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Cited by 72Blood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic ControlReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

The ‘adrenaline hypothesis’ of hypertension revisited: evidence for adrenaline release from the heart of patients with essential hypertension

Rumantir, Magdalena S., Jennings, Garry L., Lambert, Gavin W., Kaye, David M., Seals, Douglas R., Esler, Murray D.·2000·Journal of Hypertension
DOI 10.1097/00004872-200018060-00009
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Abstract

OBJECTIVE: Whether adrenaline acts as a sympathetic nervous cotransmitter in humans and stimulates beta2-adrenoceptors to augment neuronal noradrenaline release remains a subject of considerable dispute. The aim of this study was to test if adrenaline is released from regional sympathetic nerves (in the heart) in patients with essential hypertension, and to investigate whether locally released adrenaline might enhance cardiac noradrenaline release. METHODS: Using dual isotope dilution methodology, adrenaline and noradrenaline plasma kinetics was measured for the whole body and in the heart in 13 untreated patients with essential hypertension and 27 healthy volunteers. All research participants underwent cardiac catheterization under resting conditions. RESULTS: At rest, there was negligible adrenaline release from the sympathetic nerves of the heart in healthy subjects, 0.27 +/- 1.62 ng/min. In contrast, in patients with essential hypertension, adrenaline was released from the heart at a rate of 1.46 +/- 1.73 ng/min, equivalent on a molar basis to approximately 5% of the associated cardiac noradrenaline spillover value. Cardiac noradrenaline spillover was higher in hypertensive patients, 24.9 +/- 17.0 ng/min compared to 15.4 +/- 11.7 ng/min in healthy volunteers (P< 0.05). Among patients, rates of cardiac adrenaline and noradrenaline spillover correlated directly (r= 0.59, P< 0.05). CONCLUSIONS: This study, in demonstrating release of adrenaline from the heart in patients with essential hypertension, and in disclosing a proportionality between rates of cardiac adrenaline and noradrenaline release, provides perhaps the most direct evidence to date in support of the 'adrenaline hypothesis' of essential hypertension.

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Crossref · 10.1097/00004872-200018060-00009

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Research works printed but not linked: 7

  1. Cassis, 1985, J Pharmacol Exp Ther, 234, 792
  2. Carmona, 1985, Br J Physiol, 86, 351
  3. Kaye, 1995, Am J Physiol, 269, H182
  4. Johansson, 1997, Am J Physiol, 273, H2178
  5. Eisenhofer, 1990, etab, 70, 1710
  6. Esler, 1995, J Clin Endocrinol Metab, 80, 435, 10.1210/jc.80.2.435 · DOI
  7. Kennedy, 1992, Am J Physiol, 258, L227

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Metadata

Authors
Rumantir, M. S., Jennings, G. L., Lambert, G. W., Kaye, D. M., Seals, D. R., & Esler, M. D.
Affiliations
  • The Alfred Hospital (AU)
  • University of Colorado Boulder (US)
Corresponding author
Rumantir, Magdalena S.
ORCID
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-06
Volume
18
Issue
6
Pages
717-723
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/00004872-200018060-00009
OpenAlex
W1965533587
Cited by
72
References
27
Citations by year
2023: 1 · 2022: 1 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 4 · 2013: 2 · 2012: 3
FWCI
4.71
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AGO6537, R01AG006537)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
essential hypertension, adrenaline secretion, cardiac sympathetic nerves, noradrenaline spillover, beta2-adrenergic receptor
MeSH terms
Adult, Epinephrine, Female, Heart Conduction System, Humans, Hypertension, Male, Middle Aged, Models, Cardiovascular, Myocardium, Norepinephrine, Reference Values, Sympathetic Nervous System

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