The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Erythromycin Reduces Delayed Gastric Emptying in Critically Ill Trauma Patients: A Randomized, Controlled Trial
Abstract
Background Early enteral feeding has been shown to be beneficial in improving outcome in critically injured trauma patients. Delayed gastric emptying occurs frequently in trauma patients, increasing the time to achieve nutritional goals, and limiting the benefit of early enteral feedings. Intravenous erythromycin is an effective agent for improving gastric motility in diabetics and postgastrectomy patients. The purpose of this study is to determine the effectiveness of erythromycin for improving gastric motility in critically injured trauma patients. Methods All critically injured patients who received gastric feedings within 72 hours of admission were candidates for the study. Those patients who failed to tolerate feedings at 48 hours (gastric residual > 150 mL) were eligible for enrollment. Patients were prospectively assigned to two treatment groups by randomization to receive either erythromycin (ERY) or placebo (PLA). Treatment was continued in patients who tolerated gastric feedings until the feedings were no longer required. Patients with continued intolerance for 48 hours after randomization were considered failures of therapy and given metoclopramide. Results Sixty-eight patients were enrolled and were well matched for age, sex, and Injury Severity Score. Mortality, intensive care unit length of stay, hospital length of stay, number of ventilator days, and rate of nosocomial infections were similar in each group. There was a significant difference between the ERY gro…
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“According to our meta-analysis (see Meta-analysis V in Supplemental Materials), prokinetic use is associated with a trend towards better enteral feeding tolerance (RR 0.65, CI 0.37, 1.14, p=0.14).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [106]
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Erythromycin improves gastric emptying in critically ill patients intolerant of nasogastric feeding
Chapman, M. J., Fraser, R. J., Kluger, M. T., Buist, M. D., & De Nichilo, D. J. (2000) · Critical Care Medicine · doi:10.1097/00003246-200007000-00026 · Cited by 163
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McClave, S. A., Taylor, B. E., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115621863 · Cited by 3,982
ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904
McClave, S. A., Martindale, R. G., Vanek, V. W., McCarthy, M., Roberts, P., Taylor, B., Ochoa, J. B., Napolitano, L., Cresci, G., the A.S.P.E.N. Board of Directors, et al. (2009) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607109335234 · Cited by 1,873
Taylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476
ESPEN guidelines on enteral nutrition: intensive care
Kreymann, K. G., Berger, M. M., Deutz, N. E. P., Hiesmayr, M., Jolliet, P., Kazandjiev, G., Nitenberg, G., van den Berghe, G., Wernerman, J., Ebner, C., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.021 · Cited by 1,366
Metadata
- Authors
- Berne, J. D., Norwood, S. H., McAuley, C. E., Vallina, V. L., Villareal, D., Weston, J., & McClarty, J.
- Affiliations
- Eastern Association for the Surgery of Trauma (US)
- ORCID
- Weston, Jaye
- Venue
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2002-09
- Volume
- 53
- Issue
- 3
- Pages
- 422-425
- ISSN
- 0022-5282 (ISSN-L)
- OpenAlex
- W2075103253
- Cited by
- 112
- References
- 1
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 6 · 2013: 1 · 2012: 5
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Trauma: Injury, Infection, and Critical Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- erythromycin, delayed gastric emptying, gastric motility, early enteral nutrition, gastric residual volume, feeding intolerance, metoclopramide, ICU length of stay, nosocomial infections
- MeSH terms
- Adult, Anti-Bacterial Agents, Critical Care, Enteral Nutrition, Erythromycin, Female, Gastric Emptying, Humans, Infusions, Intravenous, Length of Stay, Male, Prospective Studies, Wounds, Penetrating, Injury Severity Score, Critical Illness, Treatment Outcome
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