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Intestinal flora and endogenous vitamin synthesis
Abstract
It is well established that the rumen microbial flora are a rich source of vitamins to the ruminant, and that the faecal bacterial flora are a major vitamin source for coprophagic rodents. There is also good evidence that the gut bacterial flora are a significant source of a range of vitamins to the human. In this paper evidence is presented that gut bacteria are a significant source of a range of vitamins, particularly those of the B group and vitamin K.
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“It is well appreciated that the gut microbiota can synthesize certain vitamins, most notably vitamin K and B-group vitamins [e.g., cobalamin (B 12 ), folate, and riboflavin (144, 145)], some of which might be directly absorbed.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [144]
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Sales, K. M., & Reimer, R. A. (2022) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.09.002 · Cited by 106
Ofoedu, C. E., Iwouno, J. O., Ofoedu, E. O., Ogueke, C. C., Igwe, V. S., Agunwah, I. M., Ofoedum, A. F., Chacha, J. S., Muobike, O. P., Agunbiade, A. O., et al. (2021) · PeerJ · doi:10.7717/peerj.11940 · Cited by 109
“Hill MJ. 1997.”
Host control and the evolution of cooperation in host microbiomes
Sharp, C., & Foster, K. R. (2022) · Nature Communications · doi:10.1038/s41467-022-30971-8 · Cited by 93
Metabolic functions of the human gut microbiota: the role of metalloenzymes
Rajakovich, L. J., & Balskus, E. P. (2018) · Natural Product Reports · doi:10.1039/c8np00074c · Cited by 91
Hati, S., Patel, M., Mishra, B. K., & Das, S. (2019) · Annals of Microbiology · doi:10.1007/s13213-019-01500-8 · Cited by 93
Kellow, N. J., Coughlan, M. T., Savige, G. S., & Reid, C. M. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-55 · Cited by 93
“Gut bacteria play an important role in the host immune system, modulation of inflammatory processes, extraction of energy from the host’s diet, fermentation of dietary fibres to produce short-chain fatty acids, alteration of human gene expression, regulation of intestinal permeability, production of some vitamins and…”
BackgroundStubbendieck, R. M., May, D. S., Chevrette, M. G., Temkin, M. I., Wendt-Pienkowski, E., Cagnazzo, J., Carlson, C. M., Gern, J. E., & Currie, C. R. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02406-18 · Cited by 86
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BackgroundSantacroce, L., Man, A., Charitos, I. A., Haxhirexha, K., & Topi, S. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4930 · Cited by 90
Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology
Engevik, M. A., & Versalovic, J. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0012-2016 · Cited by 87
Impact of dietary gut microbial metabolites on the epigenome
Gerhäuser, C. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0359 · Cited by 85
Gut microbiota, kynurenine pathway and mental disorders – Review
Więdłocha, M., Marcinowicz, P., Janoska-Jaździk, M., & Szulc, A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110145 · Cited by 90
Obesity and Asthma: Microbiome–Metabolome Interactions
Shore, S. A., & Cho, Y. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0052ps · Cited by 86
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Honneffer, J. B., Steiner, J. M., Lidbury, J. A., & Suchodolski, J. S. (2017) · Metabolomics · doi:10.1007/s11306-017-1165-3 · Cited by 100
“2012); vitamin K, cobalamin, folate, biotin, and thiamine (Hill 1997; LeBlanc et al.”
BackgroundThe Gut Microbiota and their Metabolites: Potential Implications for the Host Epigenome
Mischke, M., & Plösch, T. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-31248-4_3 · Cited by 86
Abnous, K., Brooks, S. P. J., Kwan, J., Matias, F. M. G., Green-Johnson, J. M., Selinger, L. B., Thomas, M. C., & Kalmokoff, M. L. (2009) · Journal of Nutrition · doi:10.3945/jn.109.109470 · Cited by 83
Health-Improving Effects of Polyphenols on the Human Intestinal Microbiota: A Review
Nemzer, B. V., Al-Taher, F., Kalita, D., Yashin, A. Y., & Yashin, Y. I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031335 · Cited by 93
Clinical Evidence for Immunomodulatory Effects of Probiotic Bacteria
Ruemmele, F. M., Bier, D. M., Marteau, P. R., Rechkemmer, G., Bourdet‐Sicard, R., Walker, W., & Goulet, O. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31817d80ca · Cited by 82
“Another example of beneficial symbiosis is the regulation of the production of different vitamins, particularly vitamins B and K, by intestinal microbiota (16).”
