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Cited by 174Blood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic ControlCardiovascular and exercise physiology

Single-Unit Sympathetic Discharge: Quantitative Assessment in Human Hypertensive Disease

Greenwood, John P., Stoker, John B., Mary, David A. S. G.·1999·Circulation
DOI 10.1161/01.cir.100.12.1305
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Abstract

Background —Reports demonstrating sympathetic hyperactivity in hypertension with the use of microneurography have been inconsistent. One possible reason is that previous studies have assessed muscle sympathetic nerve activity (MSNA) from integrated voltage waves (“bursts”) recorded from multiunit discharges. We studied single units with defined vasoconstrictor properties (s-MSNA) to further characterize sympathetic output in hypertensive disease. Methods and Results —We examined 74 subjects with a wide range of arterial blood pressure that were considered to be either normal (NT), high normal (HN), or stages 1 to 3 essential hypertension (EHT-1, EHT-2/3). All had their peripheral sympathetic activity measured from both multiunit bursts and single-unit vasoconstrictor impulses. There was a significant correlation between s-MSNA and MSNA, and results of variability studies were similar. The EHT-1 and EHT-2/3 groups had greater s-MSNA and MSNA than did the matched NT group (always P <0.01). The HN group also had greater s-MSNA and MSNA than did the NT group (mean±SEM; 43±5 vs 29±2 impulses/100 beats, P <0.05; 36±4 vs 24±2 bursts/100 beats, P <0.05). In addition, the EHT-1 group had significantly greater s-MSNA than did the EHT-2/3 group (63±6 vs 51±3 impulses/100 beats, P <0.05), which could not be demonstrated with MSNA bursts. Conclusions —Quantification from single vasoconstrictor units has provided additional evidence in established essential hypertension of increased central sympathetic output. Furthermore, in the mild or early stages of hypertension, this technique has provided new evidence of augmented sympathetic output compared with more severe hypertension.

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Crossref · 10.1161/01.cir.100.12.1305

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  • Under resting conditions, the variability between repeat recordings of both s-MSNA and MSNA is less than 8%.

    “Finally, although the technique of microneurography is selective for the particular unit(s) studied, under resting conditions the variability between repeat recordings of both s-MSNA and MSNA is <8% (16).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]

  • The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects.

    “The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects (15,16,25,26,28).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]

  • In stage 1 hypertensive disease, peripheral sympathetic drive is higher than in more severe degrees of hypertension.

    “more recently, we have shown that, in stage 1 hypertensive disease, the peripheral sympathetic drive is, in fact, higher than that found in the more severe degrees of hypertension (16).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]

  • In patients with moderate to severe hypertension, sympathetic output was lower or equal compared with matched groups with milder hypertension, depending on whether single units or multiunits were examined.

    “More recently, we have shown that patients with moderate to severe hypertension had either lower or equal sympathetic output compared with matched groups with milder hypertension, depending on whether single units or multiunits were examined (16).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]

  • In the former study, subjects with severe hypertension had a high left ventricular mass index, whereas in the latter study left ventricular hypertrophy was excluded.

    “Finally, and perhaps most importantly, subjects with severe hypertension in the former study had a high LVMI, whereas, in the latter study, LVH was excluded.”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]

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Authors
Greenwood, J. P., Stoker, J. B., & Mary, D. A. S. G.
Affiliations
University of Leeds (GB)
ORCID
Greenwood, John P.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-09-21
Volume
100
Issue
12
Pages
1305-1310
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.100.12.1305
OpenAlex
W2001261464
Cited by
174
References
29
Citations by year
2026: 1 · 2024: 5 · 2023: 8 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 14 · 2012: 10
FWCI
5.51
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
British Heart Foundation
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
essential hypertension, sympathetic nervous system, muscle sympathetic nerve activity, sympathetic hyperactivity, early hypertension, high-normal blood pressure, microneurography
MeSH terms
Action Potentials, Adult, Female, Humans, Hypertension, Male, Middle Aged, Sympathetic Nervous System, Vasoconstriction

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