08.019 · Cited by 8 · see citing works

Myelin Water Imaging

MacKay, A. L., & Laule, C. (1996) · Encyclopedia of Magnetic Resonance · doi:10.1002/9780470034590.emrstm1270 · Cited by 4 · see citing works

Imaging Considerations in Spinal Cord Evaluation

Shea, A., Kuo, A. H., & Hsu, L. (2021) · Seminars in Neurology · doi:10.1055/s-0041-1725969 · Cited by 3 · see citing works

T2 Relaxation

Laule, C., & MacKay, A. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-396973-6.00013-7 · Cited by 2 · see citing works

Impact of the acquisition protocol on the sensitivity to demyelination and axonal loss of clinically feasible DWI techniques: a simulation study

Oliviero, S., & Gratta, C. D. (2021) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-020-00899-5 · Cited by 2 · see citing works

Quantitative magnetic resonance imaging of magnetization transfer and T2 relaxation in human white matter pathology

Levesque, I. R. (2009) · eScholarship@McGill (McGill) · doi:10.82308/33389 · Cited by 2 · see citing works

Inflammatory Demyelinating Diseases

Pirko, I., & Guttmann, C. R. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-396973-6.00002-2 · Cited by 1 · see citing works

Micro-anatomical characterization of central white matter using magnetic resonance imaging.

Dula, A. N. (2008) · Europe PMC (PubMed Central) · Cited by 1 · see citing works

Imaging of the Spinal Cord

Stechishin, O. D. M., Heran, M. K. S., Shewchuk, J. R., Vertinsky, A. T., & Laule, C. (2022) · Springer eBooks · doi:10.1007/978-3-030-99906-3_3

Myelin water measurement in the spinal cord

Minty, E. P., Bjarnason, T. A., Laule, C., & MacKay, A. L. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21936 · Cited by 48 · see citing works

In vivo visualization of myelin water in brain by magnetic resonance

MacKay, A. L., Whittall, K. P., Adler, J., Li, D. K. B., Paty, D. W., & Graeb, D. A. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910310614 · Cited by 916 · see citing works

Assessment of the myelin water fraction in rodent spinal cord using T2-prepared ultrashort echo time MRI

Klasen, T., & Faber, C. (2016) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-016-0579-7 · Cited by 1 · see citing works

Myelin Water Fraction and Intra/Extracellular Water Geometric Mean T2Normative Atlases for the Cervical Spinal Cord from 3T MRI

Liu, H., Ljungberg, E., Dvorak, A. V., Lee, L. E., Yik, J. T., MacMillan, E. L., Barlow, L. R., Li, D. K. B., Traboulsee, A. L., Kolind, S., et al. (2019) · Journal of Neuroimaging · doi:10.1111/jon.12659 · Cited by 19 · see citing works

Myelin water measurement by magnetic resonance imaging in the healthy human spinal cord : reproducibility and changes with age

MacMillan, E. L. (2008) · cIRcle (University of British Columbia) · doi:10.14288/1.0066616