Seals, Douglas R.

Age-predicted maximal heart rate revisited

Tanaka, H., Monahan, K. D., & Seals, D. R. (2001) · Journal of the American College of Cardiology

Cardiovascular and exercise physiologyPhysical Activity and Health

Cited by 3,775

Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men

DeSouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., Tanaka, H., & Seals, D. R. (2000) · Circulation

Cardiovascular and exercise physiologyCardiovascular Health and Disease Prevention

Cited by 896

Aging and vascular endothelial function in humans

Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 725

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications

Sirtuins and Resveratrol in MedicineFolate and B Vitamins Research

Cited by 588

Effects of the cold pressor test on muscle sympathetic nerve activity in humans.

Victor, R. G., Leimbach, W. N., Seals, D. R., Wallin, B. G., & Mark, A. L. (1987) · Hypertension

Heart Rate Variability and Autonomic ControlBlood Pressure and Hypertension Studies

Cited by 519

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

Rossman, M. J., Santos-Parker, J. R., Steward, C. A. C., Bispham, N. Z., Cuevas, L. M., Rosenberg, H. L., Woodward, K. A., Chonchol, M., Gioscia-Ryan, R. A., Murphy, M. P., et al. (2018) · Hypertension

Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Cited by 456

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell

Sirtuins and Resveratrol in MedicineCardiovascular Health and Disease Prevention

Cited by 396

Neural mechanisms in human obesity-related hypertension

Rumantir, M. S., Vaz, M., Jennings, G. L., Collier, G., Kaye, D. M., Seals, D. R., Wiesner, G. H., Brunner-La Rocca, H. P., & Esler, M. D. (1999) · Journal of Hypertension

Blood Pressure and Hypertension StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 396

Effect of acute and chronic ascorbic acid on flow‐mediated dilatation with sedentary and physically active human ageing

Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R. (2004) · The Journal of Physiology

Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Cited by 341

Endurance training in older men and women. I. Cardiovascular responses to exercise

Seals, D. R., Hagberg, J. M., Hurley, B. F., Ehsani, A. A., & Holloszy, J. O. (1984) · Journal of Applied Physiology

Cardiovascular and exercise physiologyPhysical Activity and Health

Cited by 341

Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis

Fitzgerald, M. D., Tanaka, H., Tran, Z. V., & Seals, D. R. (1997) · Journal of Applied Physiology

Cardiovascular and exercise physiologyPhysical Activity and Health

Cited by 308

Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity

Tanaka, H., & Seals, D. R. (2003) · Journal of Applied Physiology

Cardiovascular and exercise physiologySports Performance and Training

Cited by 275

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

Gioscia‐Ryan, R. A., LaRocca, T. J., Sindler, A. L., Zigler, M. C., Murphy, M. P., & Seals, D. R. (2014) · The Journal of Physiology

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 263

Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

Pierce, G. L., Lesniewski, L. A., Lawson, B. R., Beske, S. D., & Seals, D. R. (2009) · Circulation

Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Cited by 262

Influence of lung volume on sympathetic nerve discharge in normal humans.

Seals, D. R., Suwarno, N. O., & Dempsey, J. A. (1990) · Circulation Research

Cardiovascular and exercise physiologyHeart Rate Variability and Autonomic Control

Cited by 246

Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

Donato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell

NF-κB Signaling PathwaysNitric Oxide and Endothelin Effects

Cited by 237

Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function

Rossman, M. J., Kaplon, R. E., Hill, S. D., McNamara, M. N., Santos-Parker, J. R., Pierce, G. L., Seals, D. R., & Donato, A. J. (2017) · American Journal of Physiology-Heart and Circulatory Physiology

Telomeres, Telomerase, and SenescenceCardiovascular Health and Disease Prevention

Cited by 232

Glucose tolerance in young and older athletes and sedentary men

Seals, D. R., Hagberg, J. M., Allen, W. K., Hurley, B. F., Dalsky, G. P., Ehsani, A. A., & Holloszy, J. O. (1984) · Journal of Applied Physiology

Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular and exercise physiology

Cited by 228

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging

Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell

Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Cited by 218

Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women

Tanaka, H., Desouza, C. A., Jones, P. P., Stevenson, E. T., Davy, K. P., & Seals, D. R. (1997) · Journal of Applied Physiology

Cardiovascular and exercise physiologyPhysical Activity and Health

Cited by 216

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

Brunt, V. E., LaRocca, T. J., Bazzoni, A. E., Sapinsley, Z. J., Miyamoto-Ditmon, J., Gioscia-Ryan, R. A., Neilson, A. P., Link, C. D., & Seals, D. R. (2021) · GeroScience

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 197

Effects of Aging on the Responsiveness of the Human Cardiac Sympathetic Nerves to Stressors

Esler, M. D., Thompson, J. M., Kaye, D. M., Turner, A. G., Jennings, G. L., Cox, H. S., Lambert, G. W., & Seals, D. R. (1995) · Circulation

Heart Rate Variability and Autonomic ControlCardiovascular and exercise physiology

Cited by 183

Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice

Brunt, V. E., Gioscia‐Ryan, R. A., Richey, J. J., Zigler, M. C., Cuevas, L. M., Gonzalez, A., Vázquez‐Baeza, Y., Battson, M. L., Smithson, A. T., Gilley, A. D., et al. (2019) · The Journal of Physiology

Gut microbiota and healthCardiovascular Health and Disease Prevention

Cited by 182

Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults

Martens, C. R., Rossman, M. J., Mazzo, M. R., Jankowski, L. R., Nagy, E. E., Denman, B. A., Richey, J. J., Johnson, S. A., Ziemba, B. P., Wang, Y., et al. (2020) · GeroScience

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 182