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The role of androgen in the maintenance of sexual functioning in oophorectomized women.
Abstract
Five aspects of sexual behavior were monitored daily in three groups of women who had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy approximately 4 years ago for benign disease. One group had been receiving an estrogen-androgen preparation intramuscularly once a month since their surgery (E-A). The second group had been receiving estrogen alone (E) and the third group of women had remained untreated. Plasma estradiol and testosterone were measured at an established baseline and again on days 2, 4, 8, 15, 21, and 28 postinjection. Women who received both sex steroids reported higher rates of sexual desire (p less than 0.01), sexual arousal (p less than 0.01), and numbers of fantasies (p less than 0.01) than those who were either given E or who were untreated. Moreover, changes in these behaviors covaried with plasma testosterone but not with plasma estradiol levels during the treatment month as the drug was being metabolized. Rates of coitus and orgasm were also higher in the E-A group during the first two postinjection weeks (p less than 0.01) coincident with their higher testosterone levels. These findings imply that androgen may be critical for the maintenance of optimal levels of sexual functioning in postmenopausal women.
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“By heightening sexual desire in the less aroused partner (by using testosterone, for instance, see Braunstein et al. 2005; Sherwin 2002; Sherwin and Gelfand 1987; Sherwin et al. 1985) or reducing it in the more aroused partner, the discrepancy could be minimized, possibly softening a major source of relationship strain.”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Sherwin and Gelfand 1987
In the citing paper
“Evidence of 'tolerance' developing to supra-physiological levels of testosterone was reported in several of the hormone replacement studies reviewed earlier (e.g.Brincat et al. 1984, Sherwin & Gelfand 1987).”
From The endocrinology of sexual arousal (2005) · cites this paper as Sherwin & Gelfand 1987
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Diamond, M. P., Legro, R. S., Coutifaris, C., Alvero, R. J., Robinson, R. D., Casson, P. R., Christman, G. M., Huang, H., Hansen, K. R., Baker, V. L., et al. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.04.034 · Cited by 34
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“The testosterone levels in studies by Sherwin et al. (1985) and Sherwin and Gelfand (1987) were supraphysiological.”
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“…in sexual interest; however, the precipitous drop in sexual interest in ovariectomized women (and its restoration with combined estradiol and testosterone therapy) demonstrates the central role of sex steroid hormones in female sexual motivation (Sherwin and Gelfand, 1987; Sherwin et al., 1985).”
BackgroundEffect of raloxifene on sexual function in postmenopausal women
Kessel, B., Nachtigall, L. E., Plouffe, L., Siddhanti, S. R., Rosen, A. S., & Parsons, A. (2003) · Climacteric · doi:10.1080/713605400 · Cited by 29
Burger, H., & Papalia, M.-A. (2006) · Sexual Health · doi:10.1071/sh05055 · Cited by 31
Cm, B., Wood, J. E., Wilkie, D., & DIXON, B. K. (2008) · PubMed · Cited by 29
Fernandes, C. E., Neto, J. S. D. L. P., Gebara, O., Filho, R. D. D. S., Neto, A. M. P., Filho, A. S. P., Athayde, A., Sposito, A. C., FERRARI, A., Albergaria, B., et al. (2008) · Americanae (AECID Library) · Cited by 29
Apperloo, M. J. A., Midden, M., van der Stege, J. G., Wouda, J. C., Hoek, A., & Schultz, W. C. M. W. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00212.x · Cited by 29
Metadata
- Authors
- Sherwin, B. B., & Gelfand, M. M.
- Venue
- Psychosomatic Medicine
- Published
- 1987-07
- Volume
- 49
- Issue
- 4
- Pages
- 397-409
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W1971903129
- Cited by
- 394
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 5 · 2012: 8
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- androgens, testosterone, sexual function, postmenopausal women, oophorectomy, hysterectomy, sexual desire, sexual arousal, sexual fantasies, sexual intercourse, orgasm, estradiol, hormone replacement therapy
- MeSH terms
- Adult, Estradiol, Female, Humans, Hysterectomy, Menopause, Premature, Middle Aged, Ovariectomy, Sexual Behavior, Testosterone
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