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Changes in Plasma Norepinephrine to Combat-Related Stimuli among Vietnam Veterans with Posttraumatic Stress Disorder

BLANCHARD, EDWARD B., KOLB, LAWRENCE C., PRINS, ANNABEL, GATES, SHERMAN, McCOY, GUY C.·1991·The Journal of Nervous and Mental Disease

DOI 10.1097/00005053-199106000-00012

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Abstract

Plasma norepinephrine samples were obtained before and after exposure to auditory stimuli reminiscent of combat from two groups of male Vietnam veterans with combat experience: one with diagnoses of PTSD (N = 15) and one with no mental disorder (N = 6). Results showed a significant 30% rise in plasma norepinephrine for the PTSD group, with no change in the comparison group.

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Background
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Background
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Background
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BackgroundResult
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Servatius, R. J., Ottenweller, J. E., Bergen, M. T., Soldan, S. A., & Natelson, B. H. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90328-x · Cited by 70
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Background
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“, 2018) and persistent changes in LC function have been observed following stress/trauma (Blanchard et al., 2012; George et al., 2013).”
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“001), while the same stimuli lead to no significant change in plasma NE in healthy controls [16].”
Background
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Background
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Influential
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Background
Integrating NIMH Research Domain Criteria (RDoC) into PTSD Research
Schmidt, U., & Vermetten, E. H. G. J. M. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_1 · Cited by 49
Exaggerated platelet reactivity to physiological agonists in war veterans with posttraumatic stress disorder
Vidović, A., Grubišić-Ilić, M., Kozarić‐Kovačić, D., Gotovac, K., Rakoš, I., Markotić, A., Rabatić, S., Dekaris, D., & Sabioncello, A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.08.005 · Cited by 41
“In addition, plasma NE/EPI responses to trauma-related stimuli were more pronounced in PTSD patients when compared to controls (McFall et al., 1990; Blanchard et al., 1991; Liberzon et al., 1999).”
Background
Abnormal Stimulus-Response Intensity Functions in Posttraumatic Stress Disorder: An Electrophysiological Investigation
Lewine, J. D., Thoma, R. J., PROVENCAL, S. L., Edgar, C. J., Miller, G. A., & Cañive, J. M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1689 · Cited by 40
Exploring the relationship between posttraumatic stress disorder symptoms and momentary heart rate variability
Green, K. T., Dennis, P. A., Neal, L. C., Hobkirk, A. L., Hicks, T. A., Watkins, L. L., Hayano, J., Sherwood, A., Calhoun, P. S., & Beckham, J. C. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.01.003 · Cited by 40
Psychophysiologic assessment of mental imagery of stressful events in israeli civilian posttraumatic stress disorder patients
Shalev, A. Y., Peri, T., Gelpin, E., Orr, S. P., & Pitman, R. K. (1997) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(97)90059-6 · Cited by 36
Sensory gating deficits, pattern completion, and disturbed fronto-limbic balance, a model for description of hallucinations and delusions in schizophrenia.
Javanbakht, A. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.03.054 · Cited by 38
“[43] Blanchard EB, Kolb LC, Prins A, Gates S, McCoy GC.”
Background
Posttraumatic Stress Disorder
Resick, P. A., Monson, C. M., & LoSavio, S. T. (2017) · Psychopathology · doi:10.1002/9781394258949.ch6 · Cited by 37
Rhythms dysregulation: A new perspective for understanding PTSD?
Dayan, J., Rauchs, G., & Guillery‐Girard, B. (2016) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2017.01.004 · Cited by 35
