The DOI matches its Crossref record; 27 of the 30 references it cites were found in a registry or an index.
Psychological Stress, Cytokine Production, and Severity of Upper Respiratory Illness
Open accessAbstract
OBJECTIVE: The purpose of this study is to assess the role of psychological stress in the expression of illness among infected subjects and to test the plausibility of local proinflammatory cytokine production as a pathway linking stress to illness. METHODS: After completing a measure of psychological stress, 55 subjects were experimentally infected with an influenza A virus. Subjects were monitored in quarantine daily for upper respiratory symptoms, mucus production, and nasal lavage levels of interleukin (IL)-6. RESULTS: Higher psychological stress assessed before the viral challenge was associated with greater symptom scores, greater mucus weights, and higher IL-6 lavage concentrations in response to infection. The IL-6 response was temporally related to the two markers of illness severity, and mediation analyses indicated that these data were consistent with IL-6 acting as a major pathway through which stress was associated with increased symptoms of illness. However, this pattern of data is also consistent with increases in IL-6 occurring in response to tissue damage associated with illness symptoms. CONCLUSIONS: Psychological stress predicts a greater expression of illness and an increased production of IL-6 in response to an upper respiratory infection.
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“A series of studies have shown that chronic stress is associated with increased susceptibility to developing a common cold among persons experimentally exposed to an upper respiratory virus (e.g., refs.[14][15][16][17].”
From Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk (2012) · cites this paper as [16]
In the citing paper
“there is evidence consistent with stress effects resulting in increased disease risk because of their association with exaggerated local (in the nose) release of inflammatory cytokines (16).”
From Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk (2012) · cites this paper as [16]
In the citing paper
“These data are consistent with those of other viral-challenge studies that found a positive association between proinflammatory cytokine levels and symptom expression (16).”
From Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk (2012) · cites this paper as [16]
Citations
Cites
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
Self-citationDiagnostic Procedures for Viral, Rickettsial and Chlamydial Infections
Lennette, E. H., Lennette, D. A., & Lennette, E. T. (1989) · Virtual Defense Library (Ministerio de Defensa) · Cited by 2,353
Psychological Stress and Susceptibility to the Common Cold
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108293250903 · Cited by 1,712
Self-citationStress and infectious disease in humans.
Cohen, S., & Williamson, G. M. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.109.1.5 · Cited by 756
Self-citationHayden, F. G., Fritz, R., Lobo, M. C., Alvord, W. G., Strober, W., & Straus, S. E. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1355 · Cited by 680
Negative life events, perceived stress, negative affect, and susceptibility to the common cold.
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1993) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.64.1.131 · Cited by 623
Self-citationZhou, D., Kusnecov, A. W., Shurin, M. R., DePaoli, M., & Rabin, B. S. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243274 · Cited by 494
Tobita, K., Sugiura, A., Enomoto, C., & Furuyama, M. (1975) · Medical Microbiology and Immunology · doi:10.1007/bf02123572 · Cited by 407
Types of stressors that increase susceptibility to the common cold in healthy adults.
Cohen, S., Frank, E., Doyle, W. J., Skoner, D. P., Rabin, B. S., & Gwaltney, J. M. (1998) · Health Psychology · doi:10.1037/0278-6133.17.3.214 · Cited by 388
Self-citation
Research works printed but not linked: 1
- Clover, 1989, J Fam Pract, 28, 536
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Hassoulas, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821573-9.00006-0 · Cited by 4
Heiderscheit, A. L. (2005) · University of Minnesota Digital Conservancy (University of Minnesota) · Cited by 1
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Kim, B. J. (2010) · Digital Commons @ UNT Health Science Center
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Goldman, S. E. (2006) · D-Scholarship@Pitt (University of Pittsburgh)
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Brambilla, F. (2003) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4615-0323-1_13
Web-based studies of lifestyle factors and immune function
Fondell, E. (2011) · Figshare
Yanowitz, T. D. (2009) · D-Scholarship@Pitt (University of Pittsburgh)
Stein, D. J., Luria, O., Tarrasch, R., Goldstein, L., Raviv, G., Weizman, A., & Schwarz, Y. (2006) · Quality of Life Research · doi:10.1007/s11136-005-5477-9
Weinberg, J. R. (2022) · Digital Archive @ GSU · doi:10.57709/2194574
