Altered Blood Coagulation in Patients With Posttraumatic Stress Disorder
Abstract
Objective Posttraumatic stress disorder (PTSD) has been associated with an increased cardiovascular risk, though the pathophysiologic mechanisms involved are elusive. A hypercoagulable state before occurrence of coronary thrombosis contributes to atherosclerosis development. We investigated whether PTSD would be associated with increased coagulation activity. Methods We measured resting plasma levels of clotting factor VII activity (FVII:C), FVIII:C, FXII:C, fibrinogen, and D-dimer in 14 otherwise healthy patients with PTSD and in 14 age- and gender-matched, trauma-exposed non-PTSD controls. Categorical and dimensional diagnoses of PTSD were made using the Clinician-Administered PTSD Scale (CAPS) interview. We also investigated to what extent the relationship between PTSD and coagulation measures would be confounded by demographics, cardiovascular risk factors, lifestyle variables, time since trauma, and mood. Results Coagulation factor levels did not significantly differ between patients with a categorical diagnosis of PTSD and controls while controlling for covariates. In all subjects, FVIII:C was predicted by hyperarousal severity (beta = 0.46, p = .014) independent of covariates and by overall PTSD symptom severity (beta = 0.38, p = .045); the latter association was of borderline significance when separately controlling for gender, smoking, exercise, and anxiety (p values Conclusions PTSD may elicit hypercoagulability, even at subthreshold levels, offering one psychobiolo…
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Chronic distress is associated with detrimental processes, including hypercoagulability, dyslipidemia, impaired glucose control, and increased inflammatory processes and impaired immune responses.
“Specifically, chronic distress is associated with detrimental processes, including hypercoagulability, dyslipidemia, 112-114 impaired glucose control, 115,116 and increased inflammatory processes and impaired immune responses. 95,117,118”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [114]
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- Authors
- von Känel, R., Hepp, U., Buddeberg, C., Keel, M., Mica, L., Aschbacher, K., & Schnyder, U.
- Affiliations
- University of Bern (CH)
- Venue
- Psychosomatic Medicine
- Published
- 2006-07
- Volume
- 68
- Issue
- 4
- Pages
- 598-604
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2013835629
- Cited by
- 86
- References
- 62
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 3 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 11 · 2015: 7 · 2014: 4 · 2013: 9 · 2012: 5
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- post-traumatic stress disorder, hypercoagulability, coagulation, coagulation factors, fibrinogen, D-dimer, hyperarousal, cardiovascular risk, atherosclerosis, trauma exposure, PTSD symptom severity, mood, coronary artery disease, myocardial infarction, stroke, hyperlipidemia, smoking, physical inactivity
- MeSH terms
- Adult, Age Factors, Alcohol Drinking, Arousal, Blood Coagulation Disorders, Blood Coagulation Factors, Blood Pressure, Cardiovascular Diseases, Factor VII, Factor VIII, Female, Fibrin Fibrinogen Degradation Products, Fibrinogen, Humans, Life Change Events, Male, Risk Factors, Sex Factors, Stress Disorders, Post-Traumatic, Exercise, Atherosclerosis
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