BackgroundLampe, J. W. (2011) · Journal of the American College of Nutrition · doi:10.1080/07315724.2011.10719991 · Cited by 79
“For example, rumen bacteria isomerize linoleic acid to conjugated linoleic acid (CLA) [15], convert isoflavones from clover and other legumes to various metabolites [16], and produce other nutrients such as vitamin K and the B vitamins [17].”
BackgroundThe gut–kidney–heart axis in chronic kidney disease
Sumida, K., & Kovesdy, C. P. (2019) · Physiology International · doi:10.1556/2060.106.2019.19 · Cited by 80
“These complementary metabolic activities include synthesis of certain vitamins (30), degradation of undigestible plant polysaccharides and oxalates (32), and biotransformation of conjugated bile acids (34).”
BackgroundGut microflora & toxic metals: chromium as a model.
Upreti, R. K., Shrivastava, R., & Chaturvedi, U. C. (2004) · PubMed · Cited by 76
RetractedThe potential role of B5: A stitch in time and switch in cytokine
Gheita, A., Gheita, T. A., & Kenawy, S. A. (2019) · Phytotherapy Research · doi:10.1002/ptr.6537 · Cited by 76
“Probiotic bacteria, members of the gut microbiota, are able to synthesize panthotenic acid in humans (Hill, 1997).”
BackgroundThe potential for probiotic manipulation of the gastrointestinal microbiome
Rauch, M., & Lynch, S. V. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.11.004 · Cited by 80
Immunotoxic effects of lead on birds
Vallverdú‐Coll, N., Mateo, R., Mougeot, F., et al. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.06.251 · Cited by 76
Microbiota in Gut‐Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease
Kondapalli, N. B., Katari, V., Dalal, K. K., Paruchuri, S. M., & Thodeti, C. K. (2025) · Comprehensive physiology · doi:10.1002/cph4.70024 · Cited by 98
“…vitamin K, and B group vitamins including biotin, cobalamin, folates, nicotinic acid, pantothenic acid, pyridoxine, riboflavin, and thiamine (Hill 1997) and plays some pivotal functions in the development and modulation of the immune system, training immune cells to distinguish be-tween…”
Human gut microbiota plays a role in the metabolism of drugs
Jourová, L., Anzenbacher, P., & Anzenbacherová, E. (2016) · Biomedical Papers · doi:10.5507/bp.2016.039 · Cited by 77
Heinsen, F., Fangmann, D., Müller, N., Schulte, D. M., Rühlemann, M. C., Türk, K., Settgast, U., Lieb, W., Baines, J. F., Schreiber, S., et al. (2016) · Obesity Facts · doi:10.1159/000449506 · Cited by 76
Biosynthesis of Vitamins by Probiotic Bacteria
Gu, Q., & Li, P. (2016) · InTech eBooks · doi:10.5772/63117 · Cited by 79
“Probiotic bacteria, members of the gut microbiota, are able to synthesize vitamin K and most of the water‐ soluble B vitamins, such as biotin, cobalamin, folates, nicotinic acid, panthotenic acid, pyri‐ doxine, riboflavin, and thiamine, in humans [6].”
BackgroundGarcía-Peris, P., Velasco, C., Lozano, M. A., Moreno, Y., Paron, L., Cuerda, C., Lesmes, I. B., Camblor, M., García‐Hernández, J., Guarner, F., et al. (2012) · PubMed · doi:10.3305/nh.2012.27.6.5992 · Cited by 73
Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?
Portincasa, P., Khalil, M., Graziani, A., Frühbeck, G., Baffy, G., Garruti, G., Ciaula, A. D., & Bonfrate, L. (2023) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2023.10.002 · Cited by 78
Xie, G., Zhang, S., Zheng, X., & Jia, W. P. (2013) · Electrophoresis · doi:10.1002/elps.201300017 · Cited by 71
Dietary Influences on the Microbiota–Gut–Brain Axis
Barber, T. M., Valsamakis, G., Mastorakos, G. P., Hanson, P., Kyrou, I., Randeva, H. S., & Weickert, M. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073502 · Cited by 78
Composition and function of the human-associated microbiota
Bik, E. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00237.x · Cited by 73
Noce, A., Tarantino, A., Claudette, T. D., Vasili, E., LORENZO, A. D., & Nicola, D. D. (2014) · Mediators of Inflammation · doi:10.1155/2014/901308 · Cited by 73
“[62] as well as those acting as vitamins [63] or energy sources [64].”
Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges
Ailioaie, L. M., & Litscher, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094942 · Cited by 70
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Łuc, M., Misiak, B., Pawłowski, M., Stańczykiewicz, B., Zabłocka, A., Szcześniak, D. M., Pałęga, A., & Rymaszewska, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110039 · Cited by 69
“Gut microbiota is known to produce neurotransmitters, such as GABA, acetylcholine, dopamine or serotonin, vitamins, intestinal toxins, and modulate nerve signaling – with emphasis on vagus nerve (Barrett et al., 2012; Bravo et al., 2011; Brenner, 2013; Fox et al., 2019; Hill, 1997; O’Mahony et al., 2015; Yunes et al.,…”
BackgroundThe Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders
Islam, M. R., Arthur, S., Haynes, J., Butts, M. R., Nepal, N., & Sundaram, U. (2022) · Nutrients · doi:10.3390/nu14030624 · Cited by 73
The small intestine: dining table of host–microbiota meetings
Delbaere, K., Roegiers, I. H., Bron, A., Durif, C., de Wiele, T. V., Blanquet‐Diot, S., & Marinelli, L. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad022 · Cited by 73
Liwinski, T., & Lang, U. E. (2023) · Nutrients · doi:10.3390/nu15173859 · Cited by 77
“Through these processes, the gut microbiota contributes to the overall nutrient balance and energy metabolism of the host [150,151].”
BackgroundMicrobiome to Brain: Unravelling the Multidirectional Axes of Communication
Aidy, S. E., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-20215-0_15 · Cited by 65
“VITAMINS B12 and K are synthesized by the intestinal microbiota that are also capable of producing most of the water-soluble B vitamins, such as biotin, cobala-min, folates, nicotinic acid, panthotenic acid, pyridoxine, ribofl avin and thiamine in humans (Hill 1997 ).”
BackgroundGlenny, E. M., Bulik‐Sullivan, E. C., Tang, Q., Bulik, C. M., & Carroll, I. M. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0797-3 · Cited by 71
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Hu, C., Liu, M., Tang, L., Liu, H., Sun, B., & Chen, L. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.131374 · Cited by 58
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Intili, G., Paladino, L., Rappa, F., Alberti, G., Plicato, A., Calabrò, F., Fucarino, A., Cappello, F., Bucchieri, F., Tomasello, G., et al. (2023) · Biology · doi:10.3390/biology12020195 · Cited by 66
“In particular, the maintenance of the tissue homeostasis is mediated by the production of the extracellular vesicles (EVs), secreted by all cell types, contributing significantly to coordinated signaling events and crosstalk between the microbiota, the IECs, the endothelial cells, and the immune cells [73].”
BackgroundInfluentialSpecific metabolite production by gut microbiota as a basis for probiotic function
Ross, R. P., Mills, S., Hill, C., Fitzgerald, G. F., & Stanton, C. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.12.003 · Cited by 61
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“41,86–88), although the consumption of animal products is likely to be the main source for this nutrient.”
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Tan, K., Tesar, C., Wilton, R., Keigher, L., Babnigg, G., & Joachimiak, A. (2010) · The FASEB Journal · doi:10.1096/fj.10-156257 · Cited by 59
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“The gut microbiota is also producing essential vitamins [30], including B vitamins (e.g. B12, folate, riboflavin) and vitamin K, which are important for various physiological functions [31,32].”
Li, L., & Somerset, S. M. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.004 · Cited by 59
“[86].”
Role of Intestinal Microbiome in Lipid and Glucose Metabolism in Diabetes Mellitus
van Olden, C. C., Groen, A. K., & Nieuwdorp, M. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.008 · Cited by 61
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Yeoman, C. J., Chia, N., Yıldırım, S., Miller, M. E. B., Kent, A. D., Stumpf, R. M., Leigh, S. R., Nelson, K. E., White, B. A., & Wilson, B. A. (2011) · Entropy · doi:10.3390/e13030570 · Cited by 59
“The mammalian GI microbiome has been shown to make additional contributions to host health by producing vitamins [20],”
BackgroundWong, C. B., Sugahara, H., Odamaki, T., & Xiao, J. (2017) · Beneficial Microbes · doi:10.3920/bm2017.0031 · Cited by 56
Partrick, K. A., Rosenhauer, A. M., Auger, J., Arnold, A. R., Ronczkowski, N. M., Jackson, L. M., Lord, M. N., Abdulla, S. M., Chassaing, B., & Huhman, K. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-83284-z · Cited by 56
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“, vitamin K6 and vitamin B group) [12], degradation of undigestible plant polysaccharides and oxalates [13], and biotransformation of conjugated bile acids [14].”
