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A Quantitative Study of the Pigmented Neurons in the Nuclei Locus Coeruleus and Subcoeruleus in Man as Related to Aging
Abstract
The nuclei of the locus coeruleus and subcoeruleus were examined in human brains from individuals of 14 to 87 years. Serial counts were performed on every tenth Nissl stained paraffin section of melanin containing cells within the entire length of these nuclei. After 63 years, the neuronal population in these nuclei decreased 40%. This significant decrease in cell number is the first reported for a brain stem structure. In view of the relation of these noradrenaline containing cells to the catecholaminergic system and the widespread projections between these nuclei and other central nervous system structures, this decrease may be a factor in alteration of some central nervous system activities with increasing age.
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Cited by
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772
Mather, M., Clewett, D., Sakaki, M., & Harley, C. W. (2016) · Behavioral and Brain Sciences · doi:10.1017/s0140525x15000667 · Cited by 695
Pathology of Parkinson’s disease: Changes other than the nigrostriatal pathway
Jellinger, K. A. (1991) · Molecular and Chemical Neuropathology · doi:10.1007/bf03159935 · Cited by 684
Catecholamine regulation of the prefrontal cortex
Arnsten, A. F. T. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100208 · Cited by 488
Metadata
- Authors
- Vijayashankar, N., & Brody, H.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1979-09
- Volume
- 38
- Issue
- 5
- Pages
- 490-497
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W2031831762
- Cited by
- 298
- References
- 0
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Quantitative Study of the Pigmented Neurons in the Nuclei Locus Coeruleus and Subcoeruleus in Man as Related to Aging. https://app.cochat.ai/papers/10.1097/00005072-197909000-00004
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- Vijayashankar, N., & Brody, H. (1979). A Quantitative Study of the Pigmented Neurons in the Nuclei Locus Coeruleus and Subcoeruleus in Man as Related to Aging. Journal of Neuropathology & Experimental Neurology. https://doi.org/10.1097/00005072-197909000-00004
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
