Cited by 551Gut microbiota and healthFolate and B Vitamins ResearchProbiotics and Fermented Foods

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Intestinal flora and endogenous vitamin synthesis

Hill, M J·1997·European Journal of Cancer Prevention

DOI 10.1097/00008469-199703001-00009

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Abstract

It is well established that the rumen microbial flora are a rich source of vitamins to the ruminant, and that the faecal bacterial flora are a major vitamin source for coprophagic rodents. There is also good evidence that the gut bacterial flora are a significant source of a range of vitamins to the human. In this paper evidence is presented that gut bacteria are a significant source of a range of vitamins, particularly those of the B group and vitamin K.

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“2006), produce essential compounds (Hill 1997), and provide protection against pathogens (Bachère 2003).”
Background
Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome
Herrala, M., Turunen, S., Hanhineva, K., Lehtonen, M., Mikkonen, J. J. W., Seitsalo, H., Lappalainen, R., Tjäderhane, L., Niemelä, R. K., Salo, T. A., et al. (2021) · Metabolites · doi:10.3390/metabo11090595 · Cited by 15
Experimental exposure to trace metals affects plumage bacterial community in the feral pigeon
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“The normal flora, also called the microbiota, lives in symbiosis with its host, fulfilling essential functions for host metabolism, such as cellulose degradation, vitamins synthesis (Hill 1997) and inhibition of pathogens proliferation (Olsson et al.”
Anaerobes as Sources of Bioactive Compounds and Health Promoting Tools
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Exercise and Prebiotics Produce Stress Resistance
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How the gut microbiota helps keep us vitaminized
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What Differentiates Probiotic from Pathogenic Bacteria? The Genetic Mobility of Enterococcus faecium Offers New Molecular Insights
Santos, D. D. S., Calaça, P. R. D. A., Porto, A. L. F., de Souza, P. R. E., de Freitas, N. S. A., & Cavalcanti, M. T. H. (2020) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2020.0078 · Cited by 15
“Probiotic bacteria, members of the gut microbiota, can synthesize vitamin K and most of the water soluble B vitamins in humans (Hill, 1997).”
ISN Forefronts Symposium 2015: IgA Nephropathy, the Gut Microbiota, and Gut−Kidney Crosstalk
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Characteristics of faecal bacterial flora and volatile fatty acids in Min pig, Landrace pig, and Yorkshire pig
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Development of gut microbiota in the pig : modulation of bacterial communities by different feeding strategies
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Unveiling the mechanistic nexus: how micronutrient enrichment shapes brain function, and cognitive health
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“Gut bacteria produce numerous vitamins, including vitamin K and B vitamins such as folate, riboflavin, and cobalamin (B12) (Hill, 1997; Rowland et al., 2018).”
The Effect of Gut Microbe Dysbiosis on the Pathogenesis of Alzheimer's Disease (AD) and Related Conditions
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Regulation of Gut Microbiota by Herbal Medicines
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Diet Alters Micronutrient Pathways in the Gut and Placenta that Regulate Fetal Growth and Development in Pregnant Mice
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Reduced nerve growth factor levels in stress-related brain regions of folate-deficient mice
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Achieving High Yield of Lactic Acid for Antimicrobial Characterization in Cephalosporin-Resistant Lactobacillus by the Co-Expression of the Phosphofructokinase and Glucokinase
Gong, Y., Li, T., Li, S., Jiang, Z., Yang, Y., Huang, J., Liu, Z., & Sun, H. (2016) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1601.01043 · Cited by 13
Lactobacillus plantarum as a Strategy for an In situ Production of Vitamin B2
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“Human microbiota colonizing the large intestine is also able to produce riboflavin [9].”
Background
Ornithine ingestion improved sleep disturbances but was not associated with correction of blood tryptophan ratio in Japanese Antarctica expedition members during summer
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“[37] Hill MJ.”
Background
Metagenomic profile of the fecal microbiome of preterm infants consuming mother’s own milk with bovine milk–based fortifier or infant formula: a cross-sectional study
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Turtle ants harbor metabolically versatile microbiomes with conserved functions across development and phylogeny
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Effect of Operational Parameters on the Cultivation of the Gut Microbiome in Continuous Bioreactors Inoculated with Feces: A Systematic Review
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“78,79 Magnu ́ sdo ́ ttir et al. (2015) 80 assessed the genomes of 256 common human gut bacteria and identified the presence of biosynthesis pathways for eight B vitamins: biotin, cobalamin, folate, niacin, pantothenate, pyridoxine, riboflavin, and thiamin.”
Background
Role of gut commensal bacteria in juvenile developmental growth of the host: insights from Drosophila studies
Yun, H. M., & Hyun, S. (2023) · Animal Cells and Systems · doi:10.1080/19768354.2023.2282726 · Cited by 14
“It has been hypothesized that the gut microbiota provides the host with various types of vitamin B, such as thiamine, ribo ﬂ a-vin, and folate (Hill 1997; LeBlanc et al. 2013).”
Background
The role of the gut microbiome in neuroinflammation and chemotherapy-induced peripheral neuropathy
Shatunova, S., Aktar, R., Peiris, M., Lee, J. Y. P., Vetter, I., & Starobova, H. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176818 · Cited by 15
Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease
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The Role of Probiotics in Modulating the Gut Microbiome in Alzheimer’s Disease: A Review
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“Bifi-dobacteria promote the synthesis of fat-soluble vitamin K and most water-soluble vitamin B groups [46], including thiamine, riboflavin, pantothenic acids, folic acid, nicotinic acid, biotin, pyridoxine, and cobalamin.”
Cesarean delivery on maternal request and common child health outcomes: A prospective cohort study in China
Si, K., Li, H., Zhou, Y.-B., Li, Z., Zhang, L., Zhang, Y., Ye, R., & Liu, J. (2022) · Journal of Global Health · doi:10.7189/jogh.12.11001 · Cited by 12

Authors: Hill, M. J.
Affiliations: Wexham Park Hospital (GB)
Corresponding author: Hill, M J
ORCID: Hill, M J
Venue: European Journal of Cancer Prevention
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1997-03
Volume: 6
Pages: S43-S45
ISSN: 0959-8278 (ISSN-L)
DOI: 10.1097/00008469-199703001-00009
OpenAlex: W1994684051
Cited by: 551
References: 0
Citations by year: 2026: 8 · 2025: 34 · 2024: 37 · 2023: 43 · 2022: 44 · 2021: 62 · 2020: 41 · 2019: 27 · 2018: 29 · 2017: 26 · 2016: 27 · 2015: 30 · 2014: 27 · 2013: 30 · 2012: 9
FWCI: 0.47
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Cancer Prevention (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, B vitamins, vitamin K, vitamin sources, ruminant nutrition, coprophagy, human nutrition
MeSH terms: Animals, Biotin, Folic Acid, Humans, Intestines, Riboflavin, Vitamin B 12, Vitamin K, Vitamins

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Intestinal flora and endogenous vitamin synthesis

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