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Khan, I. M., Nassar, N., Chang, H., Khan, S., Cheng, M., Wang, Z., & Xiang, X. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1480811 · Cited by 61
Rubini, E., Schenkelaars, N., Rousian, M., Sinclair, K. D., Wekema, L., Faas, M. M., Steegers‐Theunissen, R. P. M., & Schoenmakers, S. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.04.013 · Cited by 58
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BackgroundTottey, W., Denonfoux, J., Jaziri, F., Parisot, N., Missaoui, M., Hill, D. R. C., Borrel, G., Peyretaillade, É., Alric, M., Harris, H. M. B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062544 · Cited by 53
Microbiota–host interactions shape ageing dynamics
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“Essential vitamins, such as cobalamin (vitamin B12), folic acid (vitamin B9), biotin, as well as secondary bile acids, are key products of microbiota metabolism [62].”
BackgroundMetabolomics: Towards Understanding Host–Microbe Interactions
Han, J., Antunes, L. C. M., Finlay, B. B., & Borchers, C. H. (2010) · Future Microbiology · doi:10.2217/fmb.09.132 · Cited by 51
“For instance, the gut microbiota has been implicated in the synthesis of some essential vitamins, especially the B group and vitamin K [32].”
BackgroundChen, L., Hsiao, F., Shen, L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158407 · Cited by 51
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Amini, M. E., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107024 · Cited by 54
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Rosado, D., Pérez‐Losada, M., Pereira, A., Severino, R., & Xavier, R. (2021) · Animal Microbiome · doi:10.1186/s42523-020-00072-2 · Cited by 50
Merrifield, C. A., Lewis, M. C., Berger, B. W., Cloarec, O., Heinzmann, S. S., Charton, F., Krause, L., Levin, N. S., Duncker, S. C., Mercenier, A., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2015.90 · Cited by 50
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BackgroundGorlé, N., Bauwens, E., Haesebrouck, F., Smet, A., & Vandenbroucke, R. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584165 · Cited by 49
“These commensal microbes perform several functions essential to our health and survival, including food digestion (5, 6), activation of certain drugs (4), prevention of infections (7–9), and they might play a role in the maturation of our immune system (10, 11).”
BackgroundBeneficial insights into postbiotics against colorectal cancer
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Daliri, E. B., Tango, C. N., Lee, B. H., & Oh, D. (2018) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2018.05.002 · Cited by 50
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Jansen, V. L. B. I., Gerdes, V. E. A., Middeldorp, S., & van Mens, T. E. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101492 · Cited by 50
Sun, H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.010 · Cited by 47
“Human intestinal microbes can produce vitamin K to alleviate its deficiency [4].”
B‐Group Vitamins Production by Probiotic Lactic Acid Bacteria
LeBlanc, J. G., Laiño, J., del Valle, M. J., de Giori, G. S., Sesma, F. J. M., & Taranto, M. P. (2015) · doi:10.1002/9781118868386.ch17 · Cited by 46
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“In addition, gut bacteria take part in the synthesis of vitamin K, biotin, folate, nicotinic acid, pantothenic acid, pyridoxine, riboflavin, and thiamine.(6) Thirdly, the gut microbiota is essential for development and function of the host immune system.”
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Godoy-Parejo, C., Deng, C., Zhang, Y., Liu, W., & Chen, G. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03352-6 · Cited by 45
“Some vitamins can be synthesized in the human body, but at a very low rate (Table 2) [23, 24].”
