The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Chronic Stress Modulates the Immune Response to a Pneumococcal Pneumonia Vaccine
Abstract
OBJECTIVE: Influenza and pneumonia account for significant morbidity and mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control subjects. This study tested the hypothesis that stress can also significantly inhibit the IgG antibody response to a pneumococcal bacterial vaccine. METHOD: We measured antibody titers of current caregivers, former caregivers, and control subjects after vaccination with a pneumococcal bacterial vaccine. RESULTS: Caregivers showed deficits relative to controls and former caregivers in their antibody responses to vaccination. Although the groups did not differ before vaccination or in the rise in antibody 2 weeks or 1 month after vaccination, current caregivers had lower antibody titers 3 and 6 months after vaccination than either former caregivers or controls. CONCLUSIONS: These data, the first evidence that chronic stress can inhibit the stability of the IgG antibody response to a bacterial vaccine for pneumonia, provide additional evidence of health risks associated with dementia caregiving.
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“A growing body of evidence has implicated caregiving as a risk factor for health.”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“they have poorer immune responses to influenza virus and pneumococcal pneumonia vaccines (2-4)”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“negative emotions contribute to greater risk for infection, prolonged infection, and delayed wound healing (1-5)”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“caregivers report more infectious illness episodes, and they have poorer immune responses to influenza virus and pneumococcal pneumonia vaccines than noncaregivers (1-4).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
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Metadata
- Authors
- Glaser, R., Sheridan, J., Malarkey, W. B., MacCallum, R. C., & Kiecolt-Glaser, J. K.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Glaser, Ronald
- Venue
- Psychosomatic Medicine
- Published
- 2000-11
- Volume
- 62
- Issue
- 6
- Pages
- 804-807
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2109702099
- Cited by
- 295
- References
- 17
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 10 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 18 · 2014: 22 · 2013: 13 · 2012: 20
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh050538-05, 5k02mh001467-05, 5r37mh042096-15)
- National Institute of Mental Health (K02 MH01467, R37 MH42096, R01 MH50538)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- chronic stress, pneumococcal vaccine, vaccine antibody response, IgG antibody titers, dementia caregivers, spousal caregiving, vaccine immunogenicity, pneumonia vaccination, older adults
- MeSH terms
- Alzheimer Disease, Antibodies, Bacterial, Female, Humans, Immune Tolerance, Male, Middle Aged, Streptococcus pneumoniae, Stress, Psychological, Caregivers, Pneumococcal Vaccines
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