Senile Plaques in an Aged Western Lowland Gorilla.
Open accessAbstract
Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostaining for amyloid beta protein (A beta) and a half of A beta-positive-SPs were also immunoreactive for apolipoprotein E. Moreover, all SPs were immunoreactive for A beta 42 and A beta 43, but not for A beta 40. SPs also did not contain A beta precursor protein-positive structures. These findings suggested that SPs in this case were diffuse plaques. To our knowledge, this is the first report of SPs in the gorilla.
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“Great apes accumulate Aβ in the brain, resulting in the development of amyloid plaques and CAA in aged animals [43, 44, 78, 112, 113, 124].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [78]
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- Authors
- KIMURA, N., NAKAMURA, S., GOTO, N., NARUSHIMA, E., HARA, I., SHICHIRI, S., SAITOU, K., NOSE, M., HAYASHI, T., KAWAMURA, S., & YOSHIKAWA, Y.
- Affiliations
- The University of Tokyo (JP)
- Department of Veterinary Pathology, Nippon Veterinary and Animal Science University
- Shin-nihon Kagaku, Tokyo Pathology Center
- Animal Hospital, Ueno Zoological Gardens
- Venue
- Experimental Animals
- Published
- 2001
- Volume
- 50
- Issue
- 1
- Pages
- 77-81
- ISSN
- 0007-5124 (ISSN-L)
- 1341-1357
- 1881-7122
- OpenAlex
- W2012043866
- Cited by
- 46
- References
- 30
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 7 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EXPERIMENTAL ANIMALS (publishedVersion)
- PubMed (publishedVersion)
- Funders
- RIKEN
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid plaques, western lowland gorilla, Gorilla gorilla gorilla, amyloid-beta, apolipoprotein E, diffuse plaques, cerebral cortex, Congo red staining
- MeSH terms
- Aging, Animals, Apolipoproteins E, Cerebral Cortex, Gorilla gorilla, Immunohistochemistry, Male, Amyloid beta-Peptides, Silver Staining, Plaque, Amyloid
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