Cited by 394Sexual function and dysfunction studiesHormonal and reproductive studiesMenopause: Health Impacts and Treatments

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The role of androgen in the maintenance of sexual functioning in oophorectomized women.

Sherwin, B B, Gelfand, M M·1987·Psychosomatic Medicine

DOI 10.1097/00006842-198707000-00009

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Abstract

Five aspects of sexual behavior were monitored daily in three groups of women who had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy approximately 4 years ago for benign disease. One group had been receiving an estrogen-androgen preparation intramuscularly once a month since their surgery (E-A). The second group had been receiving estrogen alone (E) and the third group of women had remained untreated. Plasma estradiol and testosterone were measured at an established baseline and again on days 2, 4, 8, 15, 21, and 28 postinjection. Women who received both sex steroids reported higher rates of sexual desire (p less than 0.01), sexual arousal (p less than 0.01), and numbers of fantasies (p less than 0.01) than those who were either given E or who were untreated. Moreover, changes in these behaviors covaried with plasma testosterone but not with plasma estradiol levels during the treatment month as the drug was being metabolized. Rates of coitus and orgasm were also higher in the E-A group during the first two postinjection weeks (p less than 0.01) coincident with their higher testosterone levels. These findings imply that androgen may be critical for the maintenance of optimal levels of sexual functioning in postmenopausal women.

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Untitled work
(2000) · doi:10.1002/1099-1611(200011/12)9:6

Authors: Sherwin, B. B., & Gelfand, M. M.
Venue: Psychosomatic Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1987-07
Volume: 49
Issue: 4
Pages: 397-409
ISSN: 0033-3174 (ISSN-L)
DOI: 10.1097/00006842-198707000-00009
OpenAlex: W1971903129
Cited by: 394
References: 0
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 5 · 2012: 8
FWCI: 14.84
Type: journal article
Language: en
Open access: closed
Locations: Psychosomatic Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: androgens, testosterone, sexual function, postmenopausal women, oophorectomy, hysterectomy, sexual desire, sexual arousal, sexual fantasies, sexual intercourse, orgasm, estradiol, hormone replacement therapy
MeSH terms: Adult, Estradiol, Female, Humans, Hysterectomy, Menopause, Premature, Middle Aged, Ovariectomy, Sexual Behavior, Testosterone

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The role of androgen in the maintenance of sexual functioning in oophorectomized women.

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