The DOI matches its Crossref record.
Impulsivity predicts individual susceptibility to high levels of alcohol self-administration
Abstract
Clinical studies indicate large individual differences in susceptibility to alcohol abuse. Poor behavioral self -regulation has been proposed to reflect a predisposing factor. Like humans, only some rats regularly consume large and intoxicating amounts of alcohol. We hypothesized that clinical indications of impaired behavioral self-regulation should be reflected in an animal model of impulse control, and in this study we assessed impulsivity with a delay-of-reward paradigm. We found that three groups representing three levels of impulsivity predicted augmenting levels of alcohol self-administration. Also, overall impulsivity scores were found to be significantly correlated with magnitude of alcohol self-administration. The finding that high impulsivity is linked to elevated consumption represents an animal model that may mirror clinical depictions of an alcohol abuse syndrome. This animal model may help elucidate the neurobiological basis of individual susceptibility to alcohol addiction.
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In the citing paper
“This finding has been inconsistently replicated, however, with other drugs of abuse”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Poulos et al., 1995
In the citing paper
“In rats, high impulsivity – measured by delay discounting – is a vulnerability factor for both alcohol (Poulos et al., 1995) and cocaine (Perry and Carroll, 2008; Perry et al., 2005) self-administration.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Poulos et al., 1995
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Items 201–234 of 234
Genetic architecture and behavioral analysis of attention and impulsivity
Loos, M. (2012) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) · Cited by 1
Stansfield, K. H. (2007) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1
CENTRO UNIVERSITARIO DE CIENCIAS BIOLÓGICAS Y AGROPECUARIAS
Agronómicas, D. D. C. (2004) · Cited by 1
Jadhav, K. S., Bernheim, A. P., Aeschlimann, L., Kirschmann, G., Décosterd, I., Hoffman, A. F., Lupica, C. R., & Boutrel, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.28.466154 · Cited by 1
Holtz, N. A. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
Behavioral impulsivity and hallucinations : insights from Parkinson's disease
Ashourian, P. (2011) · DSpace@MIT (Massachusetts Institute of Technology)
Stein, J. S. (2010) · KU ScholarWorks (University of Kansas)
CONTRIBUTION OF NUCLEUS ACCUMBENS CORE TO IMPULSIVE CHOICE: ROLE OF DOPAMINE AND GLUTAMATE SYSTEMS
Yates, J. R. (2014) · UKnowledge (University of Kentucky)
Alcohol: Does It Make You Successful? A Longitudinal AnalysisPreprint
Keller, P. (2015) · SSRN Electronic Journal · doi:10.2139/ssrn.2778025
“…of literature in the field of substance abuse links personality traits, such as impatient or impulsive behavior, to a higher vulnerability to substance abuse (Hawkins et al. 1985: 75– 76; Petry 2001: 243–250; Slater et al. 1999: 667–674; Whiteside and Lynam 2003: 210; Poulos et al. 1995: 810-814).”
Impulsive Choice, Alcohol Self-administration, and Pre-exposure to Reward Delay
Stein, J. S. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/2f30-3647
The role of 5-HT1A and 5-HT1B receptors in MDMA self-administration
Aronsen, D. (2016) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17014775
The Roots and Individual Diversity of Addiction
Leis, A. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-420190-3.00031-4
Shram, M. J. (2008) · TSpace (University of Toronto)
Impulsivity and Drug Addiction: A Neurobiological Perspective
Robbins, T. W. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195389715.013.0078
Sex differences in PFC-related behavior after amphetamine exposure and across adolescent development
Hammerslag, L. R. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Tarren, J. R. (2018) · Queensland University of Technology · doi:10.5204/thesis.eprints.118142
Huskinson, S. L. (2011) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.4733
de Laat, B., Klingl, Y. E., Schroyen, G., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-310567/v1
Starski, P. A., Maulucci, D. P., Mead, H., & Hopf, F. W. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.25.493462
Zumbusch, A. S., Samson, A., Chernoff, C. S., Coslovich, B., & Hynes, T. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.28.514235
“For psychostimulants (Belin et al., 2008; Marusich & Bardo, 2009; Perry et al., 2005), alcohol (Poulos et al., 1995), and nicotine (Diergaarde et al., 2009), the association between high impulsivity and addiction-relevant behaviour translates to rodents.”
BackgroundMaladaptive decision making and addiction
Yates, J. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90578-7.00006-2 · Cited by 1
INHIBICIÓN DE RESPUESTAS: SU ESTUDIO Y CONCEPTUALIZACIÓN DESDE DISTINTAS PERSPECTIVAS
Escuela de Pedagogía, U. P., Sosa, R., Ramírez, M. N., & Claustro Docente de Psicología, U. W. (2020) · CONDUCTUAL · doi:10.59792/igoj5852
Animal Models in the Study of Impulsivity
Saland, S. K., Jennings, S. D., Kabbaj, M., & Patrick, C. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-77967-1_9
Starski, P. A., Siegle, A., White, D., Paras, B., Tham, C., Hernández, M., Zareb, A., Grahame, N. J., Boehm, S. L., & Hopf, F. W. (2025) · Genes Brain & Behavior · doi:10.1111/gbb.70026
Similarities and Differences in Diagnostic Criteria
Chen, Y., & Wei, Z. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-2411-2_6
Iwanicka, K., Malicki, D., & Olajossy, M. (2014) · Current Problems of Psychiatry
IMPULSIVITY PROCESSES UNDERLYING DRUG CHOICE AND RISKY SEXUAL BEHAVIOR
Bornovalova, M. A. (2005) · University Libraries (University of Maryland)
DIEMEN, L. V. (2006) · Americanae (AECID Library)
Metadata
- Authors
- Poulos, C. X., Le, A. D., & Parker, J. L.
- Affiliations
- University of Toronto (CA)
- ORCID
- Parker, J. L.
- Venue
- Behavioural Pharmacology
- Published
- 1995-12
- Volume
- 6
- Issue
- 8
- Pages
- 810???814
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W1974743544
- Cited by
- 234
- References
- 0
- Citations by year
- 2025: 6 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 14 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 13 · 2012: 15
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- impulsivity, alcohol self-administration, behavioral self-regulation, reward delay, alcoholism, alcohol abuse
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