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Cited by 532

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

CD8+ Tumor-Infiltrating Lymphocytes Together with CD4+ Tumor-Infiltrating Lymphocytes and Dendritic Cells Improve the Prognosis of Patients with Pancreatic Adenocarcinoma

Fukunaga, Akira, Miyamoto, Masaki, Cho, Yasushi, Murakami, Soichi, Kawarada, You, Oshikiri, Taro, Kato, Kentaro, Kurokawa, Takanori, Suzuoki, Masato, Nakakubo, Yoshihiro, Hiraoka, Kei, Itoh, Tomoo, Morikawa, Toshiaki, Okushiba, Shunichi, Kondo, Satoshi, Katoh, Hiroyuki·2004·Pancreas
DOI 10.1097/00006676-200401000-00023
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Abstract

OBJECTIVE: Recent studies have demonstrated the importance of tumor immunity for a cancer patient's prognosis. In some types of cancer, it has been shown through immunohistochemical analysis that the existence of CD8+ tumor-infiltrating lymphocytes (TILs) is a crucial factor in determining prognosis. In an experimental model, CD4+ lymphocytes together with CD8+ lymphocytes contributed significantly to tumor immunity. METHODS: Specimens were taken from 80 surgically resected pancreatic adenocarcinomas between 1992 and 1999. Immunohistochemical staining of CD4, CD8, and S100 protein was performed, and the levels of these proteins were determined by microscopic analysis. The percentages of patients in the CD4(+) and CD8(+) groups were 59% (47/80) and 25% (16/80), respectively. When separated into 4 groups, CD4/8(+/+), CD4/8(+/-), CD4/8(-/+) and CD4/8(-/-), the overall survival rate was significantly higher in CD4/8(+/+) patients (13 cases) compared with those in all other groups combined (67 cases; P = 0.0098). CD4/8(+/+) status was negatively correlated with tumor depth and TNM stage. Multivariate analyses showed that CD4/8(+/+) status was an independent favorable prognostic factor. The number of tumor-infiltrating S100 protein positive cells was also significantly higher in the CD4/8(+/+) group than in others (P = 0.0084). CONCLUSIONS: In pancreatic adenocarcinoma, the presence of CD4+ TILs together with CD8+ TILs serves as a good indicator of the patient's outcome after surgical treatment.

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Metadata

Authors
Fukunaga, A., Miyamoto, M., Cho, Y., Murakami, S., Kawarada, Y., Oshikiri, T., Kato, K., Kurokawa, T., Suzuoki, M., Nakakubo, Y., Hiraoka, K., Itoh, T., Morikawa, T., Okushiba, S., Kondo, S., & Katoh, H.
Venue
Pancreas
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-01
Volume
28
Issue
1
Pages
e26-e31
ISSN
0885-3177 (ISSN-L)
DOI
10.1097/00006676-200401000-00023
OpenAlex
W2079548788
Cited by
532
References
15
FWCI
1.94
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: CD8+ Tumor-Infiltrating Lymphocytes Together with CD4+ Tumor-Infiltrating Lymphocytes and Dendritic Cells Improve the Prognosis of Patients with Pancreatic Adenocarcinoma. https://app.cochat.ai/papers/10.1097/00006676-200401000-00023
The paper
Fukunaga, A., Miyamoto, M., Cho, Y., Murakami, S., Kawarada, Y., Oshikiri, T., Kato, K., Kurokawa, T., Suzuoki, M., Nakakubo, Y., Hiraoka, K., Itoh, T., Morikawa, T., Okushiba, S., Kondo, S., & Katoh, H. (2004). CD8+ Tumor-Infiltrating Lymphocytes Together with CD4+ Tumor-Infiltrating Lymphocytes and Dendritic Cells Improve the Prognosis of Patients with Pancreatic Adenocarcinoma. Pancreas. https://doi.org/10.1097/00006676-200401000-00023

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.