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The role of androgen in the maintenance of sexual functioning in oophorectomized women.
Abstract
Five aspects of sexual behavior were monitored daily in three groups of women who had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy approximately 4 years ago for benign disease. One group had been receiving an estrogen-androgen preparation intramuscularly once a month since their surgery (E-A). The second group had been receiving estrogen alone (E) and the third group of women had remained untreated. Plasma estradiol and testosterone were measured at an established baseline and again on days 2, 4, 8, 15, 21, and 28 postinjection. Women who received both sex steroids reported higher rates of sexual desire (p less than 0.01), sexual arousal (p less than 0.01), and numbers of fantasies (p less than 0.01) than those who were either given E or who were untreated. Moreover, changes in these behaviors covaried with plasma testosterone but not with plasma estradiol levels during the treatment month as the drug was being metabolized. Rates of coitus and orgasm were also higher in the E-A group during the first two postinjection weeks (p less than 0.01) coincident with their higher testosterone levels. These findings imply that androgen may be critical for the maintenance of optimal levels of sexual functioning in postmenopausal women.
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“By heightening sexual desire in the less aroused partner (by using testosterone, for instance, see Braunstein et al. 2005; Sherwin 2002; Sherwin and Gelfand 1987; Sherwin et al. 1985) or reducing it in the more aroused partner, the discrepancy could be minimized, possibly softening a major source of relationship strain.”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Sherwin and Gelfand 1987
In the citing paper
“Evidence of 'tolerance' developing to supra-physiological levels of testosterone was reported in several of the hormone replacement studies reviewed earlier (e.g.Brincat et al. 1984, Sherwin & Gelfand 1987).”
From The endocrinology of sexual arousal (2005) · cites this paper as Sherwin & Gelfand 1987
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BackgroundThe influence of testosterone on human aggression
Archer, J. E. (1991) · British Journal of Psychology · doi:10.1111/j.2044-8295.1991.tb02379.x · Cited by 656
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ResultLabrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544
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Simon, J., Braunstein, G., Nachtigall, L., Utian, W., Katz, M., Miller, S., Waldbaum, A., Bouchard, C., Derzko, C., Buch, A., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1747 · Cited by 475
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“[1–10]).”
Gender differences in behaviour: Activating effects of cross-sex hormones
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Labrie, F., Diamond, P., Cusan, L., Gomez, J.-L., Bélanger, A., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4306 · Cited by 292
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Sherwin, B. B. (1988) · Journal of Affective Disorders · doi:10.1016/0165-0327(88)90061-4 · Cited by 258
Self-citationDavis, S. R., van der Mooren, M. J., van Lunsen, R. H. W., Lopes, P., Ribot, J., Rees, M., Moufarege, A., Rodenberg, C., Buch, A., & Purdie, D. W. (2006) · Menopause · doi:10.1097/01.gme.0000179049.08371.c7 · Cited by 250
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Böös, J. N., von Schoultz, B., & Carlström, K. (1993) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/01674829309084451 · Cited by 188
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“…of an estrogen therapy at increasing sexual desire in postmenopausal women (Burger et al., 1987; Flöter et al., 2002; Sherwin et al., 1985; Sherwin & Gelfand, 1987; Braunstein et al., 2005; Buster et al., 2005; Davis et al., 2006b; Panay et al., 2010; Shifren et al., 2006; Simon et al.,…”
BackgroundMethodInfluentialDobs, A. S., Nguyen, T., Pace, C., & Roberts, C. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8362 · Cited by 168
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Achilli, C., Pundir, J., Ramanathan, P., Sabatini, L., Hamoda, H., & Panay, N. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.10.028 · Cited by 148
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Sexuality in sexagenarian women
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Halpern, C. T., Udry, J. R., & Suchindran, C. (1997) · Psychosomatic Medicine · doi:10.1097/00006842-199703000-00008 · Cited by 124
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Berman, J. R., Adhikari, S. P., & Goldstein, I. (2000) · European Urology · doi:10.1159/000020247 · Cited by 124
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Kaplan, H. S. (1992) · Journal of Sex & Marital Therapy · doi:10.1080/00926239208404354 · Cited by 114
Neuroenhancement of love and marriage: the chemicals between us.
