Cited by 46Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Senile Plaques in an Aged Western Lowland Gorilla.

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KIMURA, Nobuyuki, NAKAMURA, Shinichiro, GOTO, Naoaki, NARUSHIMA, Etsuo, HARA, Itsuko, SHICHIRI, Shigemi, SAITOU, Kazuo, NOSE, Masao +3 more·2001·Experimental Animals

Abstract

Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostaining for amyloid beta protein (A beta) and a half of A beta-positive-SPs were also immunoreactive for apolipoprotein E. Moreover, all SPs were immunoreactive for A beta 42 and A beta 43, but not for A beta 40. SPs also did not contain A beta precursor protein-positive structures. These findings suggested that SPs in this case were diffuse plaques. To our knowledge, this is the first report of SPs in the gorilla.

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  • Great apes accumulate Aβ in the brain, resulting in the development of amyloid plaques and CAA in aged animals.

    “Great apes accumulate Aβ in the brain, resulting in the development of amyloid plaques and CAA in aged animals [43, 44, 78, 112, 113, 124].”

    From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [78]

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Research works printed but not linked: 5

  1. Cras, P., Kawai, M., Lowery, D., Gonzalez, D.P., Greenberg, B., and Perry, G. 1991. Proc. Natl. Acad. Sci. USA. 88: 7552-7556.
  2. Gearing, M., Rebeck, G.W., Hyman, B.T., Tigges, J., and Mirra, S.S. 1994. Proc. Natl. Acad. Sci. USA. 91: 9382- 9386.
  3. Kosik, K.S., Joachim, C.L., and Selkoe, D.J. 1986. Proc. Natl. Acad. Sci. USA. 83: 4044-4048.
  4. Manetto, V., Perry, G., Tabaton, M., Mulvihill, P., Fried, V.A., Smith, H.T., Gambetti, P., and Autilio, G.L. 1988. Proc. Natl. Acad. Sci. USA. 85: 4501-4505.
  5. Wisniewski, H.M. and Terry, R.D. 1973. pp. 1-26.In: Zimmerman HM (ed) Progress in Neuropathology: Vol 2. Grune and Stratton, New York.

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Authors
KIMURA, N., NAKAMURA, S., GOTO, N., NARUSHIMA, E., HARA, I., SHICHIRI, S., SAITOU, K., NOSE, M., HAYASHI, T., KAWAMURA, S., & YOSHIKAWA, Y.
Affiliations
  • The University of Tokyo (JP)
  • Department of Veterinary Pathology, Nippon Veterinary and Animal Science University
  • Shin-nihon Kagaku, Tokyo Pathology Center
  • Animal Hospital, Ueno Zoological Gardens
Venue
Experimental Animals
Published
2001
Volume
50
Issue
1
Pages
77-81
ISSN
  • 0007-5124 (ISSN-L)
  • 1341-1357
  • 1881-7122
OpenAlex
W2012043866
Cited by
46
References
30
Citations by year
2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 7 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
0.40
Type
journal article
Language
en
Open access
Locations
  • EXPERIMENTAL ANIMALS (publishedVersion)
  • PubMed (publishedVersion)
Funders
RIKEN
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
amyloid plaques, western lowland gorilla, Gorilla gorilla gorilla, amyloid-beta, apolipoprotein E, diffuse plaques, cerebral cortex, Congo red staining
MeSH terms
Aging, Animals, Apolipoproteins E, Cerebral Cortex, Gorilla gorilla, Immunohistochemistry, Male, Amyloid beta-Peptides, Silver Staining, Plaque, Amyloid

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