The DOI matches its Crossref record; 27 of the 30 references it cites were found in a registry or an index.
Psychological Stress, Cytokine Production, and Severity of Upper Respiratory Illness
Open accessAbstract
OBJECTIVE: The purpose of this study is to assess the role of psychological stress in the expression of illness among infected subjects and to test the plausibility of local proinflammatory cytokine production as a pathway linking stress to illness. METHODS: After completing a measure of psychological stress, 55 subjects were experimentally infected with an influenza A virus. Subjects were monitored in quarantine daily for upper respiratory symptoms, mucus production, and nasal lavage levels of interleukin (IL)-6. RESULTS: Higher psychological stress assessed before the viral challenge was associated with greater symptom scores, greater mucus weights, and higher IL-6 lavage concentrations in response to infection. The IL-6 response was temporally related to the two markers of illness severity, and mediation analyses indicated that these data were consistent with IL-6 acting as a major pathway through which stress was associated with increased symptoms of illness. However, this pattern of data is also consistent with increases in IL-6 occurring in response to tissue damage associated with illness symptoms. CONCLUSIONS: Psychological stress predicts a greater expression of illness and an increased production of IL-6 in response to an upper respiratory infection.
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In the citing paper
“A series of studies have shown that chronic stress is associated with increased susceptibility to developing a common cold among persons experimentally exposed to an upper respiratory virus (e.g., refs.[14][15][16][17].”
From Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk (2012) · cites this paper as [16]
In the citing paper
“there is evidence consistent with stress effects resulting in increased disease risk because of their association with exaggerated local (in the nose) release of inflammatory cytokines (16).”
From Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk (2012) · cites this paper as [16]
In the citing paper
“These data are consistent with those of other viral-challenge studies that found a positive association between proinflammatory cytokine levels and symptom expression (16).”
From Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk (2012) · cites this paper as [16]
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Self-citation
Metadata
- Authors
- Cohen, S., Doyle, W. J., & Skoner, D. P.
- Affiliations
- Carnegie Mellon University (US)
- University of Pittsburgh (US)
- Venue
- Psychosomatic Medicine
- Published
- 1999
- Volume
- 61
- Issue
- 2
- Pages
- 175-180
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2055500474
- Semantic Scholar
- 2d98f8254ce30bd4fed98401edd452b8dc503eb5
- Cited by
- 356
- References
- 30
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 15 · 2020: 14 · 2019: 8 · 2018: 15 · 2017: 14 · 2016: 13 · 2015: 9 · 2014: 16 · 2013: 14 · 2012: 20
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- KiltHub Repository (submittedVersion)
- KiltHub Repository
- Funders
- National Institutes of Health (5r01mh050429-08, 5r01dc002833-02)
- National Institute of Mental Health (MH-50429, MH00721)
- National Institute on Deafness and Other Communication Disorders (DC02833)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- psychological stress, cytokine production, interleukin-6, upper respiratory tract infection, influenza A virus, disease severity, nasal irrigation, mucus production, inflammatory cytokines, tissue damage
- MeSH terms
- Haemophilus Infections, Humans, Quarantine, Respiratory Tract Infections, Severity of Illness Index, Stress, Psychological, Cohort Studies, Cytokines, Nasal Lavage Fluid
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