“individuals with and without PTSD (Blanchard et al., 1991; McFall et al., 1992; Pitman and Orr, 1990).”
Dysregulation of aversive signaling pathways: a novel circuit endophenotype for pain and anxiety disorders
Yeh, L.-F., Watanabe, M., Cuevas, J. N. S., & Johansen, J. P. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.006 · Cited by 31
Relevance of Neuroendocrine Alterations in PTSD to Memory-Related Impairments of Trauma Survivors
Yehuda, R., Harvey, P. D., & O’Carroll, R. E. (1997) · Springer eBooks · doi:10.1007/978-1-4757-2672-5_9 · Cited by 31
Neuroendocrine Alterations in Posttraumatic Stress Disorder
Southwick, S. M., Yehuda, R., & Wang, S. (1998) · Psychiatric Annals · doi:10.3928/0048-5713-19980801-07 · Cited by 29
Psychoneuroendocrine assessment of posttraumatic stress disorder: Current progress and new directions
Yehuda, R., Giller, E. L., & Mason, J. W. (1993) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(93)90004-c · Cited by 29
Concepts of Scientific Integrative Medicine Applied to the Physiology and Pathophysiology of Catecholamine Systems
Goldstein, D. S. (2013) · Comprehensive physiology · doi:10.1002/cphy.c130006 · Cited by 33
“In Vietnam veterans with PTSD, exposure to auditory combat-related stimuli was reported to increase plasma NE levels, a measure of SNS activation (18), and in PTSD urinary excretion rates of NE and EPI are chronically increased (185); however, cortisol levels are if anything decreased.”
Posttraumatic stress disorder and soluble cellular adhesion molecules at rest and in response to a trauma-specific interview in patients after myocardial infarction
von Känel, R., Abbas, C. C., Begré, S., Saner, H. E., Gander, M., & Schmid, J. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.06.005 · Cited by 27
“Patients with PTSD also showed exaggerated responses in heart rate, blood pressure, and catecholamines to trauma-specific stimuli (McFall et al., 1990; Blanchard et al., 1991; Bedi and Arora, 2007).”
Background
Anxiety Disorders: Noradrenergic Neurotransmission
Neumeister, A., Daher, R. J., & Charney, D. S. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-28082-0_8 · Cited by 28
Self-reported stressors, symptom complaints and psychobiological functioning II: Psychoneuroendocrine variables
Vingerhoets, A. J. J. M., Ratliff-Crain, J., Jabaaij, L., Tilders, F. J. H., Moleman, P., & Menges, L. J. (1996) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(95)00528-5 · Cited by 27
On making (and turning adaptive to) maladaptive aversive memories in laboratory rodents
Gazarini, L., Stern, C. A. J., & Bertoglio, L. J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105101 · Cited by 27
Repeated fear‐induced diurnal rhythm disruptions predict PTSD ‐like sensitized physiological acute stress responses in F 344 rats
Thompson, R. S., Strong, P. V., Clark, P., Maslanik, T., Wright, K., Greenwood, B. N., & Fleshner, M. (2014) · Acta Physiologica · doi:10.1111/apha.12239 · Cited by 27
“Published by John Wiley & Sons Ltd, doi: 10.1111/apha.12239 447 (Shalev et al. 1997, Rietsema 2003), as well as exaggerated hypothalamic–pituitary axis (HPA) responses in some cases (Blanchard et al. 1991, Heim et al. 2000, Morris et al. 2012).”
BackgroundInfluential
Neutrophil β 2 -adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls
Gurguis, G. N. M., Andrews, R., Antai-Otong, D., Vo, S. P., Blakeley, J. E., Orsulak, P. J., & Rush, A. J. (1999) · Psychopharmacology · doi:10.1007/s002130050928 · Cited by 24
“Psychophysiologic studies demonstrated increased heart rate, blood pressure, skin conductance and electromyographic responses to exposure to combat-related stimuli ( Blanchard et al. 1982, 1991; Kolb 1984, 1987; Pallmeyer et al. 1986; Pitman et al. 1987; McFall et al. 1990).”
Background
Abnormal ECG Patterns in Chronic Post-War PTSD Patients: A Pilot Study
Khazaie, H., Saidi, M. R., Sepehry, A. A., Knight, D. C., Ahmadi, M., Najafi, F., Fard, A. A. P., Samadzadeh, S., & Tahmasian, M. (2011) · International Journal of Behavioral Medicine · doi:10.1007/s12529-011-9197-y · Cited by 24