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Parker, W. H. (2010) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2009.12.016 · Cited by 110
Effects of Hormone Replacement Therapy on Sexual Psychophysiology and Behavior in Postmenopause
Sarrel, P. M. (2000) · Journal of Women s Health & Gender-Based Medicine · doi:10.1089/152460900318830 · Cited by 109
Pearce, J., Hawton, K., & Blake, F. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.167.2.163 · Cited by 105
Androgens and Women at the Menopause and Beyond
Morley, J. E., & Perry, H. M. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.5.m409 · Cited by 98
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Bancroft, J., Sherwin, B. B., Alexander, G. M., Davidson, D. W., & Walker, A. (1991) · Archives of Sexual Behavior · doi:10.1007/bf01541939 · Cited by 102
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BackgroundInfluentialSelf-citationBlaustein, J. D. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093556 · Cited by 101
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Caruso, S., Agnello, C., Malandrino, C., Presti, L. L., Cicero, C., & Cianci, S. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12348 · Cited by 97
Safety of testosterone treatment in postmenopausal women
Braunstein, G. D. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.118 · Cited by 99
Menopause and hormone replacement therapy: An overview
HAMMOND, C. (1996) · Obstetrics and Gynecology · doi:10.1016/0029-7844(95)00429-7 · Cited by 98
Mate selection: Economics and affection
Wallen, K. (1989) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00024250 · Cited by 96
Tohgi, H., Utsugisawa, K., Yamagata, M., & Yoshimura, M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00971-r · Cited by 96
Hypoactive sexual desire disorder: An overview.
Beck, J. G. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.63.6.919 · Cited by 96
Aziz, A., Brännström, M., Bergquist, C., & Silfverstolpe, G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.12.008 · Cited by 94
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BackgroundLabrie, F., Derogatis, L. R., Archer, D. F., Koltun, W. D., Vachon, A., Young, D. G., Frenette, L., Portman, D. J., Montesino, M., Côté, I., et al. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.13045 · Cited by 94
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Schaffir, J. (2006) · Journal of Sex & Marital Therapy · doi:10.1080/00926230600666311 · Cited by 95
Behavioural correlates of testosterone
Christiansen, K. (1998) · Springer eBooks · doi:10.1007/978-3-642-72185-4_3 · Cited by 90
Finch, A., Evans, D. G., & Narod, S. A. (2012) · Women s Health · doi:10.2217/whe.12.41 · Cited by 91
“Androgen replacement therapy may be helpful here [8,92–94].”
BackgroundDavis, S. R., Goldstat, R., Papalia, M.-A., Shah, S., Kulkarni, J., Donath, S. M., & Bell, R. J. (2006) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000168061.32917.83 · Cited by 90
Breast cancer, menopause, and long-term survivorship: critical issues for the 21st century
Ganz, P. A. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.09.047 · Cited by 89
Graziottin, A. (2000) · Maturitas · doi:10.1016/s0378-5122(99)00072-9 · Cited by 87
“after surgical menopause) [24,30,31] but it seems not to affect sexual arousal and behaviour in naturally menopausal women”
BackgroundBiological factors in human sexuality
Bancroft, J. (2002) · The Journal of Sex Research · doi:10.1080/00224490209552114 · Cited by 91
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Bolour, S. Y., & Braunstein, G. D. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901334 · Cited by 89
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Motta‐Mena, N. V., & Puts, D. A. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.012 · Cited by 89
“Although no studies of which we are aware have explored which hormones drive any cyclic changes in orgasm, treatment studies indicate that testosterone (Buster et al., 2005; Sherwin and Gelfand, 1987) and estradiol (Dennerstein et al., 1980) increase women's frequency of experiencing orgasm.”
BackgroundTestosterone and sexual behavior in oral contraceptive users and nonusers: a prospective study.
