Reduced baroreflex changes in muscle sympathetic nerve activity during blood pressure elevation in essential hypertension
Abstract
To determine whether the baroreflex control of sympathetic nerve activity is altered in patients with essential hypertension, muscle sympathetic nerve activity (MSNA) was recorded microneurographically from the tibial nerves of 23 normotensive subjects and 23 patients with essential hypertension. When phenylephrine (2 micrograms/kg) was injected intravenously, although the pressor response of mean arterial blood pressure (MAP) was significantly enhanced in the hypertensives as compared with the normotensives, the reflex decrease in MSNA was significantly smaller in the hypertensives. Furthermore, the baroreflex slope for MSNA, used as an index of baroreflex sensitivity and calculated by relating the change in MSNA to the change in MAP, was significantly less in the hypertensives. Following the injection of nitroglycerin (2 micrograms/kg), there were no significant differences between the normotensives and hypertensives in the depressor response, the reflex increase in MSNA or the baroreflex slope for MSNA. These observations suggest that the baroreflex change in sympathetic nerve activity is reduced during phenylephrine-induced blood pressure elevation but not during nitroglycerin-induced hypotension in the hypertensives, and that the blunted response of sympathetic nerve activity occurring during hypertension in these hypertensive patients may underlie the maintenance of high blood pressure in essential hypertension.
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The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects.
“The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects (15,16,25,26,28).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [26]
Patients with hypertension have a greater frequency of MSNA bursts than properly matched normotensive subjects.
“Despite the difficulty of establishing that every unit within a burst has a vasoconstrictor role, there is a wealth of evidence to suggest that patients with hypertension have a greater frequency of MSNA bursts than properly matched normotensive subjects (15,25–27).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [26]
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Feig, D. I. (2005) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.09.006 · Cited by 22 · see citing works
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Baroreflex control of muscle sympathetic nerve activity in mild hypertension
Meyrelles, S. S. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00353-6 · Cited by 13 · see citing works
Domingos-Souza, G., Santos‐Almeida, F. M., Meschiari, C. A., Ferreira, N. S., Pereira, C. A., Pestana‐Oliveira, N., Prates-Costa, T. C., Tostes, R. C., White, C., & Fazan, R. (2021) · Hypertension Research · doi:10.1038/s41440-021-00639-9 · Cited by 13 · see citing works
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BackgroundKaplan, N. M. (1992) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199204000-00012 · Cited by 11 · see citing works
Westfall, T. C., Macarthur, H., Byku, M., Yang, C.-L., & Murray, J. M. (2013) · Advances in pharmacology · doi:10.1016/b978-0-12-411512-5.00006-3 · Cited by 10 · see citing works
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BackgroundSelf-citationCraig, J. C., Broxterman, R. M., Cerbie, J., et al. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00057.2021 · Cited by 9 · see citing works
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Iwase, S., Mano, T., Saito, M., & Ishida, G. (1991) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(91)90043-3 · Cited by 8 · see citing works
O’Leary, D. S., Mannozzi, J. T., Augustyniak, R. A., et al. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00093.2022 · Cited by 8 · see citing works
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Boyes, N. G., Klassen, S. A., Baker, S. E., et al. (2024) · Journal of Neurophysiology · doi:10.1152/jn.00277.2024 · Cited by 5 · see citing works
Maier, L. E., Meyer, S. E., Deprato, A., Busch, S. A., Sivak, A., Davenport, M. H., & Steinback, C. D. (2025) · Autonomic Neuroscience · doi:10.1016/j.autneu.2025.103251 · Cited by 5 · see citing works
“Chronic hypertension results in impairment of the baroreceptors and chemoreceptors (Matsukawa et al., 1991; Si ´ nski et al., 2012), which may further contribute to blunted responses to exercise in cardiovascular diseases.”
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Hamaoka, T., Leuenberger, U. A., Blaha, C., Luck, J. C., Sinoway, L. I., & Cui, J. G. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2022 · Cited by 5 · see citing works
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Groom, A. S., & Malpas, S. C. (1997) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1997.tb01812.x · Cited by 5 · see citing works
Zeinivand, M., Shamsizadeh, A., Pourshanazari, A., et al. (2014) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2014_143 · Cited by 4 · see citing works
“In patients with cardiovascular disease who showing impaired BRS, such as patients with hypertension (49) and heart failure (50), impaired barorefl ex function may leading signifi cant tachycardia and sympathetic activation during cigarette smoking (51).”
BackgroundWang, T., Takabatake, T., Kobayashi, Y., & Nabika, T. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04990.x · Cited by 4 · see citing works
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BackgroundEffect of metoclopramide on muscle sympathetic nerve activity in humans
Takeuchi, Y., Matsukawa, T., Sugiyama, Y., et al. (1996) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(95)00137-9 · Cited by 4 · see citing works
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BackgroundRafieian, M., Farbu, E. H., Höper, A. C., Valtonen, R. I. P., Hyrkäs-Palmu, H., Perkiömäki, J. S., Crandall, C. G., Jaakkola, J. J. K., & Ikäheimo, T. M. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1558471 · Cited by 4 · see citing works
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Makai, A., Gallardo, R., TRAYKOV, V. B., Sághy, L., Pap, R., Forster, T., Rudas, L., & Bogáts, G. (2010) · EP Europace · doi:10.1093/europace/euq032 · Cited by 1 · see citing works
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BackgroundWhite, D. W., & Fernhall, B. (2015) · Molecular and translational medicine · doi:10.1007/978-3-319-17076-3_9 · Cited by 1 · see citing works
Effects of Exercise Training on Heart Rate Variability in Patients with Hypertension
Millar, P. J., McGowan, C. L. M., & McCartney, N. (2012) · CRC Press eBooks · doi:10.1201/b12756-11 · Cited by 1 · see citing works
Controle neurovascular de corredores amadores hipertensos
Perlingeiro, P. D. S. (2014) · doi:10.11606/t.5.2014.tde-09022015-103310
Sugita, N., Yoshizawa, M., Tanaka, A., Abe, M., Homma, N., Chiba, S., Yambe, T., & Nitta, S. I. (2011) · Displays · doi:10.1016/j.displa.2011.04.003
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PROTEOMIC ANALYSIS OF THE HYPERTENSIVE PHENOTYPE IN RATS
McDonald, T. G. (2014) · QSpace (Queen's University Library)
- Authors
- Matsukawa, T., Gotoh, E., Hasegawa, O., Shionoiri, H., Tochikubo, O., & Ishii, M.
- Affiliations
- Yokohama City University (JP)
- ORCID
- Ishii, Masao
- Venue
- Journal of Hypertension
- Published
- 1991-06
- Volume
- 9
- Issue
- 6
- Pages
- 537-542
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2049957143
- Cited by
- 65
- References
- 0
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- essential hypertension, baroreflex sensitivity, muscle sympathetic nerve activity, sympathetic nervous system, blood pressure regulation, phenylephrine pressor response
- MeSH terms
- Adult, Blood Pressure, Female, Nitroglycerin, Humans, Hypertension, Male, Muscles, Phenylephrine, Pressoreceptors, Reflex, Sympathetic Nervous System, Tibial Nerve
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