BackgroundWang, L., Liu, L., Liu, X., Xiang, M., Zhou, L., Huang, C., Shen, Z., & Miao, L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104979 · Cited by 43
Development of Immunocompetence: Role of Micronutrients and Microorganisms
Cunningham–Rundles, S., Ahrn�, S., Abuav-Nussbaum, R., & Dnistrian, A. M. (2002) · Nutrition Reviews · doi:10.1301/00296640260130777 · Cited by 44
Patil, S. V., Sawant, S., Maier-Hauff, K., & Hampp, G. (2018) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9497-5 · Cited by 44
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Shahrbabak, S. S., Khodabandehlou, Z., Shahverdi, A. R., et al. (2013) · Microbiology · doi:10.1099/mic.0.063776-0 · Cited by 41
“The gut microflora has important functions, such as the digestion of remaining carbohydrates, production of K and B group vitamins, ion absorption, intestinal cell differentiation, immune system development and protective effects against pathogens (Guarner & Malagelada, 2003; Hill, 1997; Mazmanian et al., 2005).”
BackgroundOnyszkiewicz, M., Jaworska, K., & Ufnal, M. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219900898 · Cited by 39
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Limdi, J. K. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i34.5447 · Cited by 40
Corriero, A., Giglio, M., Inchingolo, F., Moschetta, A., Varrassi, G., & Puntillo, F. (2023) · Pain and Therapy · doi:10.1007/s40122-023-00565-3 · Cited by 48
Gil‐Solsona, R., Calduch-Giner, J. À., Nácher‐Mestre, J., Lacalle-Bergeron, L., Sancho, J. V., Hernández, F. J., & Pérez‐Sánchez, J. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.08.080 · Cited by 39
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“longum) as the key beneficial species, which interestingly is the only Bifidobacterium species to produce riboflavin [97].”
BackgroundZheng, W., Zhang, Z., Liu, C., Qiao, Y., Zhou, D., Qu, J., An, H., Xiong, M., Zhu, Z., & Zhao, X. (2015) · Scientific Reports · doi:10.1038/srep09131 · Cited by 37
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“In human gut, there are trillions of microbes, which play important roles in human health, including production of vitamins, such as vitamin K and biotin, serotonin, and fermentation of dietary fiber to produce short chain fatty acids and modulation of immunity as well (75-78).”
BackgroundChi, L., Gao, B., Tu, P., Liu, C., Xue, J., Lai, Y., Ru, H., & Lü, K. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9736-9 · Cited by 39
“For example, the gut microbiota has been considered an endogenous source of many vitamins including folate, riboflavin, cobalamin, and vitamin K (Rossi et al. 2011; LeBlanc et al. 2013; Hill 1997).”
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Decoding microbial genomes to understand their functional roles in human complex diseases
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Kurek, M. A., Wyrwisz, J., Karp, S., et al. (2017) · Journal of Cereal Science · doi:10.1016/j.jcs.2017.07.016 · Cited by 35
Sprenger, M., Hartung, T. S., Allert, S., Wisgott, S., Niemiec, M. J., Graf, K., Jacobsen, I. D., Kasper, L., & Hube, B. (2020) · Cellular Microbiology · doi:10.1111/cmi.13197 · Cited by 36
“glabrata live in close proximity to other microbes, which are often able to synthesise biotin and likely provide this vitamin or biosynthesis intermediates to colonising Candida cells (Hill, 1997).”
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“Host-microbial interactions are necessary to ensure host fitness, allowing nutrient uptake, neutralizing toxins, and synthesizing essential biomolecules (Hill, 1997).”
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Lactic Acid Bacteria in Health and Disease
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Metadata
- Authors
- Hill, M. J.
- Affiliations
- Wexham Park Hospital (GB)
- Corresponding author
- Hill, M J
- ORCID
- Hill, M J
- Venue
- European Journal of Cancer Prevention
- Published
- 1997-03
- Volume
- 6
- Pages
- S43-S45
- ISSN
- 0959-8278 (ISSN-L)
- OpenAlex
- W1994684051
- Cited by
- 551
- References
- 0
- Citations by year
- 2026: 8 · 2025: 34 · 2024: 37 · 2023: 43 · 2022: 44 · 2021: 62 · 2020: 41 · 2019: 27 · 2018: 29 · 2017: 26 · 2016: 27 · 2015: 30 · 2014: 27 · 2013: 30 · 2012: 9
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cancer Prevention (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, B vitamins, vitamin K, vitamin sources, ruminant nutrition, coprophagy, human nutrition
- MeSH terms
- Animals, Biotin, Folic Acid, Humans, Intestines, Riboflavin, Vitamin B 12, Vitamin K, Vitamins
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