Physical activity and the presence and extent of calcified coronary atherosclerosis
Abstract
Purpose Regular physical activity leads to a more favorable cardiovascular risk factor profile and a lower risk of developing incident coronary heart disease (CHD). These correlations suggest that higher levels of physical activity should also attenuate the presence and extent of coronary atherosclerosis. Methods Physical activity was measured using the Baecke Physical Activity Index in 630 consecutive asymptomatic men and women ages 39-45 without known heart disease. The degree of physical activity was compared with the cardiovascular risk factor profile and the presence and extent of subclinical atherosclerosis measured using electron beam computed tomography. Results Sports-related physical activity was associated with lower body mass index (r = -0.11; P = 0.001), higher high-density lipoprotein (HDL) cholesterol (r = 0.13; P = 0.003) and less glucose resistance as assessed by fasting serum insulin levels (r = -0.16; P = 0.001). Leisure-time and work-related physical activity were unrelated to any coronary risk variables. Calcified subclinical atherosclerosis was unrelated to all physical activity dimensions. Comparing the most sedentary (lowest quartile) and most active (highest quartile) patients, the prevalence of coronary calcium (17.0% vs 18.5%; P = 0.92) and mean coronary calcium scores (8 +/- 31 vs 5 +/- 15; P = 0.87) were similar. In a multivariate model controlling for standard cardiovascular risk factors and physical activity level, only low-density lipoprotein (…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other observational studies found either no association or an inverse relationship between physical activity or fitness and CAC.
“other observational studies that found either no association 14-16 or an inverse relationship 17, 18 between physical activity or fitness and CAC”
From Relationship between lifelong exercise volume and coronary atherosclerosis in athletes. (2017) · cites this paper as [15]
Cited by
Sorted by citations
Relationship between lifelong exercise volume and coronary atherosclerosis in athletes.
Aengevaeren, V. L., Mosterd, A., Braber, T. L., Prakken, N. H. J., Doevendans, P. A., Grobbee, D. E., Thompson, P. D., Eijsvogels, T. M. H., & Velthuis, B. K. (2017) · Circulation · doi:10.1161/circulationaha.117.027834 · Cited by 309 · see citing works
Aengevaeren, V. L., Mosterd, A., Sharma, S., Prakken, N. H. J., Möhlenkamp, S., Thompson, P. D., Velthuis, B. K., & Eijsvogels, T. M. H. (2020) · Circulation · doi:10.1161/circulationaha.119.044467 · Cited by 165 · see citing works
Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?
Wilund, K. R. (2007) · Clinical Science · doi:10.1042/cs20060368 · Cited by 138 · see citing works
Delaney, J. A. C., Jensky, N. E., Criqui, M. H., Whitt-Glover, M. C., Lima, J. A. C., & Allison, M. A. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.07.045 · Cited by 73 · see citing works
GERMAN, C. A., FANNING, J., SINGLETON, M. J., SHAPIRO, M. D., BRUBAKER, P. H., BERTONI, A. G., & YEBOAH, J. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002856 · Cited by 23 · see citing works
Cardiorespiratory fitness and coronary artery calcification in women
DeFina, L., Radford, N., Leonard, D., Gibbons, L., & Khera, A. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.01.016 · Cited by 21 · see citing works
Promoting physical activity amongst adolescent girls
Standiford Brown, A. (2009) · Issues in Comprehensive Pediatric Nursing · doi:10.1080/01460860902737400 · Cited by 18 · see citing works
- Authors
- TAYLOR, A. J., WATKINS, T., BELL, D., CARROW, J., BINDEMAN, J., SCHERR, D., FEUERSTEIN, I., WONG, H., BHATTARAI, S., VAITKUS, M., & O???MALLEY, P. G.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- ORCID
- FEUERSTEIN, IRWIN
- Venue
- Medicine and Science in Sports and Exercise
- Published
- 2002-02
- Volume
- 34
- Issue
- 2
- Pages
- 228-233
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2088183302
- Cited by
- 48
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- physical activity, coronary artery calcification, subclinical atherosclerosis, coronary heart disease risk, cardiovascular risk factors, body mass index, HDL cholesterol, insulin resistance, LDL cholesterol, coronary artery calcium score, sedentary behavior, leisure-time physical activity, work-related physical activity
- MeSH terms
- Adult, Anthropometry, Blood Pressure, Calcinosis, Cholesterol, Coronary Artery Disease, Female, Humans, Insulin, Male, Middle Aged, Risk Factors, Sports, Statistics as Topic, Tomography, X-Ray Computed, United States, Exercise, Prevalence, Sex Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