Alexander, G. M., Sherwin, B., Bancroft, J., & Davidson, D. (1990) · Hormones and Behavior · doi:10.1016/0018-506x(90)90017-r · Cited by 93
Sherwin, B. B. (1988) · Psychobiology · doi:10.3758/bf03327339 · Cited by 86
Self-citationEffects of ovariectomy and steroid hormones on vaginal smooth muscle contractility
Kim, N. N., Min, K. S., Pessina, M. A., Munarriz, R. M., Goldstein, I., & Traish, A. M. (2004) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901138 · Cited by 85
Kotsopoulos, J., & Narod, S. A. (2011) · Steroids · doi:10.1016/j.steroids.2011.10.002 · Cited by 85
Gender Differences in Sexual Interest
Baldwin, J. D., & Baldwin, J. I. (1997) · Archives of Sexual Behavior · doi:10.1023/a:1024510528405 · Cited by 84
Harden, K. P. (2013) · Psychological Bulletin · doi:10.1037/a0033564 · Cited by 88
“In adult females, testosterone administration also produces increases in sexual motivation, even though mean levels of testosterone are still much lower compared to adult males (Burger, Hailes, & Nelson, 1987; Sherwin, 1988; Sherwin & Gelfand, 1987; Sherwin, Gelfand, & Brender, 1985).”
BackgroundSexual effects of androgens in women: some theoretical considerations
Bancroft, J. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02961-8 · Cited by 79
Testosterone Deficiency and Mood in Aging Men: Pathogenic and Therapeutic Interactions
Seidman, S. N. (2003) · The World Journal of Biological Psychiatry · doi:10.3109/15622970309167905 · Cited by 79
Female sexual dysfunction in postmenopausal women: Systematic review of placebo-controlled trials
Modelska, K., & Cummings, S. R. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.117 · Cited by 76
Menopause: evidence-based practice
Blake, J. M. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2006.07.001 · Cited by 79
Fry, A. M., Busby‐Earle, C., Rush, R., & Cull, A. (2001) · Psycho-Oncology · doi:10.1002/pon.512 · Cited by 76
“It is suggested that effects on sexual functioning are not reduced by oestrogen alone, but may be helped by the addition of androgen therapy (Sherwin and Gelfand, 1987; Bellerose and Binik, 1993).”
BackgroundThe psychology of human mate preferences
Symons, D. (1989) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00024225 · Cited by 75
Estradiol Increases Female Sexual Initiation Independent of Male Responsiveness in Rhesus Monkeys
Zehr, J. L., Dario Maestripieri, A., & Wallen, K. (1998) · Hormones and Behavior · doi:10.1006/hbeh.1998.1440 · Cited by 74
Bilateral oophorectomy and premature menopause
Hendrix, S. L. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.09.056 · Cited by 73
Elective oophorectomy for benign gynecological disorders
Shoupe, D., Parker, W. H., Broder, M. S., Liu, Z., Farquhar, C. M., & Berek, J. S. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31803c56a4 · Cited by 72
“with women who retain their ovaries.(68) Adverse changes in libido and orgasmic response may be more likely in”
BackgroundThe Role of Androgens in Female Sexual Dysfunction
Shifren, J. L. (2004) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(19)30668-8 · Cited by 73
Sex hormones and psychological functioning in postmenopausal women
Sherwin, B. B. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90021-3 · Cited by 72
Self-citationThe female androgen deficiency syndrome
Kaplan, H. S., & Owett, T. (1993) · Journal of Sex & Marital Therapy · doi:10.1080/00926239308404885 · Cited by 72
Metadata
- Authors
- Sherwin, B. B., & Gelfand, M. M.
- Venue
- Psychosomatic Medicine
- Published
- 1987-07
- Volume
- 49
- Issue
- 4
- Pages
- 397-409
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W1971903129
- Cited by
- 394
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 5 · 2012: 8
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- androgens, testosterone, sexual function, postmenopausal women, oophorectomy, hysterectomy, sexual desire, sexual arousal, sexual fantasies, sexual intercourse, orgasm, estradiol, hormone replacement therapy
- MeSH terms
- Adult, Estradiol, Female, Humans, Hysterectomy, Menopause, Premature, Middle Aged, Ovariectomy, Sexual Behavior, Testosterone
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