The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Role of the sympathetic nervous system in human hypertension
Abstract
Animal studies have shown conclusively that sympathetic neural factors are involved in the development and/or maintenance of high blood pressure. Whether this is also the case for human hypertension has been documented less conclusively, owing to technical difficulties in assessing human adrenergic function. Recent studies have used sophisticated and sensitive techniques to evaluate sympathetic activity in humans, e.g. the norepinephrine spillover method and the microneurographic quantification of sympathetic nerve traffic, allowing documentation of the participation of adrenergic mechanisms in the early and late phases of the hypertensive process. Evidence has been also provided that the activation of the sympathetic nervous system (1) is peculiar to the essential hypertensive state, (2) parallels the degree of the blood pressure elevation, (3) is triggered by reflex and humoral mechanisms and (4) may exert deleterious metabolic and cardiovascular effects, accelerating the progression of the end organ damage accompanying hypertension. These findings explain why non-pharmacological and pharmacological approaches to the treatment of hypertension should be aimed not only at lowering elevated blood pressure values but also at exerting sympathoinhibitory effects.
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Cites
Cardiovascular neural regulation explored in the frequency domain.
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Physiological aspects of primary hypertension.
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Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man
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Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
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Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions
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Baroreflex Control of Sympathetic Nerve Activity in Essential and Secondary Hypertension
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Self-citationRegional Sympathetic Nervous Activity and Oxygen Consumption in Obese Normotensive Human Subjects
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Cited by
Potential causes, mechanisms, and implications of post exercise hypotension
MacDonald, J. R. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001377 · Cited by 502
Sympathetic Activation in the Pathogenesis of Hypertension and Progression of Organ Damage
Mancia, G., Grassi, G., Giannattasio, C., & Seravalle, G. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.724 · Cited by 471
Self-citationHow to assess sympathetic activity in humans
Grassi, G., & Esler, M. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917060-00001 · Cited by 455
Self-citationHering, D., Lambert, E. A., Marusic, P., Walton, A. S., Krum, H., Lambert, G. W., Esler, M. D., & Schlaich, M. P. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00194 · Cited by 356
Impact of Type 2 Diabetes Mellitus on Sympathetic Neural Mechanisms in Hypertension
Huggett, R. J., Scott, E. M., Gilbey, S. G., Stoker, J. B., Mackintosh, A. F., & Mary, D. A. S. G. (2003) · Circulation · doi:10.1161/01.cir.0000103123.66264.fe · Cited by 305
Metadata
- Authors
- Grassi, G.
- Venue
- Journal of Hypertension
- Published
- 1998-12
- Volume
- 16
- Issue
- Supplement
- Pages
- 1979-1987
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2054323238
- Cited by
- 289
- References
- 19
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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