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Chronic Stress Modulates the Immune Response to a Pneumococcal Pneumonia Vaccine
Abstract
OBJECTIVE: Influenza and pneumonia account for significant morbidity and mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control subjects. This study tested the hypothesis that stress can also significantly inhibit the IgG antibody response to a pneumococcal bacterial vaccine. METHOD: We measured antibody titers of current caregivers, former caregivers, and control subjects after vaccination with a pneumococcal bacterial vaccine. RESULTS: Caregivers showed deficits relative to controls and former caregivers in their antibody responses to vaccination. Although the groups did not differ before vaccination or in the rise in antibody 2 weeks or 1 month after vaccination, current caregivers had lower antibody titers 3 and 6 months after vaccination than either former caregivers or controls. CONCLUSIONS: These data, the first evidence that chronic stress can inhibit the stability of the IgG antibody response to a bacterial vaccine for pneumonia, provide additional evidence of health risks associated with dementia caregiving.
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“A growing body of evidence has implicated caregiving as a risk factor for health.”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“they have poorer immune responses to influenza virus and pneumococcal pneumonia vaccines (2-4)”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“negative emotions contribute to greater risk for infection, prolonged infection, and delayed wound healing (1-5)”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“caregivers report more infectious illness episodes, and they have poorer immune responses to influenza virus and pneumococcal pneumonia vaccines than noncaregivers (1-4).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
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Lord, J. M., Phillips, A. C., & Arlt, W. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_24 · Cited by 5
“These include a reduced response to pneumococcal pneumonia vaccination and poorer in vitro NK-cell cytotoxicity [133, 134 ].”
BackgroundNervous, Endocrine, Immune Systems As a Target for Complementary and Alternative Medicine
Kasahara, S., & Cooper, E. L. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-4820-8_27 · Cited by 5
Are Changes in the Immune System Predictive of Clinical Diseases?
Luster, M. I., Germolec, D. R., Parks, C. G., Blanciforti, L., Kashon, M. L., & Luebke, R. W. (2005) · Informa Healthcare eBooks · doi:10.1201/9781420036817.sec3 · Cited by 5
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Bonneau, R. H., & Hunzeker, J. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50058-7 · Cited by 5
Psychoneuroimmunology. The relationship between stress, immune system and health
Schulz, K., & Gold, S. M. (2006) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · Cited by 5
Conditioning of Immune Reactions
Gorczynski, L. Y., & Gorczynski, R. M. (2010) · Neuroimmune biology · doi:10.1016/s1567-7443(10)70017-x · Cited by 5
Anticytomegalovirus antibody titres are not associated with caregiving burden in younger caregivers
Vitlić, A., Phillips, A. C., Gallagher, S. M., Oliver, C., Lord, J. M., & Moss, P. A. H. (2014) · British Journal of Health Psychology · doi:10.1111/bjhp.12092 · Cited by 4
Méndez, S. B., Matus-Ortega, M., Hernández-Miramontes, R., & Salazar‐Juárez, A. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114345 · Cited by 4
The Effects of Psychological Stressors on the Intestinal Microbiota
Bailey, M. T. (2009) · Bioscience and Microflora · doi:10.12938/bifidus.28.125 · Cited by 3
Measuring Vaccine Responses in the Multiplex Era
Ayling, K., Vedhara, K., & Fairclough, L. C. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7828-1_17 · Cited by 4
Luster, M. I., Germolec, D. R., Parks, C. G., Blaciforti, L., Kashon, M. L., & Luebke, R. W. (2004) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx1801s20 · Cited by 4
“As shown in Figure 18 .1.3, even more striking were the effects on pneumococcal vaccine responses in caregivers, where a significant decrease in antibody titer occurred in current caregivers compared to controls over the 6-month period following immunization-F(5.82,142.46) = 2.56; p < 0.03; Glaser et al., 2000 .”