“Individuals suffering from PTSD and depression appear to be at risk of developing cardiovascular disorders [20, 21, 23, 25].”
BackgroundInfluential
The psychobiology of PTSD: Perspectives and reflections on the past, present, and future
Kolb, L. C. (1993) · Journal of Traumatic Stress · doi:10.1002/jts.2490060302 · Cited by 24
Self-citation
Endocrine and inflammatory alterations in post-traumatic stress disorder
Wessa, M., & Rohleder, N. (2006) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2.1.91 · Cited by 26
“…(n = 17) vs healthy controls (n = 10) medication free SCID 8 a.m. plasma after overnight fast Higher plasma NE in PTSD [95] Unchanged or lower in PTSD Blanchard et al., 1991 Cross-sectional study Vietnam veterans with PTSD (n = 15) vs Vietnam veterans without PTSD (combat controls; n = 6) DSM-IIIR…”
BackgroundMethod
Assessment of noradrenergic functioning in patients with noncombat-related posttraumatic stress disorder: a study with desmethylimipramine and orthostatic challenges
Yatham, L. N., Sacamano, J., & Kusumakar, V. (1996) · Psychiatry Research · doi:10.1016/0165-1781(96)02896-x · Cited by 22
Neuroendocrine and immune responses to a cognitive stress challenge in veterans with and without PTSD
de Kloet, C. S., Vermetten, E. H. G. J. M., Rademaker, A. R., Geuze, E., & Westenberg, H. M. (2012) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v3i0.16206 · Cited by 21
“Studies in PTSD have shown increased SNS responses to trauma related stimuli (Blanchard et al., 1991; Liberzon et al., 1999; McFall et al., 1990), and elevated salivary cortisol levels in anticipation, but not in response to traumatic scripts (Valentino, 1988), traumatic reminders (Liberzon et al.”
Background
Association Between Posttraumatic Stress Disorder Following Myocardial Infarction and Liver Enzyme Levels: A Prospective Study
von Känel, R., Abbas, C. C., Begré, S., Gander, M., Saner, H. E., & Schmid, J. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-1082-z · Cited by 22
“Moreover, military veterans with PTSD showed increased circulating levels of norepinephrine [39] and greater increase in plasma norepinephrine to trauma-specific stimuli [40].”
Background
Psychobiologische Aspekte der Posttraumatischen Belastungsstöung
Ehlert, U., Wagner, D., Heinrichs, M., & Heim, C. C. (1999) · Der Nervenarzt · doi:10.1007/s001150050511 · Cited by 21
Effects of posttraumatic stress disorder on cardiovascular stress responses in Gulf War veterans with fatiguing illness
Peckerman, A., Dahl, K., Chemitiganti, R., LaManca, J. J., Ottenweller, J. E., & Natelson, B. H. (2003) · Autonomic Neuroscience · doi:10.1016/s1566-0702(03)00155-3 · Cited by 19
“Autonomic changes in PTSD were reported to included an increase in sympathetic activity, as expressed in elevated plasma (Blanchard et al., 1991) and urinary (Yehuda et al.”
Background

Authors: BLANCHARD, E. B., KOLB, L. C., PRINS, A., GATES, S., & McCOY, G. C.
Affiliations: State University of New York (US)
Albany Medical College (US)
ORCID: PRINS, ANNABEL
Venue: The Journal of Nervous and Mental Disease
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1991-06
Volume: 179
Issue: 6
Pages: 371-373
ISSN: 0022-3018 (ISSN-L)
DOI: 10.1097/00005053-199106000-00012
OpenAlex: W1964972447
Cited by: 152
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 10 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 3
FWCI: 4.83
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Nervous and Mental Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH-37838)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Keywords: plasma norepinephrine, post-traumatic stress disorder, Vietnam War veterans, autonomic arousal, combat exposure
MeSH terms: Acoustic Stimulation, Adult, Diagnosis, Differential, Humans, Male, Memory, Norepinephrine, Posture, Stress Disorders, Post-Traumatic, Tape Recording, Veterans, Vietnam, Warfare

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Changes in Plasma Norepinephrine to Combat-Related Stimuli among Vietnam Veterans with Posttraumatic Stress Disorder

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