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Farley, C. J. (2010) · Anglia Ruskin Research Online (Anglia Ruskin University)
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Dunbar, L. (2008) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3dz08n9
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Knox, A. M. (2013) · UC Research Repository (University of Canterbury) · doi:10.26021/6622
Lovell, B. (2014) · Northumbria Research Link (Northumbria University)
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Luensmann, A. M. (2004) · UNI ScholarWorks (University of Northern Iowa)
Lovejoy, T. I. (2013) · Springer eBooks · doi:10.1007/978-1-4419-1005-9_631
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Ola, O. (2019) · D-Scholarship@Pitt (University of Pittsburgh)
Ogollah, R. O. (2010) · Bournemouth University Research Online (Bournemouth University)
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Cimoch, P. J., Allen-Evenson, S., Place, J., Grotto, D., & Silverman, E. (2006) · CRC Press eBooks · doi:10.1201/9781420003413.ch15
Common Cold: The Stress Factor
Janicki‐Deverts, D., & Crittenden, C. N. (2020) · Springer eBooks · doi:10.1007/978-3-030-39903-0_796
Common Cold: The Stress Factor
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The Income-Associated Burden of Disease in the United States
(2012) · SpringerReference · doi:10.1007/springerreference_73356
(2011) · Elsevier eBooks · doi:10.1016/b978-0-7295-3804-6.50015-5
(2016) · Elsevier eBooks · doi:10.1016/b978-3-437-21833-0.16001-2
Stress levels in patients visiting for dental treatment: a cross-sectional hospital-based study
Nayyar, A., Suresh, B., Chandolu, S., Deivanayagi, M., Ramana, R. V., Navaneet, S., & Ramesh, N. (2022) · Menoufia Medical Journal · doi:10.4103/mmj.mmj_212_21
Miller, G. E., Stetler, C., Murali, R., & Chen, E. (2004) · CRC Press eBooks · doi:10.1201/9781420039702.ch7
Suh, H., Moon, E., Park, S., Lee, B. D., Lee, Y. M., Kim, K., & Lee, H. (2024) · Mood and Emotion · doi:10.35986/me.2024.22.2.37
10 Viral RhinitisViral rhinitis
(2025) · Thieme Medical Publishers eBooks · doi:10.1055/b-0045-211965
Jancetic, T. R., Lembo, M., Hampson, C. L., Smith, D. D., Peraza, J. A., Thompson, E., Sánchez, M., González, R., Meca, A., & Laird, A. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.24.671805
Stress modifies pulmonary and inflammatory response to ozone: controlled human exposure study
Pulczinski, J. C., Kahle, J. J., Case, M., Rappold, A. G., Díaz-Sánchez, D., & Dhingra, R. (2025) · Environmental Research · doi:10.1016/j.envres.2025.122924
Stress, Influenza, and Health Behavior: Implications for Pandemic Influenza and Infection Control.
Pérez, V. (2010) · Deep Blue (University of Michigan)
Zanella, G. C., Cárdenas, M., Hutter, C. R., Snyder, C. A., Brand, M. W., Arruda, B. L., Perez, D. R., Anderson, T. K., Rajão, D. S., & Baker, A. L. V. (2026) · Journal of Virology · doi:10.1128/jvi.01975-25
L’expérience doctorale : stress, santé, relation d’encadrement
Haag, P. (2018) · theses.fr (ABES) · doi:10.70675/b74e2e85zf636z4df6z9b0ez538c5f963876
Song, S. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101358
Park, J. W., Lee, S. M., Kim, H. J., Kwon, J. M., Kim, H. M., Jeong, S. H., Moon, Y. G., Hwan, K. H., & Oh, T. W. (2026) · Applied Biological Chemistry · doi:10.1186/s13765-026-01139-5
Marrie, R. A., Kowalec, K., Fakolade, A. O., Fisk, J., Donkers, S. J., Maxwell, C. J., Smyth, P. S., Wolfson, C. M., & Finlayson, M. L. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107983
Stress, Allostatic Load, and Health of Mexican Immigrants*
Kaestner, R., Pearson, J. A., Keene, D., & Geronimus, A. T. (2009) · Social Science Quarterly · doi:10.1111/j.1540-6237.2009.00648.x · Cited by 171
Metadata
- Authors
- Cohen, S., Doyle, W. J., & Skoner, D. P.
- Affiliations
- Carnegie Mellon University (US)
- University of Pittsburgh (US)
- Venue
- Psychosomatic Medicine
- Published
- 1999
- Volume
- 61
- Issue
- 2
- Pages
- 175-180
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2055500474
- Semantic Scholar
- 2d98f8254ce30bd4fed98401edd452b8dc503eb5
- Cited by
- 356
- References
- 30
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 15 · 2020: 14 · 2019: 8 · 2018: 15 · 2017: 14 · 2016: 13 · 2015: 9 · 2014: 16 · 2013: 14 · 2012: 20
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- KiltHub Repository (submittedVersion)
- KiltHub Repository
- Funders
- National Institutes of Health (5r01mh050429-08, 5r01dc002833-02)
- National Institute of Mental Health (MH-50429, MH00721)
- National Institute on Deafness and Other Communication Disorders (DC02833)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- psychological stress, cytokine production, interleukin-6, upper respiratory tract infection, influenza A virus, disease severity, nasal irrigation, mucus production, inflammatory cytokines, tissue damage
- MeSH terms
- Haemophilus Infections, Humans, Quarantine, Respiratory Tract Infections, Severity of Illness Index, Stress, Psychological, Cohort Studies, Cytokines, Nasal Lavage Fluid
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