BackgroundInfluentialOnyango, R. O. (2009) · PubMed · Cited by 4
Stress-associated Immune Dysregulation Can Affect Antibody and T-cell Responses to Vaccines
Wetherell, M. A., & Vedhara, K. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50049-6 · Cited by 4
van Tilburg, M. A. L. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-709-9_6 · Cited by 4
Support groups for caregivers of patients with Dementia: A comparative study
Foss, M. P., Lange, C., Filho, J. H. S., Brunini, F., & Vale, F. A. C. (2007) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642008dn10200013 · Cited by 4
“Kiecolt-Glaser et al.5,8 and Glaser et al.6,7 have provided evidence of the mechanisms by which chronic stressors (caregiving for a spouse with progressive dementia) may accelerate the risk of a host of age-related diseases by prematurely aging the immune response.”
BackgroundUsing Vaccinations to Assess In Vivo Immune Function in Psychoneuroimmunology
Burns, V. E. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-071-7_19 · Cited by 4
Stress, Coping, and Immune Function
Dougall, A. L., Biglan, M. C. W., Swanson, J. N., & Baum, A. E. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop203016 · Cited by 4
Klein, L. C., Corwin, E. J., & Ceballos, R. M. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841262.011 · Cited by 3
Interactions Between Caregiving and Sex and the Antibody Response to COVID-19 Vaccination
Gallagher, S. M., Ryan, R., Cassidy, I., Tang, W., & Phillips, A. C. (2024) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001322 · Cited by 3
“For example, a lower response to a thymus-independent bacterial vaccine (e.g., pneumococcal) was found in older spousal caregivers of dementia patients relative to controls (11).”
Anthrax Vaccination, Gulf War Illness, and Human Leukocyte Antigen (HLA)
James, L. M., Carpenter, A. F., Engdahl, B. E., Johnson, R., Lewis, S. M., & Georgopoulos, A. P. (2024) · Vaccines · doi:10.3390/vaccines12060613 · Cited by 3
“A key contribution of the present study is the discovery of a subset of HLA Class II alleles which (a) are involved in the production of antibodies, (b) are present in vaccinated healthy veterans but (c) are absent in vaccinated veterans suffering from GWI.”
BackgroundVAKSINASI LANSIA UPAYA PREVENTIF MENINGKATKAN IMUNITAS AKIBAT PROSES PENUAAN
Susanti, N. (2014) · El-Hayah Jurnal Biologi · doi:10.18860/elha.v4i2.2629 · Cited by 3
Effects of a chronic stress treatment on vaccinal response in lambs
Destrez, A., Boissy, A., Guilloteau, L. L. A., Andanson, S., Souriau, A., Laroucau, K., Chaillou, É., & Deiss, V. (2016) · animal · doi:10.1017/s1751731116002317 · Cited by 3
Exercise and psychoneuroimmunology
Kohut, M. L. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.06.002 · Cited by 4
Metadata
- Authors
- Glaser, R., Sheridan, J., Malarkey, W. B., MacCallum, R. C., & Kiecolt-Glaser, J. K.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Glaser, Ronald
- Venue
- Psychosomatic Medicine
- Published
- 2000-11
- Volume
- 62
- Issue
- 6
- Pages
- 804-807
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2109702099
- Cited by
- 295
- References
- 17
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 10 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 18 · 2014: 22 · 2013: 13 · 2012: 20
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh050538-05, 5k02mh001467-05, 5r37mh042096-15)
- National Institute of Mental Health (K02 MH01467, R37 MH42096, R01 MH50538)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- chronic stress, pneumococcal vaccine, vaccine antibody response, IgG antibody titers, dementia caregivers, spousal caregiving, vaccine immunogenicity, pneumonia vaccination, older adults
- MeSH terms
- Alzheimer Disease, Antibodies, Bacterial, Female, Humans, Immune Tolerance, Male, Middle Aged, Streptococcus pneumoniae, Stress, Psychological, Caregivers, Pneumococcal Vaccines
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